Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells

HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis

(2018) Eva Delbrel et al.   Scientific Reports

Unifying mechanism for different fibrotic diseases

(2017) Gerlinde Wernig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lung fibrosis-associated soluble mediators and bronchoalveolar lavage from idiopathic pulmonary fibrosis patients promote the expression of fibrogenic factors in subepithelial lung myofibroblasts

(2017) Evangelos Bouros et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The JNK Signaling Pathway in Renal Fibrosis

(2017) Keren Grynberg et al.   Frontiers in Physiology

GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis

(2016) Ehab A Ayaub et al.   JOURNAL OF PATHOLOGY

Chop Deficiency Protects Mice Against Bleomycin-induced Pulmonary Fibrosis by Attenuating M2 Macrophage Production

(2016) Yingying Yao et al.   MOLECULAR THERAPY

CCAAT-Enhancer-Binding Protein Homologous Protein Deficiency Attenuates Oxidative Stress and Renal Ischemia-Reperfusion Injury

(2015) Bo Lin Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice

(2015) Yuta Tanaka et al.   PHARMACOLOGICAL RESEARCH

Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1/TLR4/NFκB/IL-1β signaling

(2015) M Zhang et al.   Cell Death & Disease

HMGB1 mediates hyperglycaemia-induced cardiomyocyte apoptosisviaERK/Ets-1 signalling pathway

(2014) Wen-Ke Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Thrombin Increases Lung Fibroblast Survival while Promoting Alveolar Epithelial Cell Apoptosis via the Endoplasmic Reticulum Stress Marker, CCAAT Enhancer–Binding Homologous Protein

(2013) Ilia Atanelishvili et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT/enhancer-binding protein homologous protein deficiency

(2013) Kan Toriguchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

(2013) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis

(2012) Seung-Ick Cha et al.   RESPIRATORY RESEARCH

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

C/EBP Homologous Protein Deficiency Attenuates Myocardial Reperfusion Injury by Inhibiting Myocardial Apoptosis and Inflammation

(2011) Yuji Miyazaki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress

(2011) L Dong et al.   ONCOGENE

Surfactant Protein A2 Mutations Associated with Pulmonary Fibrosis Lead to Protein Instability and Endoplasmic Reticulum Stress

(2010) Meenakshi Maitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Positive Role of CCAAT/Enhancer-Binding Protein Homologous Protein, a Transcription Factor Involved in the Endoplasmic Reticulum Stress Response in the Development of Colitis

(2009) Takushi Namba et al.   AMERICAN JOURNAL OF PATHOLOGY

Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection

(2008) William E. Lawson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Epithelial Endoplasmic Reticulum Stress and Apoptosis in Sporadic Idiopathic Pulmonary Fibrosis

(2008) Martina Korfei et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

C/EBP homologous protein is crucial for the acceleration of experimental pancreatitis

(2008) Koichi Suyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic reticulum stress in the kidney

(2008) Masanori Kitamura   Clinical and Experimental Nephrology

Brefeldin A activates CHOP promoter at the AARE, ERSE and AP-1 elements

(2008) Simon C. M. Kwok et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY