Effects of Real-Ambient PM2.5 Exposure on Lung Damage Modulated by Nrf2−/−

Nrf2 deficiency aggravates PM2.5-induced cardiomyopathy by enhancing oxidative stress, fibrosis and inflammation via RIPK3-regulated mitochondrial disorder

(2020) Chenxu Ge et al.   Aging-US

Ambient PM2.5 caused cardiac dysfunction through FoxO1-targeted cardiac hypertrophy and macrophage-activated fibrosis in mice

(2020) Xuan Su et al.   CHEMOSPHERE

Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response

(2020) Kaitlyn A Sun et al.   eLife

Real-Ambient Particulate Matter Exposure-Induced Cardiotoxicity in C57/B6 Mice

(2020) Lianhua Cui et al.   Frontiers in Pharmacology

Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

(2020) Daochuan Li et al.   Particle and Fibre Toxicology

Real-ambient exposure to air pollution exaggerates excessive growth of adipose tissue modulated by Nrf2 signal

(2020) Menghui Jiang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Chemical identity and cardiovascular toxicity of hydrophobic organic components in PM2.5

(2020) Zenghua Qi et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury

(2020) Rachel Stading et al.   Expert Opinion on Drug Metabolism & Toxicology

Nrf2 modulated the restriction of lung function via impairment of intrinsic autophagy upon real-ambient PM2.5 exposure

(2020) Menghui Jiang et al.   JOURNAL OF HAZARDOUS MATERIALS

The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

(2019) Seyed Mojtaba GHIASI et al.   DIABETES

Multiple organ injury in male C57BL/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China

(2019) Daochuan Li et al.   ENVIRONMENTAL POLLUTION

Endoplasmic Reticulum Stress-induced Upregulation of STARD1 Promotes Acetaminophen-induced Acute Liver Failure

(2019) Sandra Torres et al.   GASTROENTEROLOGY

Pulmonary toxicities from a 90-day chronic inhalation study with carbon black nanoparticles in rats related to the systemical immune effects

(2019) Chen Chu et al.   International Journal of Nanomedicine

Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells

(2019) Oleksiy Klymenko et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

N-acetylcysteine attenuates PM2.5-induced apoptosis by ROS-mediated Nrf2 pathway in human embryonic stem cells

(2019) Lifang Jin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Nrf2 in cancers: A double‐edged sword

(2019) Shijia Wu et al.   Cancer Medicine

Colonic Injuries Induced by Inhalational Exposure to Particulate‐Matter Air Pollution

(2019) Xiaobo Li et al.   Advanced Science

Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy

(2019) Wenhui Yue et al.   Redox Biology

A systematic review of cardiovascular responses associated with ambient black carbon and fine particulate matter

(2019) E.F. Kirrane et al.   ENVIRONMENT INTERNATIONAL

Exposure of trophoblast cells to fine particulate matter air pollution leads to growth inhibition, inflammation and ER stress

(2019) Mary Familari et al.   PLoS One

The essential role of CYP2E1 in metabolism and hepatotoxicity of N,N-dimethylformamide using a novel Cyp2e1 knockout mouse model and a population study

(2019) Zhijun Wu et al.   ARCHIVES OF TOXICOLOGY

Association Between Long-term Exposure to Ambient Air Pollution and Change in Quantitatively Assessed Emphysema and Lung Function

(2019) Meng Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

PM2.5 concentration in the ambient air is a risk factor for the development of high-risk coronary plaques

(2019) Seokhun Yang et al.   European Heart Journal-Cardiovascular Imaging

Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models

(2019) F. Oesch et al.   ARCHIVES OF TOXICOLOGY

Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response

(2019) Yuning Lin et al.   BIOMEDICINE & PHARMACOTHERAPY

Epigallocatechin-3-Gallate Reduces Hepatic Oxidative Stress and Lowers CYP-Mediated Bioactivation and Toxicity of Acetaminophen in Rats

(2019) Hsien-Tsung Yao et al.   Nutrients

Long-Term Exposure to Ambient Fine Particulate Matter (PM2.5) and Lung Function in Children, Adolescents, and Young Adults: A Longitudinal Cohort Study

(2019) Cui Guo et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Endoplasmic reticulum stress is involved in ventilator-induced lung injury in mice via the IRE1α-TRAF2-NF-κB pathway

(2019) Liu Ye et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

PM2.5 induces autophagy and apoptosis through endoplasmic reticulum stress in human endothelial cells

(2019) Yan Wang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARγ expression

(2019) Lu Li et al.   Redox Biology

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Instillation of particulate matter 2.5 induced acute lung injury and attenuated the injury recovery in ACE2 knockout mice

(2018) Chung-I Lin et al.   International Journal of Biological Sciences

Nrf2 deficiency exacerbates PM2.5-induced olfactory bulb injury

(2018) Xiaoyu Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ethanolic extract of Cordyceps cicadae exerts antitumor effect on human gastric cancer SGC-7901 cells by inducing apoptosis, cell cycle arrest and endoplasmic reticulum stress

(2018) Hongqing Xie et al.   JOURNAL OF ETHNOPHARMACOLOGY

PM2.5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183/96/182 cluster targeting FOXO1 in mouse

(2018) Lixiao Zhou et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Effects of PM2.5 exposure on the Notch signaling pathway and immune imbalance in chronic obstructive pulmonary disease

(2017) Xing-yu Gu et al.   ENVIRONMENTAL POLLUTION

Exposure scenario: Another important factor determining the toxic effects of PM2.5 and possible mechanisms involved

(2017) Wei Zhou et al.   ENVIRONMENTAL POLLUTION

Toxicological implications of mitochondrial localization of CYP2E1

(2017) Jessica H. Hartman et al.   Toxicology Research

Exposure to Fine Particulate Air Pollution Is Associated With Endothelial Injury and Systemic InflammationNovelty and Significance

(2016) C. Arden Pope et al.   CIRCULATION RESEARCH

Development of a RNA-Seq Based Prognostic Signature in Lung Adenocarcinoma

(2016) Sudhanshu Shukla et al.   JNCI-Journal of the National Cancer Institute

Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

(2016) Izaskun Buendia et al.   PHARMACOLOGY & THERAPEUTICS

Recent Structural Insights into Cytochrome P450 Function

(2016) F. Peter Guengerich et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Development of a RNA-Seq Based Prognostic Signature in Lung Adenocarcinoma

(2016) Sudhanshu Shukla et al.   JNCI-Journal of the National Cancer Institute

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy

(2015) André M. Cantin et al.   Journal of Cystic Fibrosis

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5

(2014) Takashi Ashino et al.   Redox Biology

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

Quantifying the Sources of the Severe Haze over the Southern Hebei Using the CMAQ Model

(2013) Jing Yang et al.   TheScientificWorldJOURNAL

An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals

(2011) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues

(2010) Suzette Laing et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters

(2009) Guoxiang Shen et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Ambient Air Pollution Particles and the Acute Exacerbation of Chronic Obstructive Pulmonary Disease

(2008) Thaw Sint et al.   INHALATION TOXICOLOGY

Air pollution particulate matter (PM2.5)-induced gene expression of volatile organic compound and/or polycyclic aromatic hydrocarbon-metabolizing enzymes in an in vitro coculture lung model

(2008) Imane Abbas et al.   TOXICOLOGY IN VITRO

Gene expression induction of volatile organic compound and/or polycyclic aromatic hydrocarbon-metabolizing enzymes in isolated human alveolar macrophages in response to airborne particulate matter (PM2.5)

(2007) Françoise Saint-Georges et al.   TOXICOLOGY