Review
Biochemistry & Molecular Biology
Chia-Chun Tseng, Ya-Wen Sung, Kuan-Yu Chen, Pin-Yi Wang, Chang-Yi Yen, Wan-Yu Sung, Cheng-Chin Wu, Tsan-Teng Ou, Wen-Chan Tsai, Wei-Ting Liao, Chung-Jen Chen, Su-Chen Lee, Shun-Jen Chang, Jeng-Hsien Yen
Summary: Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a severe manifestation of CTD that leads to significant morbidity and mortality. The disease can occur in diverse CTDs and is characterized by various histologic patterns. Abnormal immune system responses, especially in macrophages, play an important role in its pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Goncalo Boleto, Silje Reiseter, Anna-Maria Hoffmann-Vold, Adrien Mirouse, Patrice Cacoub, Marco Matucci-Cerinic, Manuel Silverio-Antonio, Joao Eurico Fonseca, Ana Catarina Duarte, Jorge Pestana Lopes, Valeria Riccieri, Alain Lescoat, Erwan Le Tallec, Ivan Castellvi Barranco, Jose Luis Tandaipan, Paolo Airo, Masataka Kuwana, Hoda Kavosi, Jerome Avouac, Yannick Allanore
Summary: This study compared predictive factors for interstitial lung disease (ILD) in patients with mixed connective tissue disease (MTCD) and found different factors associated with ILD. The study also found that MCTD-ILD patients have increased mortality and that digital ulcers (DU) are associated with progressive lung disease.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Review
Immunology
Nan-shu Xing, Guan-zhi Fan, Fei Yan, Yi-ping Liu, Rong Zhang
Summary: The efficacy and safety of RTX in CTD-ILD patients were systematically evaluated, showing RTX's superiority over conventional treatments, especially in improving forced vital capacity and MRSS in systemic sclerosis patients. RTX is able to improve or stabilize pulmonary function in CTD-ILD patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Kaifang Meng, Mi Tian, Xianhua Gui, Miaomiao Xie, Yujuan Gao, Shenyun Shi, Tingting Zhao, Yonglong Xiao, Hourong Cai, Jingjing Ding
Summary: This study found that the expression of HE4 in both serum and lung specimens was significantly elevated in CTD-ILD patients with UIP pattern. Serum HE4 levels were correlated with disease severity and prognosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Rheumatology
Hakeem Olaosebikan, Olufunke Adeyeye, Richard Akintayo, Akpabio Akpabio, Ajibade Adenitan, Olufemi Adelowo, Olufemi Ojo, Fasan-Odunsi Abimbola
Summary: This study conducted a retrospective survey of CTD-ILD patients in Lagos, finding a relatively low prevalence of 9.7% with a predominance of female patients. Common clinical features included cough and crackles, and treatments involved medications and oxygen therapy, with some patients at risk for mortality.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
David Roofeh, Kevin K. Brown, Ella A. Kazerooni, Donald Tashkin, Shervin Assassi, Fernando Martinez, Athol U. Wells, Ganesh Raghu, Christopher P. Denton, Lorinda Chung, Anna-Maria Hoffmann-Vold, Oliver Distler, Kerri A. Johannson, Yannick Allanore, Eric L. Matteson, Leticia Kawano-Dourado, John D. Pauling, James R. Seibold, Elizabeth R. Volkmann, Simon L. F. Walsh, Chester Oddis, Eric S. White, Shaney L. Barratt, Elana J. Bernstein, Robyn T. Domsic, Paul F. Dellaripa, Richard Conway, Ivan Rosas, Nitin Bhatt, Vivien Hsu, Francesca Ingegnoli, Bashar Kahaleh, Puneet Garcha, Nishant Gupta, Surabhi Khanna, Peter Korsten, Celia Lin, Stephen C. Mathai, Vibeke Strand, Tracy J. Doyle, Virginia Steen, Donald F. Zoz, Juan Ovalles-Bonilla, Ignasi Rodriguez-Pinto, Padmanabha D. Shenoy, Andrew Lewandoski, Elizabeth Belloli, Alain Lescoat, Vivek Nagaraja, Wen Ye, Suiyuan Huang, Toby Maher, Dinesh Khanna
Summary: This study aimed to establish a framework by which experts define disease subsets in systemic sclerosis associated interstitial lung disease (SSc-ILD). The results showed that using the proposed conceptual framework, international experts were able to achieve a consensus on classifying SSc-ILD patients along the dimensions of disease severity, risk of progression and progression over time.
Article
Medicine, General & Internal
Manuel Silverio-Antonio, Joana Martins-Martinho, Ana Teresa Melo, Francisca Guimaraes, Eduardo Dourado, Daniela Oliveira, Jorge Lopes, Andre Saraiva, Ana Gago, Margarida Correia, Ana L. Fernandes, Sara Dinis, Rafaela Teixeira, Susana P. Silva, Carlos Costa, Tiago Beirao, Carolina Furtado, Pedro Abreu, Carmo Afonso, Nikita Khmelinskii
Summary: This retrospective study aimed to identify predictors of interstitial lung disease (ILD) in patients with mixed connective tissue disease (MCTD). The study found that gastroesophageal involvement and lymphadenopathy at disease onset were associated with ILD. Additionally, it established that lymphadenopathy at disease onset and older age at diagnosis independently predicted ILD in MCTD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Giuliana Cerro Chiang, Tanyalak Parimon
Summary: CTD-ILD is a group of systemic autoimmune disorders that cause lung interstitial abnormalities or lung fibrosis. The pathogenesis of CTD-ILD is not well understood, but it shares common risk factors with idiopathic pulmonary fibrosis. The primary mechanism involves dysfunction of alveolar type II cells, triggering inflammatory cascades and leading to abnormal lung remodeling and fibrosis. Understanding these mechanisms is important for developing targeted therapies and identifying disease biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Francesca Motta, Antonio Tonutti, Natasa Isailovic, Angela Ceribelli, Giovanni Costanzo, Stefano Rodolfi, Carlo Selmi, Maria De Santis
Summary: Systemic sclerosis (SSc) is an autoimmune connective tissue disease with limited treatment options. This study utilized aptamer technology proteomic analysis to identify serum proteins associated with SSc manifestations. The results showed potential biomarkers for the early detection and prediction of SSc progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jake G. Natalini, Joshua M. Diamond, Mary K. Porteous, David J. Lederer, Keith M. Wille, Ann B. Weinacker, Jonathan B. Orens, Pali D. Shah, Vibha N. Lama, John F. McDyer, Laurie D. Snyder, Chadi A. Hage, Jonathan P. Singer, Lorraine B. Ware, Edward Cantu, Michelle Oyster, Laurel Kalman, Jason D. Christie, Steven M. Kawut, Elana J. Bernstein
Summary: This study compared the outcomes of lung transplantation in patients with CTD-ILD and IPF, finding that CTD-ILD patients had longer postoperative hospitalizations but no significant differences in grade 3 PGD and time to extubation compared to IPF patients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Review
Pharmacology & Pharmacy
Linrui Xu, Faping Wang, Fengming Luo
Summary: The meta-analysis study indicated that rituximab (RTX) has higher improvement and stable rates for CTD-ILD, especially for ASS-ILD and non-ASS IIM-ILD. Although RTX has a satisfactory safety profile, further randomized trials are needed to evaluate its efficacy compared to other treatments for CTD-ILD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Tingting Wu, Haijun Zhou, Suling Xu, Zaichun Deng, Yun Zhang, Qunli Ding
Summary: This study analyzed laboratory data and chest images of patients with ADM-ILD and other CTD-ILDs, aiming to find a characteristic index for early recognition of ADM-ILD and help clinicians consider this possibility as soon as possible.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Respiratory System
Adelle S. Jee, Robert Sheehy, Peter Hopkins, Tamera J. Corte, Christopher Grainge, Lauren K. Troy, Karen Symons, Lissa M. Spencer, Paul N. Reynolds, Sally Chapman, Sally de Boer, Taryn Reddy, Anne E. Holland, Daniel C. Chambers, Ian N. Glaspole, Helen E. Jo, Jane F. Bleasel, Jeremy P. Wrobel, Leona Dowman, Matthew J. S. Parker, Margaret L. Wilsher, Nicole S. L. Goh, Yuben Moodley, Gregory J. Keir
Summary: Pulmonary complications in CTD commonly involve various parts of the lungs and ILD can vary in severity, making accurate diagnosis and careful treatment decisions important. Management of CTD-ILD can be challenging due to limited data and the need for individualized approaches.
