Risk Compounds, Preclinical Toxicity Evaluation, and Potential Mechanisms of Chinese Materia Medica–Induced Cardiotoxicity
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Risk Compounds, Preclinical Toxicity Evaluation, and Potential Mechanisms of Chinese Materia Medica–Induced Cardiotoxicity
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-03-30
DOI
10.3389/fphar.2021.578796
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Aconitine induces cardiotoxicity through regulation of calcium signaling pathway in zebrafish embryos and in H9c2 cells
- (2020) Mengting Li et al. JOURNAL OF APPLIED TOXICOLOGY
- Classification, hepatotoxic mechanisms, and targets of the risk ingredients in traditional Chinese medicine-induced liver injury
- (2020) Xiaoqi Pan et al. TOXICOLOGY LETTERS
- Notch1-mediated histone demethylation of HCN4 contributes to aconitine-induced ventricular myocardial dysrhythmia
- (2020) Wei Zhou et al. TOXICOLOGY LETTERS
- Research Progress on Main Symptoms of Novel Coronavirus Pneumonia Improved by Traditional Chinese Medicine
- (2020) Chuan-hong Luo et al. Frontiers in Pharmacology
- An integrated characterization of contractile, electrophysiological, and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes
- (2019) Ruiying Wang et al. Stem Cell Research & Therapy
- MicroRNA expression, targeting, release dynamics and early-warning biomarkers in acute cardiotoxicity induced by triptolide in rats
- (2019) Shu-Rong Wang et al. BIOMEDICINE & PHARMACOTHERAPY
- Arsenic trioxide blocked proliferation and cardiomyocyte differentiation of human induced pluripotent stem cells: Implication in cardiac developmental toxicity
- (2019) Zhengyi Bao et al. TOXICOLOGY LETTERS
- Circadian sensitivity to the cardiac glycoside oleandrin is associated with diurnal intestinal P-glycoprotein expression
- (2019) Cui Zhou et al. BIOCHEMICAL PHARMACOLOGY
- Aconitine induces cardiomyocyte damage by mitigating BNIP3‐dependent mitophagy and the TNFα‐NLRP3 signalling axis
- (2019) Fu Peng et al. CELL PROLIFERATION
- Integrated metabolomics and network toxicology to reveal molecular mechanism of celastrol induced cardiotoxicity
- (2019) Chuanxin Liu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- UPLC-HDMS-based on serum metabolomics reveals the toxicity of arecae semen
- (2019) Qinghua Lin et al. JOURNAL OF ETHNOPHARMACOLOGY
- Triptolide dysregulates glucose uptake via inhibition of IKKβ-NF-κB pathway by p53 activation in cardiomyocytes
- (2019) Yue Xi et al. TOXICOLOGY LETTERS
- PGC-1: The Energetic Regulator in Cardiac Metabolism
- (2018) Wencheng Di et al. CURRENT ISSUES IN MOLECULAR BIOLOGY
- Regulation of autophagy factors by oxidative stress and cardiac enzymes imbalance during arsenic or/and copper induced cardiotoxicity in Gallus gallus
- (2018) Siwen Li et al. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
- Centipedes subdue giant prey by blocking KCNQ channels
- (2018) Lei Luo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Triptolide induces p53-dependent cardiotoxicity through mitochondrial membrane permeabilization in cardiomyocytes
- (2018) Yue Xi et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- L-ascorbic acid and α-tocopherol attenuate arsenic trioxide-induced toxicity in H9c2 cardiomyocytes by the activation of Nrf2 and Bcl2 transcription factors
- (2018) Radhakrishnan Chandraprabha Vineetha et al. TOXICOLOGY MECHANISMS AND METHODS
- Scorpion toxins to unravel the conundrum of ion channel structure and functioning
- (2018) Ernesto Ortiz et al. TOXICON
- L-ascorbic acid and α-tocopherol attenuate arsenic trioxide-induced toxicity in H9c2 cardiomyocytes by the activation of Nrf2 and Bcl2 transcription factors
- (2018) Radhakrishnan Chandraprabha Vineetha et al. TOXICOLOGY MECHANISMS AND METHODS
- Natriuretic Peptides in Heart Failure
- (2018) Alan S. Maisel et al. Heart Failure Clinics
- Salvianolic Acid A Ameliorates Arsenic Trioxide-Induced Cardiotoxicity Through Decreasing Cardiac Mitochondrial Injury and Promotes Its Anticancer Activity
- (2018) Jing-yi Zhang et al. Frontiers in Pharmacology
- Störungen des Kalziumhaushalts
- (2018) Markus Müller ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE
- Hybrids of arenobufagin and benzoisoselenazol reducing the cardiotoxicity of arenobufagin
- (2018) Wen Hou et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Removal of hERG potassium channel affinity through introduction of an oxygen atom: Molecular insights from structure-activity relationships of strychnine and its analogs
- (2018) Chunhua Yuan et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Bradycardia and Hypotension from Improper Use of Aconite Root: A Case Report and Brief Review
- (2018) Pei-Ying Chou et al. Complementary Medicine Research
- MicroRNAs in the diagnosis and prevention of drug-induced cardiotoxicity
- (2018) Mikuláš Skála et al. ARCHIVES OF TOXICOLOGY
- Arsenic-induced cardiotoxicity correlates with mitochondrial damage and trace elements imbalance in broiler chickens
- (2018) Siwen Li et al. POULTRY SCIENCE
- Sweroside Alleviated Aconitine-Induced Cardiac Toxicity in H9c2 Cardiomyoblast Cell Line
- (2018) Li-Qun Ma et al. Frontiers in Pharmacology
- Assessment of arsenic trioxide in the heart of Gallus gallus: alterations of oxidative damage parameters, inflammatory cytokines, and cardiac enzymes
- (2017) Si-Wen Li et al. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
- Cardiotoxicity evaluation of nine alkaloids from Rhizoma Coptis
- (2017) MY Zhang et al. HUMAN & EXPERIMENTAL TOXICOLOGY
- Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF-κB pathway
- (2017) Kewei Ren et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Hydroalcoholic extract from Nerium oleander L. (Apocynaceae) elicits arrhythmogenic activity
- (2017) Ana Flávia Machado Botelho et al. JOURNAL OF ETHNOPHARMACOLOGY
- Fibroblast Activation Protein α Activated Tripeptide Bufadienolide Antitumor Prodrug with Reduced Cardiotoxicity
- (2017) Li-Juan Deng et al. JOURNAL OF MEDICINAL CHEMISTRY
- Assessment of in vitro cardiotoxicity of extract fractions and diterpene alkaloids from Aconitum leucostomum Worosch: A short communication
- (2017) Jihong Nie et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- An integrative investigation of the toxicity of Aconiti kusnezoffii radix and the attenuation effect of its processed drug using a UHPLC-Q-TOF based rat serum and urine metabolomics strategy
- (2017) Zhenyu Sui et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial?
- (2017) Xingjuan Shi et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Evaluation of the Cardiotoxicity of Evodiamine In Vitro and In Vivo
- (2017) Weifeng Yang et al. MOLECULES
- Diterpene Lipo-Alkaloids with Selective Activities on Cardiac K+ Channels
- (2017) Tivadar Kiss et al. PLANTA MEDICA
- Attenuation of arsenic trioxide induced cardiotoxicity through flaxseed oil in experimental rats
- (2017) Mathews V. Varghese et al. REDOX REPORT
- Mechanism of As2O3-Induced Action Potential Prolongation and Using hiPS-CMs to Evaluate the Rescue Efficacy of Drugs With Different Rescue Mechanism
- (2017) Meng Yan et al. TOXICOLOGICAL SCIENCES
- Calcium homeostasis and endoplasmic reticulum stress are involved in Salvianolic acid B-offered protection against cardiac toxicity of arsenic trioxide
- (2017) Jing-Yi Zhang et al. Oncotarget
- Arsenic trioxide and angiotensin II have inhibitory effects on HERG protein expression: Evidence for the role of PML SUMOylation
- (2017) Yu Liu et al. Oncotarget
- The Structure and Function of the Na,K-ATPase Isoforms in Health and Disease
- (2017) Michael V. Clausen et al. Frontiers in Physiology
- L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes
- (2017) Jianjun Wu et al. PLoS One
- Molecular mechanisms of ROS production and oxidative stress in diabetes
- (2016) P. Newsholme et al. BIOCHEMICAL JOURNAL
- Grape seed and skin extract protects against arsenic trioxide induced oxidative stress in rat heart
- (2016) Ichraf Sfaxi et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Metabolomics and its application to the evaluation of the efficacy and toxicity of traditional Chinese herb medicines
- (2016) Jian Shi et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Validation of biomarkers in cardiotoxicity induced by Periplocin on neonatal rat cardiomyocytes using UPLC-Q-TOF/MS combined with a support vector machine
- (2016) Aizhu Li et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Inhibition of glycogen synthase kinase 3beta ameliorates triptolide-induced acute cardiac injury by desensitizing mitochondrial permeability transition
- (2016) Wenwen Wang et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- TXNIP/TRX/NF-κB and MAPK/NF-κB pathways involved in the cardiotoxicity induced by Venenum Bufonis in rats
- (2016) Qi-rui Bi et al. Scientific Reports
- Arsenic trioxide triggered calcium homeostasis imbalance and induced endoplasmic reticulum stress-mediated apoptosis in adult rat ventricular myocytes
- (2016) Jing-yi Zhang et al. Toxicology Research
- Metabolomics reveals the mechanisms for the cardiotoxicity of Pinelliae Rhizoma and the toxicity-reducing effect of processing
- (2016) Tao Su et al. Scientific Reports
- Cardiotoxicity screening: a review of rapid-throughput in vitro approaches
- (2015) Xichun Li et al. ARCHIVES OF TOXICOLOGY
- Inflammatory Biomarkers and Therapeutic Targets in Heart Failure
- (2015) Lampros Papadimitriou et al. CURRENT MEDICINAL CHEMISTRY
- Phloretin ameliorates arsenic trioxide induced mitochondrial dysfunction in H9c2 cardiomyoblasts mediated via alterations in membrane permeability and ETC complexes
- (2015) Vadavanath Prabhakaran Vineetha et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Hypaconitine-induced QT prolongation mediated through inhibition of KCNH2 (hERG) potassium channels in conscious dogs
- (2015) Shuilin Xie et al. JOURNAL OF ETHNOPHARMACOLOGY
- Screening, Verification, and Optimization of Biomarkers for Early Prediction of Cardiotoxicity Based on Metabolomics
- (2015) Yubo Li et al. JOURNAL OF PROTEOME RESEARCH
- Roles of oxidative stress and the ERK1/2, PTEN and p70S6K signaling pathways in arsenite-induced autophagy
- (2015) Ya-Chun Huang et al. TOXICOLOGY LETTERS
- Autophagy plays an important role in triptolide-induced apoptosis in cardiomyocytes
- (2015) Jie Zhou et al. TOXICOLOGY LETTERS
- Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency
- (2015) Baoxi Li et al. Drug Design Development and Therapy
- A distinct three-helix centipede toxin SSD609 inhibits I ks channels by interacting with the KCNE1 auxiliary subunit
- (2015) Peibei Sun et al. Scientific Reports
- Study of the Cardiotoxicity of Venenum Bufonis in Rats using an 1H NMR-Based Metabolomics Approach
- (2015) Ge Dong et al. PLoS One
- Up-regulation of miR-21 and miR-23a Contributes to As2O3-induced hERG Channel Deficiency
- (2014) Xin Zhao et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Berberine Induces hERG Channel Deficiency through Trafficking Inhibition
- (2014) Kaiping Zhang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias
- (2014) Dobromir Dobrev et al. CIRCULATION RESEARCH
- Triptolide: Progress on research in pharmacodynamics and toxicology
- (2014) Xiao-Jiaoyang Li et al. JOURNAL OF ETHNOPHARMACOLOGY
- The integrated pharmacokinetics of major rhodojaponins correlates with the cardiotoxicity after oral administration of Rhododendri Mollis Flos extract in rats
- (2014) Lei-Chi Dong et al. JOURNAL OF ETHNOPHARMACOLOGY
- A review on phytochemistry, pharmacology and toxicology studies ofAconitum
- (2014) Eric Nyirimigabo et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Cellular mechanisms and physiological consequences of redox-dependent signalling
- (2014) Kira M. Holmström et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Arsenic Trioxide and Resveratrol Show Synergistic Anti-Leukemia Activity and Neutralized Cardiotoxicity
- (2014) Yuhua Fan et al. PLoS One
- Activation of the ubiquitin–proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis
- (2014) Mayumi Watanabe et al. TOXICOLOGY
- Aconitine-induced Ca2+ overload causes arrhythmia and triggers apoptosis through p38 MAPK signaling pathway in rats
- (2014) Gui-bo Sun et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Coactivation of the PI3K/Akt and ERK signaling pathways in PCB153-induced NF-κB activation and caspase inhibition
- (2014) Changjiang Liu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Triptolide-induced oxidative stress involved with Nrf2 contribute to cardiomyocyte apoptosis through mitochondrial dependent pathways
- (2014) Jie Zhou et al. TOXICOLOGY LETTERS
- Cardiotoxic Changes of Colchicine Intoxication in Rats: Electrocardiographic, Histopathological and Blood Chemical Analysis
- (2014) Ryota Tochinai et al. Journal of Toxicologic Pathology
- The Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity
- (2013) Weiqian Zhang et al. Evidence-based Complementary and Alternative Medicine
- Spatial correlation of action potential duration and diastolic dysfunction in transgenic and drug-induced LQT2 rabbits
- (2013) Katja E. Odening et al. HEART RHYTHM
- Arrhythmogenesis Toxicity of Aconitine Is Related to Intracellular Ca2+ Signals
- (2013) Yu-hong Zhou et al. International Journal of Medical Sciences
- Globular Adiponectin Attenuates Myocardial Ischemia/Reperfusion Injury by Upregulating Endoplasmic Reticulum Ca2+-ATPase Activity and Inhibiting Endoplasmic Reticulum Stress
- (2013) Jia Guo et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- General toxicity of Pinellia ternata (Thunb.) Berit. in rat: A metabonomic method for profiling of serum metabolic changes
- (2013) Zhi-Hao Zhang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Myocardial lipidomics profiling delineate the toxicity of traditional Chinese medicine Aconiti Lateralis radix praeparata
- (2013) Yamei Cai et al. JOURNAL OF ETHNOPHARMACOLOGY
- Provocation of an Autoimmune Response to Cardiac Voltage-Gated Sodium Channel NaV1.5 Induces Cardiac Conduction Defects in Rats
- (2013) Sevil Korkmaz et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Scorpion venom components that affect ion-channels function
- (2013) V. Quintero-Hernández et al. TOXICON
- Arsenic trioxide-induced hERG K+ channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression
- (2012) Ying Zhang et al. BIOCHEMICAL PHARMACOLOGY
- Carnitine and Acylcarnitines
- (2012) Stephanie E. Reuter et al. CLINICAL PHARMACOKINETICS
- Upregulation of microRNA-1 and microRNA-133 contributes to arsenic-induced cardiac electrical remodeling
- (2012) Hongli Shan et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Effect of hypaconitine combined with liquiritin on the expression of calmodulin and connexin43 in rat cardiac musclein vivo
- (2012) Mingjing Yi et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Cardioprotective effect of salvianolic acid B against arsenic trioxide-induced injury in cardiac H9c2 cells via the PI3K/Akt signal pathway
- (2012) Min Wang et al. TOXICOLOGY LETTERS
- Development of High Content Imaging Methods for Cell Death Detection in Human Pluripotent Stem Cell-Derived Cardiomyocytes
- (2012) Maxime Mioulane et al. Journal of Cardiovascular Translational Research
- L-type Calcium Current (ICa,L) and Inward Rectifier Potassium Current (IK1) are Involved in QT Prolongation Induced by Arsenic Trioxide in Rat
- (2011) Xichuang Chen et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Ca2+ store depletion and endoplasmic reticulum stress are involved in P2X7 receptor-mediated neurotoxicity in differentiated NG108-15 cells
- (2011) Chia-Chia Chao et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Metabolomics Study on the Toxicity of Aconite Root and Its Processed Products Using Ultraperformance Liquid-Chromatography/Electrospray-Ionization Synapt High-Definition Mass Spectrometry Coupled with Pattern Recognition Approach and Ingenuity Pathways Analysis
- (2011) Xijun Wang et al. JOURNAL OF PROTEOME RESEARCH
- XPB, a subunit of TFIIH, is a target of the natural product triptolide
- (2011) Denis V Titov et al. Nature Chemical Biology
- Biology of Endoplasmic Reticulum Stress in the Heart
- (2010) Jody Groenendyk et al. CIRCULATION RESEARCH
- Aconitine intoxication mimicking acute myocardial infarction
- (2010) Chun-Chi Lin et al. HUMAN & EXPERIMENTAL TOXICOLOGY
- Aconitine blocks HERG and Kv1.5 potassium channels
- (2010) Yifu Li et al. JOURNAL OF ETHNOPHARMACOLOGY
- Identification of the toxic constituents in Rhizoma Coptidis
- (2010) Bing-Liang Ma et al. JOURNAL OF ETHNOPHARMACOLOGY
- Post-conditioning protects cardiomyocytes from apoptosis via PKCε-interacting with calcium-sensing receptors to inhibit endo(sarco)plasmic reticulum–mitochondria crosstalk
- (2010) Shiyun Dong et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine
- (2010) D. An et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Primary Endothelial Damage Is the Mechanism of Cardiotoxicity of Tubulin-Binding Drugs
- (2010) Igor Mikaelian et al. TOXICOLOGICAL SCIENCES
- Arsenic trioxide induces the apoptosis in bone marrow mesenchymal stem cells by intracellular calcium signal and caspase-3 pathways
- (2010) Ben-Zhi Cai et al. TOXICOLOGY LETTERS
- Metabolomic analysis of biofluids from rats treated with Aconitum alkaloids using nuclear magnetic resonance and gas chromatography/time-of-flight mass spectrometry
- (2009) Bo Sun et al. ANALYTICAL BIOCHEMISTRY
- Ca2+-Calmodulin Increases RyR2 Open Probability yet Reduces Ryanoid Association with RyR2
- (2009) Charalambos Sigalas et al. BIOPHYSICAL JOURNAL
- Ca2+-calmodulin can activate and inactivate cardiac ryanodine receptors
- (2009) C Sigalas et al. BRITISH JOURNAL OF PHARMACOLOGY
- Arsenic Exposure and Cardiovascular Disorders: An Overview
- (2009) Pitchai Balakumar et al. Cardiovascular Toxicology
- From the Ryanodine Receptor to Cardiac Arrhythmias
- (2009) D. A. Eisner et al. CIRCULATION JOURNAL
- Sudden death associated with intravenous injection of toad extract
- (2009) Chris Kostakis et al. FORENSIC SCIENCE INTERNATIONAL
- Crosstalk signaling between mitochondrial Ca2+ and ROS
- (2009) Robert et al. Frontiers in Bioscience-Landmark
- In vitro cardiotoxicity and mechanism of action of the Egyptian green toad Bufo viridis skin secretions
- (2009) Mohamed A. Abdel-Rahman et al. TOXICOLOGY IN VITRO
- Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid
- (2008) Prasenjit Manna et al. ARCHIVES OF TOXICOLOGY
- Sarcoplasmic reticulum Ca2+ release channel ryanodine receptor (RyR2) plays a crucial role in aconitine-induced arrhythmias
- (2008) Min Fu et al. BIOCHEMICAL PHARMACOLOGY
- The regulation of the cardiac potassium channel (HERG) by caveolin-1
- (2008) Jijin Lin et al. Biochemistry and Cell Biology
- Metabonomic study on the toxicity of Hei-Shun-Pian, the processed lateral root of Aconitum carmichaelii Debx. (Ranunculaceae)
- (2008) Ling Li et al. JOURNAL OF ETHNOPHARMACOLOGY
- Time-Dependent Block of Ultrarapid-Delayed Rectifier K+ Currents by Aconitine, a Potent Cardiotoxin, in Heart-Derived H9c2 Myoblasts and in Neonatal Rat Ventricular Myocytes
- (2008) Ya-Jean Wang et al. TOXICOLOGICAL SCIENCES
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started