Review
Immunology
Charles E. Egwuagu, Sahar A. Alhakeem, Evaristus C. Mbanefo
Summary: Understanding the etiology and clinical management of potentially blinding diseases is crucial due to the significant impact of vision loss on human activities and quality of life. The unique anatomical features and immune sequestration of the eye have provided insights into studying diseases in immune privileged sites, leading to foundational discoveries in immunology. Advances in molecular cell biology and immunology over the past 3 decades have contributed to unraveling the mechanisms underlying the immunopathogenesis of uveitis, with particular emphasis on the development of biologics and cell-based immunotherapies for uveitis and other neuroinflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Rheumatology
Ioannis Sagonas, Dimitrios Daoussis
Summary: Serotonin plays a crucial role in fibrosis and vasculopathy in systemic sclerosis, suggesting the need for further exploration of its potential role in the disease.
Article
Chemistry, Multidisciplinary
Hui Hu, Wei Feng, Xiaoqin Qian, Luodan Yu, Yu Chen, Yuehua Li
Summary: The rapid growth of nanomedicine and nanobiotechnology has enabled the emergence of distinctive disease-specific therapeutic modalities, specifically nanomedicine-enabled/augmented nanodynamic therapy (NDT). These modalities include different approaches such as sonodynamic therapy, thermodynamic therapy, electrodynamic therapy, and others, aiming to enhance disease-specific treatment with reduced side effects.
ADVANCED MATERIALS
(2021)
Review
Immunology
Simone Caielli, Zurong Wan, Virginia Pascual
Summary: Autoreactive B cells and interferons play important roles in the development of systemic lupus erythematosus (SLE). Recent studies on genetics and immune monitoring of SLE patients have provided new insights into the underlying mechanisms, including novel gene mutations affecting B cell activation and clearance of interferogenic nucleic acids. Mitochondria have been identified as inducers or amplifiers of SLE through various mechanisms, leading to the release of interferogenic nucleic acids and activation of immune cells. Specific autoantibodies associated with monogenic lupus or triggering interferogenic amplification loops have been discovered. Additionally, atypical B cells and novel T helper cell subsets have been proposed to contribute to the generation of SLE autoantibodies. These findings offer opportunities for improved monitoring and personalized therapy for SLE patients.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Etienne Dardenne, Noboru Ishiyama, Tai -An Lin, Matthew C. Lucas
Summary: This article presents the mechanism of action, benefit, and potential mechanistic limitation of drugs currently being evaluated in clinical trials for achondroplasia, a rare disease affecting bone growth. It also discusses the potential impact of these drugs in increasing the growth of individuals with achondroplasia and improving their quality of life.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Immunology
Anais Nombel, Nicole Fabien, Frederic Coutant
Summary: Anti-MDA5 dermatomyositis is a rare systemic autoimmune disease with a diverse clinical spectrum, with three distinct clinical phenotypes defined by different prognosis. Specific antibodies targeting MDA5 are the only known molecular component shared by the three entities. Current knowledge on the pathogenic mechanisms of the disease is still in its infancy, but evidence supports a central role of interferon-mediated vasculopathy in lesion development.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Norio Chihara, Takashi Yamamura
Summary: Neuromyelitis optica (NMO) is an inflammatory disease similar to multiple sclerosis (MS), characterized by relapsing optic neuritis and myelitis. Autoantibodies against NMO play a crucial role in the inflammatory pathology involving proinflammatory cytokines and various inflammatory cells. Recent clinical trials have shown the efficacy of specific antibodies in preventing NMO relapses.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Review
Oncology
Josep M. Llovet, Roser Pinyol, Robin K. Kelley, Anthony El-Khoueiry, Helen L. Reeves, Xin Wei Wang, Gregory J. Gores, Augusto Villanueva
Summary: In this article, Llovet and colleagues review recent advances in hepatocellular carcinoma therapy and discuss the clinical workflows for selecting and monitoring patients. The article covers the molecular pathogenesis of HCC, molecular classes and determinants of heterogeneity, and effective systemic therapies including immunotherapy. The authors propose a flowchart of sequential therapies, explore mechanisms of resistance, and address the need for predictive biomarkers.
Review
Immunology
Thomas A. Premeaux, Stephen T. Yeung, Zaheer Bukhari, Scott Bowler, Oral Alpan, Raavi Gupta, Lishomwa C. Ndhlovu
Summary: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a significant global health emergency that can lead to multi-organ failure and death. Understanding the immunological processes is crucial for effective therapeutic interventions for high-risk patients. This review highlights the importance of caspase family members in SARS-CoV-2 infection and disease, suggesting that the function of multiple caspases is linked to the severity of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Maheswari Muruganandam, Angie Ariza-Hutchinson, Rosemina A. Patel, Wilmer L. Sibbitt
Summary: Systemic sclerosis is a complex autoimmune disease characterized by vascular damage, inflammation, and fibrosis. Biomarkers play an important role in understanding the disease process and potential therapeutic targets. Anti-nuclear antibodies are classical biomarkers, while other proteins and pathways are also implicated. The use of biomarker panels combined with advanced analysis techniques can help determine disease activity and treatment response.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Immunology
Krista D. DiSano, Francesca Gilli, Andrew R. Pachner
Summary: Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system, with B cells emerging as central players in the immune pathogenesis of the disease. Memory B cells (Bmem) are considered key B cell phenotypes in MS due to their antigen-experience, increased lifespan, and rapid response to stimulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Claire F. Beesley, Nina R. Goldman, Taher E. Taher, Christopher P. Denton, David J. Abraham, Rizgar A. Mageed, Voon H. Ong
Summary: Systemic sclerosis (SSc) is an immune-mediated rheumatic disease characterized by excessive extracellular matrix deposition. B cells play a fundamental role in the pathogenesis and development of SSc, as they infiltrate lesional sites and produce profibrotic cytokines. B cell counts are increased in SSc patients and show differences in various B cell compartments. B cell signaling is impaired in SSc patients, and B cell depletion therapy has shown therapeutic benefits.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Zizi Zhou, Wenxiang Chai, Yi Liu, Meng Zhou, Xiaoming Zhang
Summary: Connexins (Cxs) have crucial roles in cellular communication, affecting cell homeostasis, proliferation, and differentiation. The activity and expression of Cxs are linked to various clinical conditions, including carcinomas, cardiac disorders, and wound healing. Recent discoveries on the association between Cxs and angiogenesis have sparked interest in Cx-mediated angiogenesis due to its vital functions in tissue formation, wound repair, tumor growth, and metastasis. Understanding this association may lead to the development of targeted therapies for angiogenic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Iulia Szabo, Laura Muntean, Tania Crisan, Voicu Rednic, Claudia Sirbe, Simona Rednic
Summary: Systemic sclerosis (SSc) is a rare connective tissue disease with heterogeneous clinical phenotypes characterized by microangiopathy, immune dysfunction, and fibrosis. Epigenetic mechanisms and miRNAs play crucial roles in SSc pathogenesis, offering potential as biomarkers and therapeutic targets.
Article
Immunology
Xinglan He, Yaqian Shi, Zhuotong Zeng, Bingsi Tang, Xuan Xiao, Jiangfan Yu, Puyu Zou, Jiani Liu, Yangfan Xiao, Yangyang Luo, Rong Xiao
Summary: By conducting transcriptional sequencing on fibroblasts under hypoxic conditions, the study revealed that the interaction between hypoxia and other pathogenic factors is involved in the pathogenesis of SSc, providing insights into the mechanisms underlying the effects of hypoxia on SSc pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Emily-Ann Butler, Murray Baron, Agnes B. Fogo, Tracy Frech, Cybele Ghossein, Eric Hachulla, Sabrina Hoa, Sindhu R. Johnson, Dinesh Khanna, Luc Mouthon, Mandana Nikpour, Susanna Proudman, Virginia Steen, Edward Stern, John Varga, Christopher Denton, Marie Hudson, April Barnado, Murray Baron, Elana J. Bernstein, Francesco Boin, Yolanda Braun-Moscovici, Flavia V. Castelino, Luis J. Catoggio, Marco Matucci-Cerinic, Lorinda Chung, Philip Clements, Mary Ellen Csuka, Ellen De langhe, Christopher Denton, Joerg Distler, Oliver Distler, Dominique Claire Farge, Aryeh Fischer, Agnes B. Fogo, Tracy Frech, Armando Gabrielli, Cybele Ghossein, Eric Hachulla, Minoru Hasegawa, Samina Hayat, Ariane Herrick, Roger Hesselstrand, Sabrina Hoa, Vivien Hsu, Marie Hudson, Michael Hughes, Nicolas Hunzelmann, Laura Hummers, Florenzo Iannone, Francesca Ingegnoli, Soren Jacobsen, Sindhu R. Johnson, Yasushi Kawaguchi, Dinesh Khanna, Martial Koenig, Masataka Kuwana, Jan Lenaerts, Thierry Martin, Maureen D. Mayes, Zsuzsanna McMahan, Thomas Medsger, Peter Merkel, Sonali Narain, Mandana Nikpour, Voon Ong, John D. Pauling, Janet Pope, Susanna Proudman, Carlos de la Puente, Maureen Rischmueller, Tatiana Sofia Rodriguez-Reyna, Joanne Sahhar, Lesley Ann Saketkoo, Jean-Luc Senecal, Ankoor Shah, Ami A. Shah, Walter Alberto Sifuentes-Giraldo, Richard Silver, Virginia Steen, Edward Stern, Wendy Stevens, Evelyn Sutton, Vivek Thakkar, Gabriele Valentini, Jeska de Vries-Bouwstra, Madelon Vonk, Ulrich A. Walker
ARTHRITIS & RHEUMATOLOGY
(2019)
Article
Rheumatology
Chiara Bertolazzi, Angelica Vargas Guerrero, Tatiana Sofia Rodriguez-Reyna, Hugo Sandoval, Everardo Alvarez-Hernandez, Marcelo Jose Audisio, Eduardo Cabello, Paola Coral-Alvarado, Ericka Diaz, Virginia Duringan, Karinna Espejo, Selma Gallegos, Gabriela Hernandez-Molina, Blanca Herrera, Cristiane Kayser, Maria Eugenia Lara, Genessis Maldonado, Marta N. Mamani, Alejandro Nitsche, Carlos Rios-Acosta, Felix Enrique-Romanini, Maria Sormani de Fonseca, Veronica Silva Vilela, Miguel Angel Villarreal-Alarcon, Marwin Gutierrez
CLINICAL RHEUMATOLOGY
(2019)
Article
Rheumatology
Boyang Zheng, Tatiana Nevskaya, Carl A. Baxter, Dena R. Ramey, Janet E. Pope, Murray Baron, Marie Hudson, Genevieve Gyger, Maggie J. Larche, Nader A. Khalidi, Ariel Masetto, Evelyn Sutton, David Robinson, Tatiana S. Rodriguez-Reyna, Doug Smith, Carter Thorne, Paul R. Fortin, Marvin J. Fritzler
Article
Psychiatry
Brett D. Thombs, Linda Kwakkenbos, Marie-Eve Carrier, Angelica Bourgeault, Lydia Tao, Sami Harb, Maria Gagarine, Danielle Rice, Laura Bustamante, Kelsey Ellis, Delaney Duchek, Yin Wu, Parash Mani Bhandari, Dipika Neupane, Andrea Carboni-Jimenez, Richard S. Henry, Ankur Krishnan, Ying Sun, Brooke Levis, Chen He, Kimberly A. Turner, Andrea Benedetti, Nicole Culos-Reed, Ghassan El-Baalbaki, Shannon Hebblethwaite, Susan J. Bartlett, Laura Dyas, Scott Patten, John Varga, Catherine Fortune, Amy Gietzen, Genevieve Guillot, Nancy Lewis, Karen Nielsen, Michelle Richard, Maureen Sauve, Joep Welling, Murray Baron, Daniel E. Furst, Karen Gottesman, Vanessa Malcarne, Maureen D. Mayes, Luc Mouthon, Warren R. Nielson, Robert Riggs, Fredrick Wigley, Shervin Assassi, Isabelle Boutron, Carolyn Ells, Cornelia van den Ende, Kim Fligelstone, Tracy Frech, Dominique Godard, Daphna Harel, Monique Hinchcliff, Marie Hudson, Sindhu R. Johnson, Maggie Larche, Catarina Leite, Christelle Nguyen, Janet Pope, Alexandra Portales, Francois Rannou, Tatiana Sofia Rodriguez Reyna, Anne A. Schouffoer, Maria E. Suarez-Almazor, Christian Agard, Alexandra Albert, Marc Andre, Guylaine Arsenault, Ilham Benzidia, Elana J. Bernstein, Sabine Berthier, Lyne Bissonnette, Gilles Boire, Alessandra Bruns, Patricia Carreira, Marion Casadevall, Benjamin Chaigne, Lorinda Chung, Pascal Cohen, Chase Correia, Pierre Dagenais, Christopher Denton, Robyn Domsic, Sandrine Dubois, James Dunne, Bertrand Dunogue, Regina Fare, Dominique Farge-Bancel, Paul R. Fortin, Anna Gill, Jessica Gordon, Brigitte Granel-Rey, Genevieve Gyger, Eric Hachulla, Pierre-Yves Hatron, Ariane L. Herrick, Adrian Hij, Sabrina Hoa, Alena Ikic, Niall Jones, Artur Jose de B. Fernandes, Suzanne Kafaja, Nader Khalidi, Marc Lambert, David Launay, Patrick Liang, Helene Maillard, Nancy Maltez, Joanne Manning, Isabelle Marie, Maria Martin, Thierry Martin, Ariel Masetto, Francois Maurier, Arsene Mekinian, Sheila Melchor, Mandana Nikpour, Louis Olagne, Vincent Poindron, Susanna Proudman, Alexis Regent, Sebastien Riviere, David Robinson, Esther Rodriguez, Sophie Roux, Perrine Smets, Doug Smith, Vincent Sobanski, Robert Spiera, Virginia Steen, Wendy Stevens, Evelyn Sutton, Benjamin Terrier, Carter Thorne, Pearce Wilcox, Mara Canedo Ayala, Nora Ostbo
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Miguel Ramirez-Aragon, Fernando Hernandez-Sanchez, Tatiana S. Rodriguez-Reyna, Ivette Buendia-Roldan, Gael Guitron-Castillo, Carlos A. Nunez-Alvarez, Diego F. Hernandez-Ramirez, Sergio A. Benavides-Suarez, Alexia Esquinca-Gonzalez, Ana Lilia Torres-Machorro, Criselda Mendoza-Milla
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Rheumatology
Adrian E. Caballero-Islas, Irma Hoyo-Ulloa, Annette Garcia-Castro, Andrea Hinojosa-Azaola
RHEUMATOLOGY INTERNATIONAL
(2020)
Article
Biology
Bruce A. Rosa, Mushtaq Ahmed, Dhiraj K. Singh, Jose Alberto Choreno-Parra, Journey Cole, Luis Armando Jimenez-Alvarez, Tatiana Sofia Rodriguez-Reyna, Bindu Singh, Olga Gonzalez, Ricardo Carrion, Larry S. Schlesinger, John Martin, Joaquin Zuniga, Makedonka Mitreva, Deepak Kaushal, Shabaana A. Khader
Summary: The study discovered that genes associated with Interferon signaling, neutrophil degranulation, and innate immune pathways are induced in the lungs of macaques in response to SARS-CoV-2 infection, while genes related to collagen formation and regulation are reduced. Age is identified as a significant risk factor for poor prognosis and increased mortality in COVID-19.
COMMUNICATIONS BIOLOGY
(2021)
Article
Health Care Sciences & Services
Marie-Eve Carrier, Linda Kwakkenbos, Warren R. Nielson, Claire Fedoruk, Karen Nielsen, Katherine Milette, Janet Pope, Tracy Frech, Shadi Gholizadeh, Laura Hummers, Sindhu R. Johnson, Pamela Piotrowski, Lisa Jewett, Jessica Gordon, Lorinda Chung, Dan Bilsker, Kimberly A. Turner, Julie Cumin, Joep Welling, Catherine Fortune, Catarina Leite, Karen Gottesman, Maureen Sauve, Tatiana S. Rodriguez-Reyna, Marie Hudson, Maggie Larche, Ward van Breda, Maria E. Suarez-Almazor, Susan J. Bartlett, Vanessa L. Malcarne, Maureen D. Mayes, Isabelle Boutron, Luc Mouthon, Fredrick Wigley, Brett D. Thombs
JMIR RESEARCH PROTOCOLS
(2020)
Article
Rheumatology
Boyang Zheng, Marie Hudson, Mianbo Wang, Murray Baron, Janet E. Pope, Murray Baron, Genevieve Gyger, Maggie J. Larche, Nader A. Khalidi, Ariel Masetto, Evelyn Sutton, David Robinson, Tatiana S. Rodriguez-Reyna, Nancy Maltez, Doug Smith, Carter Thorne, Alena Ikic, Paul R. Fortin, Marvin J. Fritzler
ARTHRITIS RESEARCH & THERAPY
(2020)
Article
Rheumatology
Jessica Salituri, Natalie Patey, Tomoko Takano, Pierre Fiset, Sonia Del Rincon, Laeora Berkson, Murray Baron, Marie Hudson, M. Baron, M. Hudson, G. Gyger, J. Pope, M. Larche, N. Khalidi, A. Masetto, E. Sutton, D. Robinson, T. S. Rodriguez-Reyna, D. Smith, C. Thorne, P. R. Fortin, M. Fritzler
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2020)
Meeting Abstract
Rheumatology
Antonia Valenzuela, Melody Chung, Tatiana S. Rodriguez-Reyna, Susanna Proudman, Murray Baron, Flavia Castelino, Vivien Hsu, Shufeng Li, David Fiorentino, Kathryn Stevens, Lorinda Chung
ARTHRITIS & RHEUMATOLOGY
(2019)
Meeting Abstract
Rheumatology
Chiara Bertolazzi, Marwin Gutierrez, Angelica Vargas, Tatiana Sofia Rodriguez-Reyna, Hugo Sandoval, Everardo Alvarez-Hernandez, Marcelo Audisio, Eduardo Cabello, Paola Coral, Ericka Diaz, Virginia Duringa, Katirma Espejo, Selma Gallegos, Gabriela Hernandez-Molina, Blanca Herrera, Cristiane Kayser, Maria Eugenia Lara, Genessis Maldonado, Marta N. Mamani, Alejandro Nitsche, Carlos Rios-Acosta, Felix Enrique-Romanini, Maria Sormani de Fonseca, Veronica Vilela, Miguel Villarreal
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2019)
Meeting Abstract
Critical Care Medicine
J. Rojas-Serrano, D. Fernandez-Badillo, D. I. Perez-Romam, L. E. Vazquez-Becerra, M. Mejia, H. N. Mateos-Toledo, L. Figueroa-Hernandez, T. S. Rodriguez-Reyna, K. Balderas-Munoz
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Meeting Abstract
Critical Care Medicine
D. Khanna, C. J. F. Lin, J. Goldin, G. Kim, M. Kuwana, Y. Allanore, A. Batalov, I. Butrimiene, P. Carreira, M. Matucci-Cerinic, O. Distler, D. Martinovic Kaliterna, C. Mihai, M. Mogensen, M. Olesinska, J. E. Pope, G. Riemekasten, T. Rodriguez-Reyna, M. J. Santos, J. van Laar, H. Spotswood, J. Siegel, A. Jahreis, D. Furst, C. P. Denton
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