Article
Medicine, Research & Experimental
Ju Kwang Lee, Yura Ahn, Han Na Noh, Sang Min Lee, Bin Yoo, Chang-Keun Lee, Yong-Gil Kim, Seokchan Hong, Soo Min Ahn, Ho Cheol Kim
Summary: This study reviewed 197 patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) and found that progressive pulmonary fibrosis (PPF) was significantly associated with mortality, as well as increased rates of respiratory-related hospitalizations, pneumonia, acute exacerbations, and weight loss.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Respiratory System
Shuo Liu, Melody P. Chung, Brett Ley, Sarah French, Brett M. Elicker, David F. Fiorentino, Lorinda S. Chung, Francesco Boin, Paul J. Wolters
Summary: Peripheral blood leucocyte telomere length (PBL-TL) is associated with progression of systemic sclerosis-associated interstitial lung disease (SSc-ILD), with shorter PBL-TL potentially indicating higher risk of SSc-ILD progression. These findings suggest that telomere dysfunction may be associated with SSc-ILD progression, and PBL-TL measurement may be useful for stratifying risk for SSc-ILD progression.
Article
Rheumatology
Iago Pinal-Fernandez, Cassie Parks, Jessie L. Werner, Jemima Albayda, Julie J. Paik, Sonye K. Danoff, Livia Casciola-Rosen, Lisa Christopher-Stine, Andrew L. Mammen
ARTHRITIS CARE & RESEARCH
(2017)
Editorial Material
Rheumatology
Sonye K. Danoff
NATURE REVIEWS RHEUMATOLOGY
(2018)
Article
Clinical Neurology
Rebecca De Lorenzo, Iago Pinal-Fernandez, Wilson Huang, Jemima Albayda, Eleni Tiniakou, Cheilonda Johnson, Jose C. Milisenda, Maria Casal-Dominguez, Andrea M. Corse, Sonye K. Danoff, Lisa Christopher-Stine, Julie J. Paik, Andrew L. Mammen
Review
Rheumatology
Adam Schiffenbauer, Sara Faghihi-Kashani, Terrence P. O'Hanlon, Willy A. Flegel, Sharon D. Adams, Ira N. Targoff, Chester V. Oddis, Steven R. Ytterberg, Rohit Aggarwal, Lisa Christopher-Stine, Ejaz A. Shamim, Paul F. Dellaripa, Sonye K. Danoff, Andrew L. Mammen, Frederick W. Miller
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2018)
Article
Critical Care Medicine
Ganesh Raghu, Martine Remy-Jardin, Jeffrey L. Myers, Luca Richeldi, Christopher J. Ryerson, David J. Lederer, Juergen Behr, Vincent Cottin, Sonye K. Danoff, Ferran Morell, Kevin R. Flaherty, Athol Wells, Fernando J. Martinez, Arata Azuma, Thomas J. Bice, Demosthenes Bouros, Kevin K. Brown, Harold R. Collard, Abhijit Duggal, Liam Galvin, Yoshikazu Inoue, R. Gisli Jenkins, Takeshi Johkoh, Ella A. Kazerooni, Masanori Kitaichi, Shandra L. Knight, George Mansour, Andrew G. Nicholson, Sudhakar N. J. Pipavath, Ivette Buendia-Roldan, Moises Selman, William D. Travis, Simon Walsh, Kevin C. Wilson
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Article
Oncology
Karthik Suresh, Khinh Ranh Voong, Bairavi Shankar, Patrick M. Forde, David S. Ettinger, Kristen A. Marrone, Ronan J. Kelly, Christine L. Hann, Benjamin Levy, Josephine L. Feliciano, Julie R. Brahmer, David Feller-Kopman, Andrew D. Lerner, Hans Lee, Lonny Yarmus, Franco D'Alessio, Russell K. Hales, Cheng Ting Lin, Kevin J. Psoter, Sonye K. Danoff, Jarushka Naidoo
JOURNAL OF THORACIC ONCOLOGY
(2018)
Article
Immunology
Erika Darrah, Jon T. Giles, Ryan L. Davis, Pooja Naik, Hong Wang, Maximilian F. Konig, Laura C. Cappelli, Clifton O. Bingham, Sonye K. Danoff, Felipe Andrade
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Oncology
Karthik Suresh, Kevin J. Psoter, Khinh Ranh Voong, Bairavi Shankar, Patrick M. Forde, David S. Ettinger, Kristen A. Marrone, Ronan J. Kelly, Christine L. Hann, Benjamin Levy, Josephine L. Feliciano, Julie R. Brahmer, David Feller-Kopman, Andrew D. Lerner, Hans Lee, Lonny Yarmus, Russell K. Hales, Franco D'Alessio, Sonye K. Danoff, Jarushka Naidoo
JOURNAL OF THORACIC ONCOLOGY
(2019)
Article
Medicine, General & Internal
Ilene L. Hollin, Anne E. F. Dimmock, John F. P. Bridges, Sonye K. Danoff, Rebecca Bascom
PATIENT PREFERENCE AND ADHERENCE
(2019)
Article
Critical Care Medicine
Kerri Aronson, Sonye K. Danoff, Anne-Marie Russell, Christopher J. Ryerson, Atsushi Suzuki, Marlies S. Wijsenbeek, Sabrina Bajwah, Pauline Bianchi, Tamera J. Corte, Joyce S. Lee, Kathleen O. Lindell, Toby Maher, Fernando J. Martinez, Paula M. Meek, Ganesh Raghu, Glenda Rouland, Rick Rudell, Monika M. Safford, Jamie S. Sheth, Jeffrey J. Swigris
Summary: This study highlights the importance of patient-centered outcomes in ILD research and the need for more dedicated work in this area. The interdisciplinary group of experts identified key patient-centered outcomes and developed research recommendations to further advance this field. Despite progress made in understanding and treating ILD, there are still unanswered questions related to patient outcomes and therapies.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Letter
Critical Care Medicine
Cheilonda Johnson, Adam I. Schiffenbauer, Frederick W. Miller, Jamie Perin, Sonye K. Danoff, Avantika R. Diwadkar, Jaehyun Joo, Blanca E. Himes, Nuala J. Meyer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Critical Care Medicine
Robert W. Hallowell, Sonye K. Danoff
Summary: Although ILD is a major cause of morbidity and mortality in patients with inflammatory myopathies, the current definition and diagnostic criteria of autoimmune myositis are inadequate for identifying patients with lung-dominant disease. Autoantibodies play an emerging role in the diagnosis, classification, and management of ILD patients. However, standardized therapeutic approaches and prospective studies are needed to determine optimal treatment regimens for myositis-associated ILD.
Article
Critical Care Medicine
Christopher J. Ryerson, Tamera J. Corte, Joyce S. Lee, Luca Richeldi, Simon L. F. Walsh, Jeffrey L. Myers, Juergen Behr, Vincent Cottin, Sonye K. Danoff, Kevin R. Flaherty, David J. Lederer, David A. Lynch, Fernando J. Martinez, Ganesh Raghu, William D. Travis, Zarir Udwadia, Athol U. Wells, Harold R. Collard
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
Review
Rheumatology
Jacob T. Cox, David M. Gullotti, Christopher A. Mecoli, Arash H. Lahouti, Jemima Albayda, Julie Paik, Cheilonda Johnson, Sonye K. Danoff, Andrew L. Mammen, Lisa Christopher-Stine
CLINICAL RHEUMATOLOGY
(2017)
Review
Respiratory System
Julio A. Huapaya, Erin M. Wilfong, Christopher T. Harden, Roy G. Brower, Sonye K. Danoff
EUROPEAN RESPIRATORY REVIEW
(2018)