Toxicological implications of mitochondrial localization of CYP2E1

1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice

(2017) Jessica H. Hartman et al.   TOXICOLOGY

Protective role of garlic oil against oxidative damage induced by furan exposure from weaning through adulthood in adult rat testis

(2016) Gehan El-Akabawy et al.   ACTA HISTOCHEMICA

Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis

(2016) Takaya Shirato et al.   ARCHIVES OF TOXICOLOGY

Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen

(2016) Anne van Rongen et al.   CLINICAL PHARMACOKINETICS

Mitochondrial Signaling and Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Implications

(2016) Antonio Facciorusso et al.   CURRENT PHARMACEUTICAL DESIGN

A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen

(2016) Anaïs Michaut et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cytochrome P450 expression in mouse brain: specific isoenzymes involved in Phase I metabolizing system of porphyrinogenic agents in both microsomes and mitochondria

(2015) Jimena Lavandera et al.   Biochemistry and Cell Biology

Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1

(2015) PSS Rao et al.   CURRENT DRUG METABOLISM

Mitochondrial oxidative stress and dysfunction induced by isoniazid: study on isolated rat liver and brain mitochondria

(2015) Morteza Ahadpour et al.   DRUG AND CHEMICAL TOXICOLOGY

Induction of CYP2E1 in non-alcoholic fatty liver diseases

(2015) Ghanim Aljomah et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Acrylamide induces mitochondrial dysfunction and apoptosis in BV-2 microglial cells

(2015) Zhigang Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol enhanced anticancer effects of cisplatin on non-small cell lung cancer cell lines by inducing mitochondrial dysfunction and cell apoptosis

(2015) LIJIE MA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Iron-induced myocardial injury: an alarming side effect of superparamagnetic iron oxide nanoparticles

(2015) Yunli Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

C-phycocyanin prevents cisplatin-induced mitochondrial dysfunction and oxidative stress

(2015) Berenice Fernández-Rojas et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The genetic consequences of paternal acrylamide exposure and potential for amelioration

(2015) Aimee L. Katen et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Dysregulated metabolism contributes to oncogenesis

(2015) Matthew D. Hirschey et al.   SEMINARS IN CANCER BIOLOGY

Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates

(2015) Jessica H. Hartman et al.   TOXICOLOGY

Inhibitory mechanisms of celastrol on human liver cytochrome P450 1A2, 2C19, 2D6, 2E1 and 3A4

(2015) Chunhuan Jin et al.   XENOBIOTICA

Drug metabolism enzymes in a steatotic model of rat treated with a high fat diet and a low dose of streptozotocin

(2014) A. Vornoli et al.   FOOD AND CHEMICAL TOXICOLOGY

CYP2E1 Impairs GLUT4 Gene Expression and Function: NRF2 as a Possible Mediator

(2014) M. Armoni et al.   HORMONE AND METABOLIC RESEARCH

The Polymorphism of CYP2E1 Rsa I/Pst I Gene and Susceptibility to Respiratory System Cancer

(2014) Li Xu et al.   MEDICINE

Association between the CYP2E1 polymorphisms and lung cancer risk: a meta-analysis

(2014) Xiang-Hua Ye et al.   MOLECULAR GENETICS AND GENOMICS

Human CYP2E1-dependent and human sulfotransferase 1A1-modulated induction of micronuclei by benzene and its hydroxylated metabolites in Chinese hamster V79-derived cells

(2014) Hao Jiang et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression

(2014) B. Boussadia et al.   NEUROSCIENCE

Tempol, a Superoxide Dismutase Mimetic Agent, Ameliorates Cisplatin-Induced Nephrotoxicity through Alleviation of Mitochondrial Dysfunction in Mice

(2014) Lamiaa A. Ahmed et al.   PLoS One

CYP2E1 induction leads to oxidative stress and cytotoxicity in glutathione-depleted cerebellar granule neurons

(2014) Ana Carolina Valencia-Olvera et al.   TOXICOLOGY IN VITRO

The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts

(2014) Kirsten Linhart et al.   Redox Biology

Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications

(2014) Byoung-Joon Song et al.   Redox Biology

Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling

(2014) Jörn M. Schattenberg et al.   Redox Biology

CYP2E1 RsaI/PstI Polymorphism and Liver Cancer Risk among East Asians: a Huge Review and Meta-analysis

(2013) Zhong Tian et al.   Asian Pacific Journal of Cancer Prevention

CYP2E1 hydroxylation of aniline involves negative cooperativity

(2013) Jessica H. Hartman et al.   BIOCHEMICAL PHARMACOLOGY

Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes

(2013) Kang Kwang Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Human Cytochrome P450 2E1 Mutations That Alter Mitochondrial Targeting Efficiency and Susceptibility to Ethanol-induced Toxicity in Cellular Models

(2013) Seema Bansal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective effect of geraniol and curcumin in an acrylamide model of neurotoxicity in Drosophila melanogaster: Relevance to neuropathy

(2013) Sathya N. Prasad et al.   JOURNAL OF INSECT PHYSIOLOGY

Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

(2013) Rossella Marullo et al.   PLoS One

Mitochondria as a Target of Environmental Toxicants

(2013) Joel N. Meyer et al.   TOXICOLOGICAL SCIENCES

CYP2E1 polymorphisms and colorectal cancer risk: a HuGE systematic review and meta-analysis

(2013) Ou Jiang et al.   TUMOR BIOLOGY

Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma

(2013) Chia-Chi Hsu   WORLD JOURNAL OF GASTROENTEROLOGY

Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis

(2012) Rong-Huai Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metabolism and Toxicity of Thioacetamide and Thioacetamide S-Oxide in Rat Hepatocytes

(2012) Heather Hajovsky et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mitaplatin Increases Sensitivity of Tumor Cells to Cisplatin by Inducing Mitochondrial Dysfunction

(2012) Xue Xue et al.   MOLECULAR PHARMACEUTICS

Functional PstI/RsaI Polymorphism in CYP2E1 Is Associated with the Development, Progression and Poor Outcome of Gastric Cancer

(2012) Jin Feng et al.   PLoS One

Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem

(2012) Yanjun Zhong et al.   TOXICOLOGY

Rat liver mitochondrial damage under acute or chronic carbon tetrachloride-induced intoxication: Protection by melatonin and cranberry flavonoids

(2012) V.T. Cheshchevik et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

(2012) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Solvent exposures and parkinson disease risk in twins

(2011) Samuel M. Goldman et al.   ANNALS OF NEUROLOGY

Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice

(2011) Wei Zhang et al.   FEBS Journal

Taurine Is More Effective than Melatonin on Cytochrome P450 2E1 and Some Oxidative Stress Markers in Streptozotocin-Induced Diabetic Rats

(2011) Manal El-Batch et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Thioacetamide-Induced Fulminant Hepatic Failure Induces Cerebral Mitochondrial Dysfunction by Altering the Electron Transport Chain Complexes

(2011) Kiranmai Chadipiralla et al.   NEUROCHEMICAL RESEARCH

Mitochondrial dysfunction in obesity

(2011) Juan C Bournat et al.   Current Opinion in Endocrinology Diabetes and Obesity

Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role

(2011) J. Aubert et al.   Clinics and Research in Hepatology and Gastroenterology

1,3-Butadiene: I. Review of metabolism and the implications to human health risk assessment

(2010) Christopher R. Kirman et al.   CRITICAL REVIEWS IN TOXICOLOGY

Trichloroethylene and Parkinson’s disease: dissolving the puzzle

(2010) Samuel M Goldman   Expert Review of Neurotherapeutics

Cytochrome P4502E1 (CYP2E1) Genetic Polymorphisms in a Lebanese Population: Frequency Distribution and Association with Morbid Diseases

(2010) Nathalie Khoueiry Zgheib et al.   Genetic Testing and Molecular Biomarkers

Mitochondria-targeted Cytochrome P450 2E1 Induces Oxidative Damage and Augments Alcohol-mediated Oxidative Stress

(2010) Seema Bansal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence of Oxidative Stress and Associated DNA Damage, Increased Proliferative Drive, and Altered Gene Expression in Rat Liver Produced by the Cholangiocarcinogenic Agent Furan

(2010) K. C. Hickling et al.   TOXICOLOGIC PATHOLOGY

Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen

(2010) Laetitia Knockaert et al.   TOXICOLOGY IN VITRO

Cellular and Mitochondrial Effects of Alcohol Consumption

(2010) Salvador Manzo-Avalos et al.   International Journal of Environmental Research and Public Health

Protection against Hepatocyte Mitochondrial Dysfunction Delays Fibrosis Progression in Mice

(2009) Claudia Mitchell et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial Glutathione, a Key Survival Antioxidant

(2009) Montserrat Marí et al.   ANTIOXIDANTS & REDOX SIGNALING

Association between CYP2E1 genetic polymorphisms and lung cancer risk: A meta-analysis

(2009) Yadong Wang et al.   EUROPEAN JOURNAL OF CANCER

Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease

(2009) Elango Kathirvel et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats

(2009) Mei Liu et al.   JOURNAL OF NEUROCHEMISTRY

Genetic Polymorphism in CYP2E1: Population Distribution of CYP2E1 Activity

(2009) Pat Neafsey et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Distribution and Differential Induction of CYP2E1 by Ethanol and Acetone in the Mesocorticolimbic System of Rat

(2008) M. J. Sanchez-Catalan et al.   ALCOHOL AND ALCOHOLISM

Human CYP2E1 mediates the formation of glycidamide from acrylamide

(2008) Eva Settels et al.   ARCHIVES OF TOXICOLOGY

Association between mitochondrial DNA copy number, blood cell counts, and occupational benzene exposure

(2008) Min Shen et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Advances in the interpretation and prediction of CYP2E1 metabolism from a biochemical perspective

(2008) Grover P Miller   Expert Opinion on Drug Metabolism & Toxicology

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity

(2007) Don M. Gash et al.   ANNALS OF NEUROLOGY

Role of CYP2E1 in thioacetamide-induced mouse hepatotoxicity

(2007) Jin Seok Kang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY