Extracellular vesicles secreted by Giardia duodenalis regulate host cell innate immunity via TLR2 and NLRP3 inflammasome signaling pathways

Giardia spp. promote the production of antimicrobial peptides and attenuate disease severity induced by attaching and effacing enteropathogens via the induction of the NLRP3 inflammasome

(2020) Anna Manko-Prykhoda et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK

(2020) Chunfeng Xie et al.   JOURNAL OF HAZARDOUS MATERIALS

Unravelling the proteomic signature of extracellular vesicles released by drug-resistant Leishmania infantum parasites

(2020) Noélie Douanne et al.   PLoS Neglected Tropical Diseases

Peptidylarginine Deiminase Inhibition Abolishes the Production of Large Extracellular Vesicles From Giardia intestinalis, Affecting Host-Pathogen Interactions by Hindering Adhesion to Host Cells

(2020) Bruno Gavinho et al.   Frontiers in Cellular and Infection Microbiology

Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins

(2019) Marianela C. Serradell et al.   Nature Communications

Extracellular vesicles from Echinococcus granulosus larval stage: Isolation, characterization and uptake by dendritic cells

(2019) María Celeste Nicolao et al.   PLoS Neglected Tropical Diseases

Exosomal miRNAs from highly metastatic cells can induce metastasis in non-metastatic cells

(2019) Vahid kia et al.   LIFE SCIENCES

NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways

(2019) Jaye M. Platnich et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Lung cancer-derived extracellular vesicles induced myotube atrophy and adipocyte lipolysis via the extracellular IL-6-mediated STAT3 pathway

(2019) Wenjun Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Caspase‐1 Inflammasome Activity in Patients with Staphylococcus aureus Bacteremia

(2019) Gunlög Rasmussen et al.   MICROBIOLOGY AND IMMUNOLOGY

Dehydroepiandrosterone alleviates E. Coli O157:H7-induced inflammation by preventing the activation of p38 MAPK and NF-κB pathways in mice peritoneal macrophages

(2019) Jinlong Zhao et al.   MOLECULAR IMMUNOLOGY

Nitidine chloride exerts anti-inflammatory action by targeting Topoisomerase I and enhancing IL-10 production

(2019) Niao Yang et al.   PHARMACOLOGICAL RESEARCH

Exosome Biogenesis in the Protozoa Parasite Giardia lamblia: A Model of Reduced Interorganellar Crosstalk

(2019) Sofía Moyano et al.   Cells

Nobiletin acts anti-inflammatory on murine IL-10−/− colitis and human intestinal fibroblasts

(2018) Yvonne Hagenlocher et al.   EUROPEAN JOURNAL OF NUTRITION

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

(2018) Kumar Vijay   INTERNATIONAL IMMUNOPHARMACOLOGY

Technical challenges of working with extracellular vesicles

(2018) Marcel I. Ramirez et al.   Nanoscale

Phloretin as a Potent Natural TLR2/1 Inhibitor Suppresses TLR2-Induced Inflammation

(2018) Jieun Kim et al.   Nutrients

Role of microRNAs and Exosomes in Helicobacter pylori and Epstein-Barr Virus Associated Gastric Cancers

(2018) Iva Polakovicova et al.   Frontiers in Microbiology

Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer’s pathology

(2018) Suresh B. Rangasamy et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP3 Inflammasome Participates in Host Response to Neospora caninum Infection

(2018) Xiaocen Wang et al.   Frontiers in Immunology

Extracellular Vesicles Secreted by Neospora caninum Are Recognized by Toll-Like Receptor 2 and Modulate Host Cell Innate Immunity Through the MAPK Signaling Pathway

(2018) Shan Li et al.   Frontiers in Immunology

The Mechanism behind Bacterial Lipoprotein Release: Phenol-Soluble Modulins Mediate Toll-Like Receptor 2 Activation via Extracellular Vesicle Release from Staphylococcus aureus

(2018) Katja Schlatterer et al.   mBio

Extracellular Vesicles in Joint Disease and Therapy

(2018) Janneke Boere et al.   Frontiers in Immunology

Microvesicles released from Giardia intestinalis disturb host-pathogen response in vitro

(2017) Ingrid Evans-Osses et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets

(2017) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

NLRP3 inflammasome activation in murine macrophages caused by Neospora caninum infection

(2017) Xiaocen Wang et al.   Parasites & Vectors

Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells

(2017) Showgy Y. Ma’ayeh et al.   PLoS Neglected Tropical Diseases

TLR2−/− Mice Display Decreased Severity of Giardiasis via Enhanced Proinflammatory Cytokines Production Dependent on AKT Signal Pathway

(2017) Xin Li et al.   Frontiers in Immunology

Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia

(2016) Anthony J. Szempruch et al.   CELL

An up-date on Giardia and giardiasis

(2016) Elin Einarsson et al.   CURRENT OPINION IN MICROBIOLOGY

Giardiasis outbreaks in the United States, 1971–2011

(2016) E. A. ADAM et al.   EPIDEMIOLOGY AND INFECTION

NLRP3 Inflammasome Activation in THP-1 Target Cells Triggered by Pathogenic Naegleria fowleri

(2016) Jong-Hyun Kim et al.   INFECTION AND IMMUNITY

Giardiasis

(2016) Corrado Minetti et al.   BMJ-British Medical Journal

Giardiasis

(2016) Corrado Minetti et al.   BMJ-British Medical Journal

Drug resistance in Giardia duodenalis

(2015) Brendan R.E. Ansell et al.   BIOTECHNOLOGY ADVANCES

Inflammasomes in host response to protozoan parasites

(2015) Dario S. Zamboni et al.   IMMUNOLOGICAL REVIEWS

Macrophages expressing arginase 1 and nitric oxide synthase 2 accumulate in the small intestine during Giardia lamblia infection

(2015) Jenny Maloney et al.   MICROBES AND INFECTION

Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain

(2015) Pragnesh Mistry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes and Other Extracellular Vesicles: The New Communicators in Parasite Infections

(2015) Gillian Coakley et al.   TRENDS IN PARASITOLOGY

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome

(2014) Tiffany Horng   TRENDS IN IMMUNOLOGY

Extracellular Vesicles from Leishmania-Infected Macrophages Confer an Anti-infection Cytokine-Production Profile to Naïve Macrophages

(2014) André Cronemberger-Andrade et al.   PLoS Neglected Tropical Diseases

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

Increased expression of CD25, CD83, and CD86, and secretion of IL-12, IL-23, and IL-10 by human dendritic cells incubated in the presence of Toll-like receptor 2 ligands and Giardia duodenalis

(2013) Janine Obendorf et al.   Parasites & Vectors

NLRP3 Inflammasome Activation by Paracoccidioides brasiliensis

(2013) Aldo Henrique Tavares et al.   PLoS Neglected Tropical Diseases

Trichomonas vaginalis Exosomes Deliver Cargo to Host Cells and Mediate Host∶Parasite Interactions

(2013) Olivia Twu et al.   PLoS Pathogens

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Signaling in Innate Immunity and Inflammation

(2012) K. Newton et al.   Cold Spring Harbor Perspectives in Biology

An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages

(2010) Judith Maxwell Silverman et al.   JOURNAL OF CELL SCIENCE

Giardiasis – why do the symptoms sometimes never stop?

(2010) Lucy J. Robertson et al.   TRENDS IN PARASITOLOGY

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS