Independent domains for recruitment of PRC1 and PRC2 by human XIST

X chromosome inactivation in human development

(2020) Catherine Patrat et al.   DEVELOPMENT

The many faces of Polycomb regulation by RNA

(2020) Mafalda Almeida et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Xist drives spatial compartmentalization of DNA and protein to orchestrate initiation and maintenance of X inactivation

(2020) Mackenzie Strehle et al.   CURRENT OPINION IN CELL BIOLOGY

Xist Repeats A and B Account for Two Distinct Phases of X Inactivation Establishment

(2020) David Colognori et al.   DEVELOPMENTAL CELL

Progress toward understanding chromosome silencing by Xist RNA

(2020) Neil Brockdorff et al.   GENES & DEVELOPMENT

Elements at the 5′ end of Xist harbor SPEN-independent transcriptional antiterminator activity

(2020) Jackson B Trotman et al.   NUCLEIC ACIDS RESEARCH

Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X

(2019) David Colognori et al.   MOLECULAR CELL

Histone variant macroH2A: from chromatin deposition to molecular function

(2019) Zhen Sun et al.   Essays in Biochemistry

PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments

(2019) Chen-Yu Wang et al.   Nature Communications

Xist RNA in action: Past, present, and future

(2019) Agnese Loda et al.   PLoS Genetics

SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X

(2018) Chen-Yu Wang et al.   CELL

Transcription-associated histone pruning demarcates macroH2A chromatin domains

(2018) Zhen Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Implication of Early Chromatin Changes in X Chromosome Inactivation

(2018) Jan Jakub Żylicz et al.   CELL

The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome

(2018) Michal R. Gdula et al.   Nature Communications

Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro

(2018) Jen-Chieh Chiang et al.   Nature Communications

Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway

(2018) Natasha Jansz et al.   Cell Reports

hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing

(2017) Greta Pintacuda et al.   MOLECULAR CELL

CRISPR/Cas9-mediated modulation of splicing efficiency reveals short splicing isoform of Xist RNA is sufficient to induce X-chromosome inactivation

(2017) Minghui Yue et al.   NUCLEIC ACIDS RESEARCH

Polycomb complexes in X chromosome inactivation

(2017) Neil Brockdorff   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

PCGF3/5–PRC1 initiates Polycomb recruitment in X chromosome inactivation

(2017) Mafalda Almeida et al.   SCIENCE

Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation

(2017) Sanjeet Patel et al.   Cell Reports

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

(2016) Sophie Petropoulos et al.   CELL

SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across theXistlncRNA in living cells

(2016) Matthew J. Smola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

D-repeat in theXISTgene is required for X chromosome inactivation

(2016) Qingyan Lv et al.   RNA Biology

A Tale of Two Cities: How Xist and its partners localize to and silence the bicompartmental X

(2016) Stefan F. Pinter   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2

(2016) Sarah Cooper et al.   Nature Communications

Systematic Discovery of Xist RNA Binding Proteins

(2015) Ci Chu et al.   CELL

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

(2015) Colleen A. McHugh et al.   NATURE

A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation

(2015) A. Minajigi et al.   SCIENCE

Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells

(2015) Asun Monfort et al.   Cell Reports

Differentially methylated CpG island within human XIST mediates alternative P2 transcription and YY1 binding

(2014) Andrew G Chapman et al.   BMC GENETICS

Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome

(2014) Simão Teixeira da Rocha et al.   MOLECULAR CELL

Translating dosage compensation to trisomy 21

(2013) Jun Jiang et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells

(2013) Jakub Minks et al.   Epigenetics & Chromatin

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

(2012) Sharad K. Verma et al.   ACS Medicinal Chemistry Letters

A scaffold for X chromosome inactivation

(2011) Anna Tattermusch et al.   HUMAN GENETICS

The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation

(2010) Morgan E Royce-Tolland et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SATB1 Defines the Developmental Context for Gene Silencing by Xist in Lymphoma and Embryonic Cells

(2009) Ruben Agrelo et al.   DEVELOPMENTAL CELL

The E3 Ubiquitin-Ligase Bmi1/Ring1A Controls the Proteasomal Degradation of Top2α Cleavage Complex – A Potentially New Drug Target

(2009) Iris Alchanati et al.   PLoS One

A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse

(2008) Y. Hoki et al.   DEVELOPMENT