Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity

B cells are associated with survival and immunotherapy response in sarcoma

(2020) Florent Petitprez et al.   NATURE

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

(2020) Rita Cabrita et al.   NATURE

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

A conserved dendritic-cell regulatory program limits antitumour immunity

(2020) Barbara Maier et al.   NATURE

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling

(2020) Junbin Qian et al.   CELL RESEARCH

Anti-Metastasis Fascin Inhibitors Decrease the Growth of Specific Subtypes of Cancers

(2020) Yufeng Wang et al.   Cancers

Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer

(2019) Cindy Hodakoski et al.   Cancers

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments

(2019) Shengchen Lin et al.   Cell Reports

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

(2019) Qiming Zhang et al.   CELL

Long-Term Exposure to Inflammation Induces Differential Cytokine Patterns and Apoptosis in Dendritic Cells

(2019) Laura Stentoft Carstensen et al.   Frontiers in Immunology

NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis

(2018) Ariella Glasner et al.   IMMUNITY

Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor

(2018) Jianyun Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

MEF2 plays a significant role in the tumor inhibitory mechanism of encapsulated RENCA cells via EGF receptor signaling in target tumor cells

(2018) Prithy C. Martis et al.   BMC CANCER

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

Importance of EMT Factor ZEB1 in cDC1 “MutuDC Line” Mediated Induction of Th1 Immune Response

(2018) Shuchi Smita et al.   Frontiers in Immunology

Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress

(2017) Baran A. Ersoy et al.   JOURNAL OF CLINICAL INVESTIGATION

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Foxp3-independent mechanism by which TGF-β controls peripheral T cell tolerance

(2017) Soyoung A. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination immunotherapy: a road map

(2017) Patrick A. Ott et al.   Journal for ImmunoTherapy of Cancer

Improving fascin inhibitors to block tumor cell migration and metastasis

(2016) Shaoqin Han et al.   Molecular Oncology

Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

(2016) Kelly D Moynihan et al.   NATURE MEDICINE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization

(2015) Fang-Ke Huang et al.   Nature Communications

Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells

(2015) Mélanie Chabaud et al.   Nature Communications

Fascin Plays a Role in Stress Fiber Organization and Focal Adhesion Disassembly

(2014) Nadia Elkhatib et al.   CURRENT BIOLOGY

Conditional expression of fascin increases tumor progression in a mouse model of intestinal cancer

(2014) Marie Schoumacher et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Fascin Is Regulated by Slug, Promotes Progression of Pancreatic Cancer in Mice, and Is Associated With Patient Outcomes

(2014) Ang Li et al.   GASTROENTEROLOGY

A Signal Transducer and Activator of Transcription 3·Nuclear Factor κB (Stat3·NFκB) Complex Is Necessary for the Expression of Fascin in Metastatic Breast Cancer Cells in Response to Interleukin (IL)-6 and Tumor Necrosis Factor (TNF)-α

(2014) Marylynn Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determining the macropinocytic index of cells through a quantitative image-based assay

(2014) Cosimo Commisso et al.   Nature Protocols

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

(2014) K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis

(2013) Vanessa Y Tan et al.   BMC Medicine

Molecular Mechanism of Fascin Function in Filopodial Formation

(2012) Shengyu Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide-Activated Dendritic Cells: "Exhausted" or Alert and Waiting?

(2012) K. Abdi et al.   JOURNAL OF IMMUNOLOGY

Novel Murine Dendritic Cell Lines: A Powerful Auxiliary Tool for Dendritic Cell Research

(2012) Silvia A. Fuertes Marraco et al.   Frontiers in Immunology

Signal Transducers and Activators of Transcription 3 (STAT3) Directly Regulates Cytokine-induced Fascin Expression and Is Required for Breast Cancer Cell Migration

(2011) Marylynn Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fascin1 Promotes Cell Migration of Mature Dendritic Cells

(2011) Y. Yamakita et al.   JOURNAL OF IMMUNOLOGY

The roles of fascins in health and disease

(2011) Yosuke Hashimoto et al.   JOURNAL OF PATHOLOGY

Dendritic Cell Inhibition Is Connected to Exhaustion of CD8+ T Cell Polyfunctionality during Chronic Hepatitis C Virus Infection

(2010) I. G. Rodrigue-Gervais et al.   JOURNAL OF IMMUNOLOGY

Migrastatin analogues target fascin to block tumour metastasis

(2010) Lin Chen et al.   NATURE

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

Matrix Architecture Dictates Three-Dimensional Migration Modes of Human Macrophages: Differential Involvement of Proteases and Podosome-Like Structures

(2009) E. Van Goethem et al.   JOURNAL OF IMMUNOLOGY

Assembly and biological role of podosomes and invadopodia

(2008) Mario Gimona et al.   CURRENT OPINION IN CELL BIOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE