A functional perspective on phenotypic heterogeneity in microorganisms

Phenotypic heterogeneity in metabolic traits among single cells of a rare bacterial species in its natural environment quantified with a combination of flow cell sorting and NanoSIMS

(2015) Matthias Zimmermann et al.   Frontiers in Microbiology

In situvisualization of newly synthesized proteins in environmental microbes using amino acid tagging and click chemistry

(2014) Roland Hatzenpichler et al.   ENVIRONMENTAL MICROBIOLOGY

Quantifying the effects of the division of labor in metabolic pathways

(2014) Emily Harvey et al.   JOURNAL OF THEORETICAL BIOLOGY

Model selection for microbial nutrient uptake using a cost-benefit approach

(2014) J. Müller et al.   MATHEMATICAL BIOSCIENCES

Bacterial Genome Instability

(2014) E. Darmon et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Phenotypic bistability in Escherichia coli's central carbon metabolism

(2014) O. Kotte et al.   Molecular Systems Biology

Syntrophic exchange in synthetic microbial communities

(2014) M. T. Mee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bet-hedging during bacterial diauxic shift

(2014) A. Solopova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lost in Transition: Start-Up of Glycolysis Yields Subpopulations of Nongrowing Cells

(2014) J. H. van Heerden et al.   SCIENCE

Different Levels of Catabolite Repression Optimize Growth in Stable and Variable Environments

(2014) Aaron M. New et al.   PLOS BIOLOGY

Bistable Expression of Virulence Genes in Salmonella Leads to the Formation of an Antibiotic-Tolerant Subpopulation

(2014) Markus Arnoldini et al.   PLOS BIOLOGY

The Effect of Cell Growth Phase on the Regulatory Cross-Talk between Flagellar and Spi1 Virulence Gene Expression

(2014) Chakib Mouslim et al.   PLoS Pathogens

Adaptability of non-genetic diversity in bacterial chemotaxis

(2014) Nicholas W Frankel et al.   eLife

Regulation of Noise in Gene Expression

(2013) Alvaro Sanchez et al.   Annual Review of Biophysics

Analysis of fluorescent reporters indicates heterogeneity in glucose uptake and utilization in clonal bacterial populations

(2013) Nela Nikolic et al.   BMC MICROBIOLOGY

Single-cell phenomics reveals intra-species variation of phenotypic noise in yeast

(2013) Gaël Yvert et al.   BMC Systems Biology

A Super-Assembly of Whi3 Encodes Memory of Deceptive Encounters by Single Cells during Yeast Courtship

(2013) Fabrice Caudron et al.   CELL

Phenotypic heterogeneity is a selected trait in natural yeast populations subject to environmental stress

(2013) Sara L. Holland et al.   ENVIRONMENTAL MICROBIOLOGY

The private life of environmental bacteria: pollutant biodegradation at the single cell level

(2013) Pablo Iván Nikel et al.   ENVIRONMENTAL MICROBIOLOGY

Fitness and stability of obligate cross-feeding interactions that emerge upon gene loss in bacteria

(2013) Samay Pande et al.   ISME Journal

Measuring carbon and N2fixation in field populations of colonial and free-living unicellular cyanobacteria using nanometer-scale secondary ion mass spectrometry1

(2013) Rachel A. Foster et al.   JOURNAL OF PHYCOLOGY

Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability

(2013) S. Fehrmann et al.   Molecular Systems Biology

Memory and modularity in cell-fate decision making

(2013) Thomas M. Norman et al.   NATURE

Stabilization of cooperative virulence by the expression of an avirulent phenotype

(2013) Médéric Diard et al.   NATURE

Going local: technologies for exploring bacterial microenvironments

(2013) Aimee K. Wessel et al.   NATURE REVIEWS MICROBIOLOGY

Resolution of Conflicting Signals at the Single-Cell Level in the Regulation of Cyanobacterial Photosynthesis and Nitrogen Fixation

(2013) Wiebke Mohr et al.   PLoS One

Heterogeneity in protein expression induces metabolic variability in a modeledEscherichia colipopulation

(2013) Piyush Labhsetwar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Persistence of Antibiotic-Stressed Mycobacteria

(2013) Y. Wakamoto et al.   SCIENCE

Functional Roles of Pulsing in Genetic Circuits

(2013) J. H. Levine et al.   SCIENCE

Microbial individuality in the natural environment

(2012) M Ackermann   ISME Journal

Metabolic specialization and the assembly of microbial communities

(2012) David R Johnson et al.   ISME Journal

Stochasticity of TOL plasmid catabolic promoters sets a bimodal expression regime inPseudomonas putidamt-2 exposed tom-xylene

(2012) Rafael Silva-Rocha et al.   MOLECULAR MICROBIOLOGY

Marine Microbes See a Sea of Gradients

(2012) R. Stocker   SCIENCE

Cellular cooperation: insights from microbes

(2012) Hasan Celiker et al.   TRENDS IN CELL BIOLOGY

Bet Hedging in Yeast by Heterogeneous, Age-Correlated Expression of a Stress Protectant

(2012) Sasha F. Levy et al.   PLOS BIOLOGY

A Genome-Wide Analysis of Promoter-Mediated Phenotypic Noise in Escherichia coli

(2012) Olin K. Silander et al.   PLoS Genetics

A computational exploration of bacterial metabolic diversity identifying metabolic interactions and growth-efficient strain communities

(2011) Eleftheria Tzamali et al.   BMC Systems Biology

Cellular Decision Making and Biological Noise: From Microbes to Mammals

(2011) Gábor Balázsi et al.   CELL

Macromotives and microbehaviors: the social dimension of bacterial phenotypic variability

(2011) Peter Reuven et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Pole Age Affects Cell Size and the Timing of Cell Division in Methylobacterium extorquens AM1

(2011) T. Bergmiller et al.   JOURNAL OF BACTERIOLOGY

Synthetic Escherichia coli consortia engineered for syntrophy demonstrate enhanced biomass productivity

(2011) Hans C. Bernstein et al.   JOURNAL OF BIOTECHNOLOGY

Temporal and spatial oscillations in bacteria

(2011) Peter Lenz et al.   NATURE REVIEWS MICROBIOLOGY

Origins of regulated cell-to-cell variability

(2011) Berend Snijder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response

(2011) M. K. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of gene expression noise on organismal fitness and the efficacy of natural selection

(2011) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Varying virulence: epigenetic control of expression noise and disease processes

(2011) Kathryn Miller-Jensen et al.   TRENDS IN BIOTECHNOLOGY

A Novel Mechanism of Programmed Cell Death in Bacteria by Toxin–Antitoxin Systems Corrupts Peptidoglycan Synthesis

(2011) Hannes Mutschler et al.   PLOS BIOLOGY

The Cost of Virulence: Retarded Growth of Salmonella Typhimurium Cells Expressing Type III Secretion System 1

(2011) Alexander Sturm et al.   PLoS Pathogens

Cellular Heterogeneity: Do Differences Make a Difference?

(2010) Steven J. Altschuler et al.   CELL

Single cell metabolomics

(2010) Matthias Heinemann et al.   CURRENT OPINION IN BIOTECHNOLOGY

Emergent cooperation in microbial metabolism

(2010) Edwin H Wintermute et al.   Molecular Systems Biology

Non-genetic heterogeneity from stochastic partitioning at cell division

(2010) Dann Huh et al.   NATURE GENETICS

Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence

(2010) Eitan Rotem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Individual histories and selection in heterogeneous populations

(2010) S. Leibler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly heterogeneous activation of the master regulator for sporulation in Bacillus subtilis

(2010) A. Chastanet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

(2010) Y. Taniguchi et al.   SCIENCE

Conflict between Noise and Plasticity in Yeast

(2010) Ben Lehner   PLoS Genetics

Single-Cell Ecophysiology of Microbes as Revealed by Raman Microspectroscopy or Secondary Ion Mass Spectrometry Imaging

(2009) Michael Wagner   Annual Review of Microbiology

Bacterial landlines: contact-dependent signaling in bacterial populations

(2009) Matthew G Blango et al.   CURRENT OPINION IN MICROBIOLOGY

Linking environmental heterogeneity and reproductive success at single-cell resolution

(2009) Mitja NP Remus-Emsermann et al.   ISME Journal

Strategies for cellular decision-making

(2009) Theodore J Perkins et al.   Molecular Systems Biology

Experimental evolution of bet hedging

(2009) Hubertus J. E. Beaumont et al.   NATURE

Population context determines cell-to-cell variability in endocytosis and virus infection

(2009) Berend Snijder et al.   NATURE

Prokaryotic transcriptomics: a new view on regulation, physiology and pathogenicity

(2009) Rotem Sorek et al.   NATURE REVIEWS GENETICS

Using movies to analyse gene circuit dynamics in single cells

(2009) James C. W. Locke et al.   NATURE REVIEWS MICROBIOLOGY

Polarity and Differential Inheritance—Universal Attributes of Life?

(2008) Ian G. Macara et al.   CELL

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Selection to minimise noise in living systems and its implications for the evolution of gene expression

(2008) Ben Lehner   Molecular Systems Biology

Self-destructive cooperation mediated by phenotypic noise

(2008) Martin Ackermann et al.   NATURE

Stochastic switching as a survival strategy in fluctuating environments

(2008) Murat Acar et al.   NATURE GENETICS

Physiological heterogeneity in biofilms

(2008) Philip S. Stewart et al.   NATURE REVIEWS MICROBIOLOGY

Resistance, resilience, and redundancy in microbial communities

(2008) S. D. Allison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single-cell view on the ecophysiology of anaerobic phototrophic bacteria

(2008) N. Musat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait

(2008) Juliet Ansel et al.   PLoS Genetics

A Simple Screen to Identify Promoters Conferring High Levels of Phenotypic Noise

(2008) Nikki E. Freed et al.   PLoS Genetics