Inhibiting the intrinsic pathway of coagulation with a factor XII-targeting RNA aptamer

In vivo roles of factor XII

(2012) T. Renne et al.   BLOOD

A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity

(2012) K. M. BOMPIANI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

(2011) A. S. Revenko et al.   BLOOD

Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy

(2011) T. J. Povsic et al.   EUROPEAN HEART JOURNAL

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo

(2010) Q. Cheng et al.   BLOOD

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk

(2010) H. Zhang et al.   BLOOD

Dual role of collagen in factor XII-dependent thrombus formation

(2009) P. E. J. van der Meijden et al.   BLOOD

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

(2009) Felicitas Müller et al.   CELL

An Anticoagulant RNA Aptamer That Inhibits Proteinase-Cofactor Interactions within Prothrombinase

(2009) Sai K. Buddai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of universal antidotes to control aptamer activity

(2009) Sabah Oney et al.   NATURE MEDICINE

Factor XII: What does it contribute to our understanding of the physiology and pathophysiology of hemostasis & thrombosis

(2009) Evi Stavrou et al.   THROMBOSIS RESEARCH

SELEX with modified nucleotides

(2008) Anthony D Keefe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Crystal structure of an RNA aptamer bound to thrombin

(2008) S. B. Long et al.   RNA