Multivalent Aptamer‐Functionalized Single‐Strand RNA Origami as Effective, Target‐Specific Anticoagulants with Corresponding Reversal Agents

Recent Advances in Aptamer Discovery and Applications

(2019) Yang Zhang et al.   MOLECULES

Genetically Encoded, Functional Single‐Strand RNA Origami: Anticoagulant

(2019) Abhichart Krissanaprasit et al.   ADVANCED MATERIALS

DNA Nanoscaffold‐Assisted Selection of Femtomolar Bivalent Aptamers for Human α‐Thrombin with Potent Anticoagulant Activity

(2019) Yu Zhou et al.   CHEMBIOCHEM

Out-of-Plane Aptamer Functionalization of RNA Three-Helix Tiles

(2019) Aradhana Chopra et al.   Nanomaterials

In vivo production of RNA nanostructures via programmed folding of single-stranded RNAs

(2018) Mo Li et al.   Nature Communications

Development of a genetically encodable FRET system using fluorescent RNA aptamers

(2018) Mette D. E. Jepsen et al.   Nature Communications

Composing RNA Nanostructures from a Syntax of RNA Structural Modules

(2017) Cody Geary et al.   NANO LETTERS

Single-stranded DNA and RNA origami

(2017) Dongran Han et al.   SCIENCE

Analysis of aptamer discovery and technology

(2017) Matthew R. Dunn et al.   Nature Reviews Chemistry

Programmed Switching of Single Polymer Conformation on DNA Origami

(2016) Abhichart Krissanaprasit et al.   ACS Nano

Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer

(2016) Thomas J. Povsic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer

(2016) Nancy J. Ganson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Cellular Delivery of RNA Nanoparticles

(2016) Lorena Parlea et al.   ACS Combinatorial Science

Modulation of the Coagulation Cascade Using AptamersSignificance

(2015) Rebecca S. Woodruff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Routing of individual polymers in designed patterns

(2015) Jakob Bach Knudsen et al.   Nature Nanotechnology

Transcription yield of fully 2′-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants

(2015) Adam J. Meyer et al.   NUCLEIC ACIDS RESEARCH

New oral anticoagulants: their advantages and disadvantages compared with vitamin K antagonists in the prevention and treatment of patients with thromboembolic events

(2015) Agon Mekaj et al.   Therapeutics and Clinical Risk Management

Venous thrombosis

(2015) Alisa S. Wolberg et al.   Nature Reviews Disease Primers

Toward Larger DNA Origami

(2014) Alexandria N. Marchi et al.   NANO LETTERS

A single-stranded architecture for cotranscriptional folding of RNA nanostructures

(2014) C. Geary et al.   SCIENCE

Inhibiting the intrinsic pathway of coagulation with a factor XII-targeting RNA aptamer

(2013) R. S. Woodruff et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity

(2012) K. M. BOMPIANI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Direct thrombin inhibitors

(2011) Catherine J. Lee et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

(2011) R. Tonelli et al.   CLINICAL CANCER RESEARCH

Increased anticoagulant activity of thrombin-binding DNA aptamers by nanoscale organization on DNA nanostructures

(2011) Abhijit Rangnekar et al.   Nanomedicine-Nanotechnology Biology and Medicine

Peptide Nucleic Acids (PNA) in Chemical Biology and Drug Discovery

(2010) Peter E. Nielsen   CHEMISTRY & BIODIVERSITY

Development of aptamer therapeutics

(2010) David HJ Bunka et al.   CURRENT OPINION IN PHARMACOLOGY

NUPACK: Analysis and design of nucleic acid systems

(2010) Joseph N. Zadeh et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Weave Tile Architecture Construction Strategy for DNA Nanotechnology

(2010) Majken N. Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

An Anticoagulant RNA Aptamer That Inhibits Proteinase-Cofactor Interactions within Prothrombinase

(2009) Sai K. Buddai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self-assembly of DNA into nanoscale three-dimensional shapes

(2009) Shawn M. Douglas et al.   NATURE

Self-assembly of a nanoscale DNA box with a controllable lid

(2009) Ebbe S. Andersen et al.   NATURE

Phase 1b Randomized Study of Antidote-Controlled Modulation of Factor IXa Activity in Patients With Stable Coronary Artery Disease

(2008) Mark Y. Chan et al.   CIRCULATION

SELEX with modified nucleotides

(2008) Anthony D Keefe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A randomized, repeat-dose, pharmacodynamic and safety study of an antidote-controlled factor IXa inhibitor

(2008) M. Y. CHAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Crystal structure of an RNA aptamer bound to thrombin

(2008) S. B. Long et al.   RNA