High Glucose Impairs Insulin Signaling in the Glomerulus: An In Vitro and Ex Vivo Approach

A new oxovanadium complex enhances renal function by improving insulin signaling pathway in diabetic mice

(2014) Y. Liu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Metformin Attenuates Palmitate-Induced Endoplasmic Reticulum Stress, Serine Phosphorylation of IRS-1 and Apoptosis in Rat Insulinoma Cells

(2014) Laura Simon-Szabó et al.   PLoS One

Expression of SHP-1 induced by hyperglycemia prevents insulin actions in podocytes

(2013) Nicolas Drapeau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose-induced gradual phenotypic modulation of cultured human glomerular epithelial cells may be independent of Wilms’ tumor 1 (WT1)

(2013) Nikolaos E Tsotakos et al.   BMC CELL BIOLOGY

Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38  MAPK During Insulin Resistance

(2013) Y. Qi et al.   DIABETES

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice

(2012) M. Y. Kim et al.   DIABETOLOGIA

Altered expression and localization of insulin receptor in proximal tubule cells from human and rat diabetic kidney

(2012) Rodrigo Gatica et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity

(2011) Akira Mima et al.   KIDNEY INTERNATIONAL

Concentration-dependent Dual Effects of Hydrogen Peroxide on Insulin Signal Transduction in H4IIEC Hepatocytes

(2011) Satoshi Iwakami et al.   PLoS One

Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function

(2010) Gavin I. Welsh et al.   Cell Metabolism

Differences in endoplasmic reticulum stress signalling kinetics determine cell survival outcome through activation of MKP-1

(2010) Bin Li et al.   CELLULAR SIGNALLING

IGF-I Activation of the AKT Pathway Is Impaired in Visceral But Not Subcutaneous Preadipocytes from Obese Subjects

(2010) Kelly Cleveland-Donovan et al.   ENDOCRINOLOGY

Lipotoxicity in renal proximal tubular cells: Relationship between endoplasmic reticulum stress and oxidative stress pathways

(2010) Elias Katsoulieris et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hyperglycemia and mechanical stress: Targeting the renal podocyte

(2009) Barbara Lewko et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis

(2009) S. Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

Aldosterone Induces Apoptosis in Rat Podocytes: Role of PI3-K/Akt and p38MAPK Signaling Pathways

(2009) Cheng Chen et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

RAGE, glomerulosclerosis and proteinuria: Roles in podocytes and endothelial cells

(2009) Vivette D’Agati et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

(2008) Xiaocheng C. Dong et al.   Cell Metabolism

Renal Activity of Akt Kinase in Obese Zucker Rats

(2008) Jana Ždychová et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Diabetic Nephropathy: Mechanisms of Renal Disease Progression

(2008) Yashpal S. Kanwar et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death

(2008) T. Tejada et al.   KIDNEY INTERNATIONAL

The pathogenesis of diabetic nephropathy

(2008) Suma Dronavalli et al.   Nature clinical practice. Endocrinology & metabolism