Canagliflozin Facilitates Reverse Cholesterol Transport Through Activation of AMPK/ABC Transporter Pathway

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

(2020) Asier González et al.   Cell Metabolism

Lipid efflux mechanisms, relation to disease and potential therapeutic aspects

(2020) David Castaño et al.   ADVANCED DRUG DELIVERY REVIEWS

SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease

(2020) So Ra Kim et al.   Nature Communications

The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice

(2020) Emily A. Day et al.   BIOCHEMICAL JOURNAL

LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight from Mouse Models

(2020) Lidia Cedo et al.   CIRCULATION RESEARCH

Genetic variability in the absorption of dietary sterols affects the risk of coronary artery disease

(2020) Anna Helgadottir et al.   EUROPEAN HEART JOURNAL

Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles

(2020) Yi He et al.   CIRCULATION RESEARCH

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Brothers in Arms: ABCA1- and ABCG1-Mediated Cholesterol Efflux as Promising Targets in Cardiovascular Disease Treatment

(2019) Sanne J. C. M. Frambach et al.   PHARMACOLOGICAL REVIEWS

Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic ConsequencesHighlights

(2018) Matthew M. Molusky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Canagliflozin exerts anti-inflammatory effects by inhibiting intracellular glucose metabolism and promoting autophagy in immune cells

(2018) Chenke Xu et al.   BIOCHEMICAL PHARMACOLOGY

Liver X receptors in lipid signalling and membrane homeostasis

(2018) Bo Wang et al.   Nature Reviews Endocrinology

Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms

(2018) Sarah J. Mancini et al.   Scientific Reports

Mechanism of Increased LDL (Low-Density Lipoprotein) and Decreased Triglycerides With SGLT2 (Sodium-Glucose Cotransporter 2) Inhibition

(2018) Debapriya Basu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Canagliflozin attenuates the progression of atherosclerosis and inflammation process in APOE knockout mice

(2018) Νarjes Nasiri-Ansari et al.   Cardiovascular Diabetology

Puerarin promotes ABCA1-mediated cholesterol efflux and decreases cellular lipid accumulation in THP-1 macrophages

(2017) Cong-hui Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Streptozotocin-Treated High Fat Fed Mice: A New Type 2 Diabetes Model Used to Study Canagliflozin-Induced Alterations in Lipids and Lipoproteins

(2017) Tian Yu et al.   HORMONE AND METABOLIC RESEARCH

AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE −/− mice

(2017) Ang Ma et al.   JOURNAL OF LIPID RESEARCH

Canagliflozin for Primary and Secondary Prevention of Cardiovascular Events

(2017) Kenneth W. Mahaffey et al.   CIRCULATION

Effects of canagliflozin on weight loss in high-fat diet-induced obese mice

(2017) Wenjun Ji et al.   PLoS One

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

(2016) Simon A. Hawley et al.   DIABETES

AMPK activates LXRα and ABCA1 expression in human macrophages

(2016) Marina Kemmerer et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

(2015) Adam L. Bujak et al.   Cell Metabolism

Clinical Pharmacokinetic, Pharmacodynamic, and Drug–Drug Interaction Profile of Canagliflozin, a Sodium-Glucose Co-transporter 2 Inhibitor

(2015) Damayanthi Devineni et al.   CLINICAL PHARMACOKINETICS

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk

(2015) Morgan D. Fullerton et al.   JOURNAL OF LIPID RESEARCH

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

(2015) Leigh Goedeke et al.   NATURE MEDICINE

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

(2015) Jimmy F. P. Berbée et al.   Nature Communications

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk

(2014) Fleur Lien et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: findings from the 52-week CANTATA-M study

(2013) Kaj Stenlöf et al.   CURRENT MEDICAL RESEARCH AND OPINION

Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise

(2012) K. Stenlöf et al.   DIABETES OBESITY & METABOLISM

Effect of Macrophage Overexpression of Murine Liver X Receptor -α ( LXR -α) on Atherosclerosis in LDL-Receptor Deficient Mice

(2008) Daniel Teupser et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY