Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro
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Title
Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro
Authors
Keywords
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Journal
Nature Communications
Volume 9, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-11-29
DOI
10.1038/s41467-018-07630-y
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Note: Only part of the references are listed.- Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium
- (2018) Michael Lie-A-Ling et al. DEVELOPMENT
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- Down syndrome and the complexity of genome dosage imbalance
- (2016) Stylianos E. Antonarakis NATURE REVIEWS GENETICS
- Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities
- (2016) Kimihiko Banno et al. Cell Reports
- Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update
- (2016) Neha Bhatnagar et al. Current Hematologic Malignancy Reports
- Trisomy 21 consistently activates the interferon response
- (2016) Kelly D Sullivan et al. eLife
- Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast
- (2015) Heidi M. Blank et al. MOLECULAR BIOLOGY OF THE CELL
- Gene therapy returns to centre stage
- (2015) Luigi Naldini NATURE
- Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages
- (2015) Andrea Ditadi et al. NATURE CELL BIOLOGY
- Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells
- (2014) Christopher M Sturgeon et al. NATURE BIOTECHNOLOGY
- Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation
- (2014) Andrew A Lane et al. NATURE GENETICS
- Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators
- (2014) Irina Elcheva et al. Nature Communications
- A short history of hemogenic endothelium
- (2013) Gemma Swiers et al. BLOOD CELLS MOLECULES AND DISEASES
- Translating dosage compensation to trisomy 21
- (2013) Jun Jiang et al. NATURE
- GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment
- (2012) C. Lancrin et al. BLOOD
- Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and Their Differentiated Derivatives
- (2012) Kristopher L. Nazor et al. Cell Stem Cell
- Aneuploidy causes proteotoxic stress in yeast
- (2012) A. B. Oromendia et al. GENES & DEVELOPMENT
- Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21
- (2012) A. Roy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells
- (2012) S. T. Chou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells
- (2012) G. A. MacLean et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of the Hemogenic Endothelial Progenitor and Its Direct Precursor in Human Pluripotent Stem Cell Differentiation Cultures
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- (2012) Marion Kennedy et al. Cell Reports
- Infections and immunodeficiency in Down syndrome
- (2011) G. Ram et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Hematological disorders and leukemia in children with Down syndrome
- (2011) Annelyse Bruwier et al. EUROPEAN JOURNAL OF PEDIATRICS
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- Intrinsic defect of the immune system in children with Down syndrome: a review
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- The 50th anniversary of the discovery of trisomy 21: The past, present, and future of research and treatment of Down syndrome
- (2009) André Mégarbané et al. GENETICS IN MEDICINE
- Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter
- (2009) Michael J. Chen et al. NATURE
- Hematopoietic and endothelial differentiation of human induced pluripotent stem cells
- (2009) Kyung-Dal Choi et al. STEM CELLS
- Molecular basis of pharmacotherapies for cognition in Down syndrome
- (2009) Katheleen J. Gardiner TRENDS IN PHARMACOLOGICAL SCIENCES
- Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations
- (2008) O. Tunstall-Pedoe et al. BLOOD
- Trisomy 21 enhances human fetal erythro-megakaryocytic development
- (2008) S. T. Chou et al. BLOOD
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- (2008) M. Cristina Nostro et al. Cell Stem Cell
- X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected
- (2008) Lisa L. Hall et al. JOURNAL OF CELLULAR PHYSIOLOGY
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