Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4

The proinflammatory role of HECTD2 in innate immunity and experimental lung injury

(2015) Tiffany A. Coon et al.   Science Translational Medicine

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

(2015) Nilgun I. Reed et al.   Science Translational Medicine

The Immunology of Fibrosis

(2013) Georg Wick et al.   Annual Review of Immunology

Glycogen synthase kinase-3 (GSK-3) regulates TGF-β1-induced differentiation of pulmonary fibroblasts

(2013) Hoeke A Baarsma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of a Novel Anti-apoptotic E3 Ubiquitin Ligase That Ubiquitinates Antagonists of Inhibitor of Apoptosis Proteins SMAC, HtrA2, and ARTS

(2013) Jung-bin Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROCKing pulmonary fibrosis

(2013) Dean Sheppard   JOURNAL OF CLINICAL INVESTIGATION

Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation

(2013) R. K. Mallampalli et al.   JOURNAL OF IMMUNOLOGY

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation

(2013) Bill B Chen et al.   NATURE IMMUNOLOGY

EMT and interstitial lung disease

(2012) Hidenori Kage et al.   CURRENT OPINION IN PULMONARY MEDICINE

Pulmonary fibrosis: patterns and perpetrators

(2012) Paul W. Noble et al.   JOURNAL OF CLINICAL INVESTIGATION

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis

(2011) Harold A. Chapman   Annual Review of Physiology

Imatinib in active diffuse cutaneous systemic sclerosis: Results of a six-month, randomized, double-blind, placebo-controlled, proof-of-concept pilot study at a single center

(2011) Janet Pope et al.   ARTHRITIS AND RHEUMATISM

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

(2011) Elena Maspero et al.   EMBO REPORTS

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4

(2010) Dianhua Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis

(2010) Min Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia

(2010) Nancy B Ray et al.   NATURE MEDICINE

Imatinib Treatment for Idiopathic Pulmonary Fibrosis

(2009) Craig E. Daniels et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis

(2009) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM

PIAS proteins: pleiotropic interactors associated with SUMO

(2009) Miia M. Rytinki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cross-talk between Remodeling andde NovoPathways Maintains Phospholipid Balance through Ubiquitination

(2009) Phillip L. Butler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex

(2009) Hari B. Kamadurai et al.   MOLECULAR CELL

Pulmonary fibrosis: pathogenesis, etiology and regulation

(2009) M S Wilson et al.   Mucosal Immunology

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-β signaling

(2008) Seiyu Imoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130

(2008) Y. Tanaka et al.   MOLECULAR AND CELLULAR BIOLOGY