Unravelling the proteomic signature of extracellular vesicles released by drug-resistant Leishmania infantum parasites

Impact of clinically acquired miltefosine resistance by Leishmania infantum on mouse and sand fly infection

(2020) Lieselotte Van Bockstal et al.   International Journal for Parasitology-Drugs and Drug Resistance

Exploitation of the Leishmania exosomal pathway by Leishmania RNA virus 1

(2019) Vanessa Diniz Atayde et al.   Nature Microbiology

Exosomes: biogenesis, biologic function and clinical potential

(2019) Yuan Zhang et al.   Cell and Bioscience

Modulation of Host-Pathogen Communication by Extracellular Vesicles (EVs) of the Protozoan Parasite Leishmania

(2019) George Dong et al.   Frontiers in Cellular and Infection Microbiology

Leishmania and its exosomal pathway: a novel direction for vaccine development

(2019) Martin Olivier et al.   Future Microbiology

Leishmania Viannia guyanensis

(2019) Martin Olivier et al.   TRENDS IN PARASITOLOGY

The biology of extracellular vesicles: The known unknowns

(2019) Leonid Margolis et al.   PLOS BIOLOGY

Extracellular vesicles: exosomes, microparticles, their parts, and their targets to enable their biomanufacturing and clinical applications

(2019) Chen-Yuan Kao et al.   CURRENT OPINION IN BIOTECHNOLOGY

Transmission potential of paromomycin-resistant Leishmania infantum and Leishmania donovani

(2019) S Hendrickx et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Understanding Leishmania parasites through proteomics and implications for the clinic

(2018) Shyam Sundar et al.   Expert Review of Proteomics

Extracellular vesicles: Novel mediator for cell to cell communications in liver pathogenesis

(2018) Pradip B. Devhare et al.   MOLECULAR ASPECTS OF MEDICINE

Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation

(2018) Fatima Qadir et al.   Molecular Cancer

Exosome: Function and Role in Cancer Metastasis and Drug Resistance

(2018) Chengcheng Zhang et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Outer membrane vesicles from β-lactam-resistant Escherichia coli enable the survival of β-lactam-susceptible E. coli in the presence of β-lactam antibiotics

(2018) Si Won Kim et al.   Scientific Reports

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

(2018) Tore Skotland et al.   JOURNAL OF LIPID RESEARCH

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

UniProt: a worldwide hub of protein knowledge

(2018)   NUCLEIC ACIDS RESEARCH

Role of inhibitors of serine peptidases in protecting Leishmania donovani against the hydrolytic peptidases of sand fly midgut

(2017) Sudha Verma et al.   Parasites & Vectors

Exploiting Knowledge on Leishmania Drug Resistance to Support the Quest for New Drugs

(2017) Aya Hefnawy et al.   TRENDS IN PARASITOLOGY

Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress

(2017) Deepak Kumar Deep et al.   PLoS Neglected Tropical Diseases

Social and Economic Burden of Human Leishmaniasis

(2016) Ifeoma Okwor et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia

(2016) Anthony J. Szempruch et al.   CELL

Leishmania exosomes and other virulence factors: Impact on innate immune response and macrophage functions

(2016) Vanessa Diniz Atayde et al.   CELLULAR IMMUNOLOGY

Sending a message: extracellular vesicles of pathogenic protozoan parasites

(2016) Anthony J. Szempruch et al.   NATURE REVIEWS MICROBIOLOGY

A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani

(2016) P. Vacchina et al.   Parasites & Vectors

DDX3 DEAD-box RNA helicase plays a central role in mitochondrial protein quality control in Leishmania

(2016) Prasad Kottayil Padmanabhan et al.   Cell Death & Disease

Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria

(2016) Pierre-Yves Mantel et al.   Nature Communications

Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms

(2016) Christopher Fernandez-Prada et al.   PLoS Neglected Tropical Diseases

Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles

(2015) Diana Sousa et al.   TRENDS IN MOLECULAR MEDICINE

Exosome Secretion by the Parasitic Protozoan Leishmania within the Sand Fly Midgut

(2015) Vanessa Diniz Atayde et al.   Cell Reports

Drug resistance analysis by next generation sequencing in Leishmania

(2015) Philippe Leprohon et al.   International Journal for Parasitology-Drugs and Drug Resistance

Transmission Potential of Antimony-Resistant Leishmania Field Isolates

(2014) Veronika Seblova et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

InterProScan 5: genome-scale protein function classification

(2014) P. Jones et al.   BIOINFORMATICS

Stage-Dependent Expression and Up-Regulation of Trypanothione Synthetase in Amphotericin B Resistant Leishmania donovani

(2014) Asif Equbal et al.   PLoS One

Absence of Metalloprotease GP63 Alters the Protein Content of Leishmania Exosomes

(2014) Kasra Hassani et al.   PLoS One

Epidemiology of Visceral Leishmaniasis in Georgia

(2014) Giorgi Babuadze et al.   PLoS Neglected Tropical Diseases

Visceral Leishmaniasis Outbreak in South Sudan 2009–2012: Epidemiological Assessment and Impact of a Multisectoral Response

(2014) Abdinasir Abubakar et al.   PLoS Neglected Tropical Diseases

Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum

(2014) Marie-Christine Brotherton et al.   International Journal for Parasitology-Drugs and Drug Resistance

An outbreak investigation of visceral leishmaniasis among residents of Dharan town, eastern Nepal, evidence for urban transmission of Leishmania donovani

(2013) Surendra Uranw et al.   BMC INFECTIOUS DISEASES

Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles

(2013) Neta Regev-Rudzki et al.   CELL

Malaria-Infected Erythrocyte-Derived Microvesicles Mediate Cellular Communication within the Parasite Population and with the Host Immune System

(2013) Pierre-Yves Mantel et al.   Cell Host & Microbe

Re-emergence of leishmaniasis in Spain: community outbreak in Madrid, Spain, 2009 to 2012

(2013) A Arce et al.   Eurosurveillance

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Exoproteome dynamics in Leishmania infantum

(2013) Nuno Santarém et al.   Journal of Proteomics

Proteomic and Genomic Analyses of Antimony Resistant Leishmania infantum Mutant

(2013) Marie-Christine Brotherton et al.   PLoS One

Determinants for the Development of Visceral Leishmaniasis Disease

(2013) Laura-Isobel McCall et al.   PLoS Pathogens

Biomarkers of antimony resistance: need for expression analysis of multiple genes to distinguish resistance phenotype in clinical isolates of Leishmania donovani

(2012) Dhiraj Kumar et al.   PARASITOLOGY RESEARCH

Impact of Leishmania metalloprotease GP63 on macrophage signaling

(2012) Amandine Isnard et al.   Frontiers in Cellular and Infection Microbiology

Differential expression of proteins in antimony-susceptible and -resistant isolates of Leishmania donovani

(2011) Neha Biyani et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

SignalP 4.0: discriminating signal peptides from transmembrane regions

(2011) Thomas Nordahl Petersen et al.   NATURE METHODS

LeishVet guidelines for the practical management of canine leishmaniosis

(2011) Laia Solano-Gallego et al.   Parasites & Vectors

Increased metacyclogenesis of antimony-resistant Leishmania donovani clinical lines

(2011) M. OUAKAD et al.   PARASITOLOGY

Temperature-Induced Protein Secretion by Leishmania mexicana Modulates Macrophage Signalling and Function

(2011) Kasra Hassani et al.   PLoS One

Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania

(2011) W Moreira et al.   Cell Death & Disease

FISH analysis reveals aneuploidy and continual generation of chromosomal mosaicism in Leishmania major

(2010) Yvon Sterkers et al.   CELLULAR MICROBIOLOGY

Role of spectral counting in quantitative proteomics

(2010) Deborah H Lundgren et al.   Expert Review of Proteomics

The SPRY domain–containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

(2010) Zhihe Kuang et al.   JOURNAL OF CELL BIOLOGY

An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages

(2010) Judith Maxwell Silverman et al.   JOURNAL OF CELL SCIENCE

NetPath: a public resource of curated signal transduction pathways

(2010) Kumaran Kandasamy et al.   GENOME BIOLOGY

Cellular Transport and Lipid Interactions of Miltefosine

(2009) Gillian Barratt et al.   CURRENT DRUG METABOLISM

Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum

(2009) P. Leprohon et al.   NUCLEIC ACIDS RESEARCH

TriTrypDB: a functional genomic resource for the Trypanosomatidae

(2009) Martin Aslett et al.   NUCLEIC ACIDS RESEARCH

Influence of parasite encoded inhibitors of serine peptidases in early infection of macrophages withLeishmania major

(2008) Sylvain C. P. Eschenlauer et al.   CELLULAR MICROBIOLOGY

Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy

(2008) Jean-Michel Ubeda et al.   GENOME BIOLOGY

Proteomic analysis of the secretome of Leishmania donovani

(2008) J Maxwell Silverman et al.   GENOME BIOLOGY