Bletilla striata Polysaccharide Promotes Diabetic Wound Healing Through Inhibition of the NLRP3 Inflammasome

High Glucose‐Aggravated Hepatic Insulin Resistance: Role of the NLRP3 Inflammasome in Kupffer Cells

(2020) Tao Zheng et al.   Obesity

Bletilla striata oligosaccharides improve metabolic syndrome through modulation of gut microbiota and intestinal metabolites in high fat diet-fed mice

(2020) Baifei Hu et al.   PHARMACOLOGICAL RESEARCH

MFG-E8 accelerates wound healing in diabetes by regulating “NLRP3 inflammasome-neutrophil extracellular traps” axis

(2020) Wei Huang et al.   Cell Death Discovery

NLRP3 Activation Induced by Neutrophil Extracellular Traps Sustains Inflammatory Response in the Diabetic Wound

(2019) Dan Liu et al.   CLINICAL SCIENCE

Chemical characterization and gastroprotective effect of an isolated polysaccharide fraction from Bletilla striata against ethanol-induced acute gastric ulcer

(2019) Chen Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice

(2019) Chen Zhang et al.   Evidence-based Complementary and Alternative Medicine

Structural characterization and antioxidant activity of a new polysaccharide from Bletilla striata fibrous roots

(2019) Ziyan Chen et al.   CARBOHYDRATE POLYMERS

Polysaccharides from tubers of Bletilla striata: Physicochemical characterization, formulation of buccoadhesive wafers and preliminary study on treating oral ulcer

(2018) Zhencheng Liao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Extraction, characterization, utilization as wound dressing and drug delivery of Bletilla striata polysaccharide: A review

(2018) Ziyan Chen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway

(2018) Tao Zheng et al.   Oxidative Medicine and Cellular Longevity

Estimation of global insulin use for type 2 diabetes, 2018–30: a microsimulation analysis

(2018) Sanjay Basu et al.   Lancet Diabetes & Endocrinology

Structural characterization and immunological activity of polysaccharides from the tuber of Bletilla striata

(2018) Yirui Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Bletilla striata: Medicinal uses, phytochemistry and pharmacological activities

(2017) Xirui He et al.   JOURNAL OF ETHNOPHARMACOLOGY

Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing

(2017) Anna E. Boniakowski et al.   JOURNAL OF IMMUNOLOGY

Synthesis, Characterization, and the Antioxidant Activity of Double Quaternized Chitosan Derivatives

(2017) Lijie Wei et al.   MOLECULES

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

NLRP3 Inflammasome Expression and Signaling in Human Diabetic Wounds and in High Glucose Induced Macrophages

(2017) Xiaotian Zhang et al.   Journal of Diabetes Research

TNF-α stimulates endothelial palmitic acid transcytosis and promotes insulin resistance

(2017) Wenjing Li et al.   Scientific Reports

Silencing TNFα with lipidoid nanoparticles downregulates both TNFα and MCP-1 in an in vitro co-culture model of diabetic foot ulcers

(2016) Lisa N. Kasiewicz et al.   Acta Biomaterialia

Bletilla striata polysaccharide inhibits angiotensin II-induced ROS and inflammation via NOX4 and TLR2 pathways

(2016) Long Yue et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway

(2015) Tao Zheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling

(2015) Woo Je Lee et al.   DIABETES

Hydrogen Sulfide Improves Wound Healing via Restoration of Endothelial Progenitor Cell Functions and Activation of Angiopoietin-1 in Type 2 Diabetes

(2014) Fang Liu et al.   DIABETES

Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice

(2013) Alessandra Bitto et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice

(2013) R. E. Mirza et al.   DIABETES

Blocking Interleukin-1  Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes

(2013) R. E. Mirza et al.   DIABETES

A study on ethosomes as mode for transdermal delivery of an antidiabetic drug

(2013) Siddhodhan S. Bodade et al.   DRUG DELIVERY

Mechanisms Involved in the Development and Healing of Diabetic Foot Ulceration

(2012) T. Dinh et al.   DIABETES

Diabetes-impaired wound healing and altered macrophage activation: A possible pathophysiologic correlation

(2012) Mingyuan Miao et al.   WOUND REPAIR AND REGENERATION

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats

(2011) Tao Zheng et al.   JOURNAL OF ETHNOPHARMACOLOGY

A physiologically active polysaccharide hydrogel promotes wound healing

(2010) Yi Luo et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice

(2010) Eric J. Marrotte et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel mucoadhesive polysaccharide isolated fromBletilla striataimproves the intraocular penetration and efficacy of levofloxacin in the topical treatment of experimental bacterial keratitis

(2010) Xiang-gen Wu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Glucose-stimulated Expression of Txnip Is Mediated by Carbohydrate Response Element-binding Protein, p300, and Histone H4 Acetylation in Pancreatic Beta Cells

(2009) Hyunjoo Cha-Molstad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY