An integrated characterization of contractile, electrophysiological, and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes

Cardioprotective effects of total flavonoids from Jinhe Yangxin prescription by activating the PI3K/Akt signaling pathway in myocardial ischemia injury

(2018) Yangang Cheng et al.   BIOMEDICINE & PHARMACOTHERAPY

Protective Effect of Ellagic Acid Against Sodium Arsenite-Induced Cardio- and Hematotoxicity in Rats

(2018) Mehdi Goudarzi et al.   Cardiovascular Toxicology

MiR-592 Promotes Gastric Cancer Proliferation, Migration, and Invasion Through the PI3K/AKT and MAPK/ERK Signaling Pathways by Targeting Spry2

(2018) Yu He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Moving beyond the comprehensive in vitro proarrhythmia assay: Use of human-induced pluripotent stem cell-derived cardiomyocytes to assess contractile effects associated with drug-induced structural cardiotoxicity

(2018) Xi Yang et al.   JOURNAL OF APPLIED TOXICOLOGY

Propofol elicits autophagy via endoplasmic reticulum stress and calcium exchange in C2C12 myoblast cell line

(2018) Xi Chen et al.   PLoS One

VCAM1-targeted RNA interference inhibits the proliferation of human oral squamous carcinoma HN12 cells

(2018) Legang Sun et al.   Oncology Letters

Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer

(2018) Yuxiu Huang et al.   Oncology Letters

MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2

(2018) Lisha Zhao et al.   Redox Biology

Low-dose combined exposure of nanoparticles and heavy metal compared with PM2.5 in human myocardial AC16 cells

(2017) Lin Feng et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

An impedance-based approach using human iPSC-derived cardiomyocytes significantly improves in vitro prediction of in vivo cardiotox liabilities

(2017) Bryan Koci et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes

(2017) Qi Zhao et al.   Stem Cell Research & Therapy

A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes

(2017) Hiroyuki Ando et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes

(2017) Jing Zhao et al.   PLoS One

Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1

(2017) K. M. Lawrence et al.   Scientific Reports

Evolution of strategies to improve preclinical cardiac safety testing

(2016) Gary Gintant et al.   NATURE REVIEWS DRUG DISCOVERY

Safety pharmacology studies using EFP and impedance

(2016) Alison Obergrussberger et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

(2016) Thomas Colatsky et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates

(2015) Sebastian Polak et al.   AAPS Journal

Matrine pretreatment improves cardiac function in rats with diabetic cardiomyopathy via suppressing ROS/TLR-4 signaling pathway

(2015) Zhong-wei Liu et al.   ACTA PHARMACOLOGICA SINICA

Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury

(2015) M J Cross et al.   BRITISH JOURNAL OF PHARMACOLOGY

High-throughput cardiac safety evaluation and multi-parameter arrhythmia profiling of cardiomyocytes using microelectrode arrays

(2015) Kristin H. Gilchrist et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oral sophocarpine protects rat heart against pressure overload-induced cardiac fibrosis

(2014) Jun Li et al.   PHARMACEUTICAL BIOLOGY

Developmental toxicity and neurotoxicity of two matrine-type alkaloids, matrine and sophocarpine, in zebrafish (Danio rerio) embryos/larvae

(2014) Zhao-Guang Lu et al.   REPRODUCTIVE TOXICOLOGY

Depolarization of Mitochondria in Endothelial Cells Promotes Cerebral Artery Vasodilation by Activation of Nitric Oxide Synthase

(2013) Prasad V.G. Katakam et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Human induced pluripotent stem cells and their use in drug discovery for toxicity testing

(2013) Clay W Scott et al.   TOXICOLOGY LETTERS

Arsenic trioxide-induced hERG K+ channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression

(2012) Ying Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Matrine Inhibits Pacing Induced Atrial Fibrillation by Modulating IKM3 and ICa-L

(2012) Yuhong Zhou et al.   International Journal of Biological Sciences

Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment

(2011) Yama A Abassi et al.   BRITISH JOURNAL OF PHARMACOLOGY

The negative inotropic effects of homocysteine were prevented by matrine via the regulating intracellular calcium level

(2011) Benzhi Cai et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review

(2011) Carl-Fredrik Mandenius et al.   JOURNAL OF APPLIED TOXICOLOGY

Minimal Peroxide Exposure of Neuronal Cells Induces Multifaceted Adaptive Responses

(2010) Wayne Chadwick et al.   PLoS One

Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors

(2009) Yi-Fan Li et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Cerebrovascular Responses to Insulin in Rats

(2009) Prasad Venkateswera Gurunath Katakam et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes

(2009) Stefan R. Braam et al.   Stem Cell Research

Inotropic Effects and Mechanisms of Matrine, a Main Alkaloid from Sophora flavescens AIT

(2008) Yuhong Zhou et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN