Improving the Dysregulation of FoxO1 Activity Is a Potential Therapy for Alleviating Diabetic Kidney Disease

Diabetic Kidney Disease

(2020) Ryan Bonner et al.   PRIMARY CARE

Endothelium structure and function in kidney health and disease

(2019) Noemie Jourde-Chiche et al.   Nature Reviews Nephrology

FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX

(2019) Linlin Ji et al.   Oxidative Medicine and Cellular Longevity

Role of sirtuin-1 in diabetic nephropathy

(2019) Wanning Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Targeting VE-PTP phosphatase protects the kidney from diabetic injury

(2019) Isabel A. Carota et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Atrasentan alleviates high glucose-induced podocyte injury by the microRNA-21/forkhead box O1 axis

(2019) Jie Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

(2019) Maria Saline et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy

(2019) Di Zhou et al.   Cell Death & Disease

FoxO1-mediated inhibition of STAT1 alleviates tubulointerstitial fibrosis and tubule apoptosis in diabetic kidney disease

(2019) Fengjuan Huang et al.   EBioMedicine

Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway

(2019) Huiwen Ren et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Long non-coding RNA MALAT1 interacts with transcription factor Foxo1 to regulate SIRT1 transcription in high glucose-induced HK-2 cells injury

(2018) Ling Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Liraglutide ameliorates early renal injury by the activation of renal FoxO1 in a type 2 diabetic kidney disease rat model

(2018) Pin Chen et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The Evolving Importance of Insulin Signaling in Podocyte Health and Disease

(2018) Abigail C. Lay et al.   Frontiers in Endocrinology

FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway

(2017) Wen Li et al.   ENDOCRINOLOGY

Atrasentan for the treatment of diabetic nephropathy

(2017) Jesus Egido et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

FOXO transcription factors at the interface of metabolism and cancer

(2017) Wolfgang Link et al.   INTERNATIONAL JOURNAL OF CANCER

TheFOXO1Gene-Obesity Interaction Increases the Risk of Type 2 Diabetes Mellitus in a Chinese Han Population

(2017) Lilin Gong et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

FOXO Transcriptional Factors and Long-Term Living

(2017) Ghulam Murtaza et al.   Oxidative Medicine and Cellular Longevity

SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy

(2017) Yanyan Zhao et al.   Scientific Reports

Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy

(2017) Haoran Dai et al.   Journal of Diabetes Research

Overexpression of FOXO1 ameliorates the podocyte epithelial–mesenchymal transition induced by high glucose in vitro and in vivo

(2016) Mengmeng Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of overexpressing FoxO1 on apoptosis in glomeruli of diabetic mice and in podocytes cultured in high glucose medium

(2016) Wen Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of resveratrol and rosuvastatin on experimental diabetic nephropathy in rats

(2016) Mohamed M.A. Hussein et al.   BIOMEDICINE & PHARMACOTHERAPY

Puerarin, isolated from Pueraria lobata (Willd.), protects against diabetic nephropathy by attenuating oxidative stress

(2016) Xiaohui Xu et al.   GENE

High Glucose Impairs Insulin Signaling in the Glomerulus: An In Vitro and Ex Vivo Approach

(2016) Elias N. Katsoulieris et al.   PLoS One

Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms

(2016) Luigi Gnudi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effects of FoxO1 on podocyte injury in diabetic rats

(2015) Feng Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lentiviral Vector-Mediated FoxO1 Overexpression Inhibits Extracellular Matrix Protein Secretion Under High Glucose Conditions in Mesangial Cells

(2015) Feng Guo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

High glucose induces renal tubular epithelial injury via Sirt1/NF-kappaB/microR-29/Keap1 signal pathway

(2015) Ling Zhou et al.   Journal of Translational Medicine

Activation of FoxO1/ PGC-1α prevents mitochondrial dysfunction and ameliorates mesangial cell injury in diabetic rats

(2015) Lina Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Diabetic kidney disease

(2015) Merlin C. Thomas et al.   Nature Reviews Disease Primers

New Insights Into Molecular Mechanisms of Diabetic Kidney Disease

(2014) Shawn S. Badal et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Clinical Challenges in Diagnosis and Management of Diabetic Kidney Disease

(2014) Robert C. Stanton   AMERICAN JOURNAL OF KIDNEY DISEASES

High Glucose Forces a Positive Feedback Loop Connecting Akt Kinase and FoxO1 Transcription Factor to Activate mTORC1 Kinase for Mesangial Cell Hypertrophy and Matrix Protein Expression

(2014) Falguni Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effect of FoxO1 on the proliferation of rat mesangial cells under high glucose conditions

(2014) F. Liu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Renal Protective Effect of Sirtuin 1

(2014) Yi-jun Dong et al.   Journal of Diabetes Research

Glomerular Endothelial Surface Layer Acts as a Barrier against Albumin Filtration

(2013) Martijn J.C. Dane et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay

(2013) Loredana Fiorentino et al.   EMBO Molecular Medicine

FOXO1 Competes with Carbohydrate Response Element-binding Protein (ChREBP) and Inhibits Thioredoxin-interacting Protein (TXNIP) Transcription in Pancreatic Beta Cells

(2013) Carly Kibbe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical implications of pathologic diagnosis and classification for diabetic nephropathy

(2012) Se Won Oh et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Mesangial cell biology

(2012) Hanna E. Abboud   EXPERIMENTAL CELL RESEARCH

The pathogenic role of the renal proximal tubular cell in diabetic nephropathy

(2012) S. C. W. Tang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

CNK1 and other scaffolds for Akt/FoxO signaling

(2011) Rafael D. Fritz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of FOXO protein stability via ubiquitination and proteasome degradation

(2011) Haojie Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

FoxO1, the transcriptional chief of staff of energy metabolism

(2011) Stavroula Kousteni   BONE

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function

(2010) Gavin I. Welsh et al.   Cell Metabolism

Uncoupling of Acetylation from Phosphorylation Regulates FoxO1 Function Independent of Its Subcellular Localization

(2010) Li Qiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathologic Classification of Diabetic Nephropathy

(2010) T. W. C. Tervaert et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Diabetic nephropathy—challenges in pathologic classification

(2010) Paola Fioretto et al.   Nature Reviews Nephrology

Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid-Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin

(2009) X.-N. Li et al.   DIABETES

MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability

(2009) R. M. Densham et al.   MOLECULAR AND CELLULAR BIOLOGY

Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

(2008) Xiaocheng C. Dong et al.   Cell Metabolism

Development of the renal glomerulus: good neighbors and good fences

(2008) S. E. Quaggin et al.   DEVELOPMENT

Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death

(2008) T. Tejada et al.   KIDNEY INTERNATIONAL

FOXO animal models reveal a variety of diverse roles for FOXO transcription factors

(2008) K C Arden   ONCOGENE

Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification

(2008) Michael M. Brent et al.   STRUCTURE