Article
Chemistry, Multidisciplinary
Kam Sang Kwok, Yi Zuo, Soo Jin Choi, Gayatri J. Pahapale, Luo Gu, David H. Gracias
Summary: Lithographic nanopatterning techniques have been widely used in electronics and optics, but their application in nanobio interfaces is limited by cytotoxicity and 2D features. This article presents a biocompatible and cost-effective transfer process using nanoimprint lithography and alginate hydrogel to create flexible and degradable transfer layers. Biotransfer printing of the nanopattern arrays on live cells and animal brains demonstrates high pattern fidelity and cell viability. This method has great potential in advancing bionics, biosensing, and biohybrid tissue interfaces.
Article
Chemistry, Physical
Jianqiao Chang, Yu Zhang, Yike Li, Ziwei Han, Fei Tian, Chao Liu, Qiang Feng, Yuguang Wang, Jiashu Sun, Lu Zhang
Summary: This study introduces a multilayer ratiometric fluorescent nanomachine for live-cell perturbation and imaging of mRNA at single cell resolution, offering great potential for quantifying mRNA expression and modulating and imaging intratumoral mRNA.
Review
Chemistry, Analytical
Yangwon Jeon, Yejin Lee, Keugtae Kim, Geupil Jang, Youngdae Yoon
Summary: Microorganisms are omnipresent and have a significant impact on human health and safety. New methods have been developed to detect microorganisms and toxins, compensating for the limitations of traditional techniques.
Article
Chemistry, Analytical
Ze Fan, Cai-Xia Dou, Li-Juan Tang, Fenglin Wang, Jian-Hui Jiang
Summary: Genetically encoded sensors with a modular design have been developed for ratiometric and multiplexed imaging of small molecules in live cells. The sensors use aptazyme as a recognition module and light-up RNA aptamer as a signal reporter. The design allows for quantitative imaging and detection of small molecules, and the versatility of the approach is demonstrated by replacing the aptazymes for imaging different molecules.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Hui Jin, Zejun Sun, Yujiao Sun, Rijun Gui
Summary: Dual-signal ratiometric platforms (DSRPs) offer built-in correction for background signal interference, leading to improved accuracy and reliability in target detection. This review outlines the construction principles and biosensing applications of DSRPs, emphasizing their utility at live cell and small animal levels.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Environmental
Zhihang Zhao, Xuerong Shi, Zhiwei Shen, Yue Gu, Liang He, Min Zhang, Na Lu
Summary: This study reports a new Fe-N-C catalyst that achieves high catalytic activity by tuning the geometric and electronic configurations of single atoms and atomic clusters. The catalyst exhibits oxidase-mimicking activity and is used for biochemical sensing applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Spectroscopy
Nengtao Wu, Qin Wen, Qianming Wang
Summary: Polymer dots with color-tunable fluorescence capabilities were synthesized through a one-step strategy, allowing for emission peak adjustment over a range of excitation wavelengths for quantitative detection of trace metal ions, suitable for applications in biomedicine and environmental protection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Inorganic & Nuclear
Zein El Abidine Aly Taleb, Kamel Saidi, Mohamed Dammak, Dominika Przybylska, Tomasz Grzyb
Summary: This paper proposes a new single-band ratiometric thermometry technique based on both the ground and excited state absorption processes. By adjusting the concentration of terbium ions and the optical properties of the doped phosphors, accurate temperature measurement and thermally stable cold light emission are achieved.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Analytical
Qingyi Han, Dingding Zhang, Rui Zhang, Jianpu Tang, Keying Xu, Mingzheng Shao, Yuyan Li, Peiyao Du, Ruizhong Zhang, Dayong Yang, Libing Zhang, Xiaoquan Lu
Summary: A DNA-functionalized metal-organic framework (MOF)-based ratiometric fluorescent probe was developed for sensitive detection and imaging of miRNA-21 in living cells. The probe achieved picomolar limit detection without signal amplification and allowed imaging of intracellular miRNA-21 through strand-displacement reaction, enabling discrimination between cancer cells and normal cells. This work presents a new approach for intracellular molecular analysis and has significant implications for early disease diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Ali Khodadoust, Navid Nasirizadeh, Ramezan Ali Taheri, Mohammad Dehghani, Mostafa Ghanei, Hasan Bagheri
Summary: A sensitive biosensor has been developed for the detection of miR-141, which shows potential for early diagnosis of non-small cell lung cancer. The biosensor exhibited a low detection limit and a wide linear range, indicating its effectiveness in clinical applications.
Article
Chemistry, Multidisciplinary
Xiangnan Wang, Xin Yi, Zhimei Huang, Jianjun He, Zhenkun Wu, Xia Chu, Jian-Hui Jiang
Summary: In this study, a repaired and activated DNAzyme (RADzyme) was developed by incorporating single methyl lesions at designated positions. This technology allowed the development of a fluorogenic RADzyme sensor for monitoring DNA repair, facilitating evaluation of repair activity in different cells and under drug treatment. This strategy provides a simple and versatile tool for the study of DNA repair biology, clinical diagnosis, and therapeutic assessment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Xijuan Chao, Yan Hu, Rongjian Liu, Dejun Huang, Yingmei Zhang
Summary: Changes in lysosomal polarity are important indicators of cell status in physiological and pathological processes, and can be used as markers for cancer detection. The DCM-ML probe is highly sensitive to polarity, making it a potential tool for cancer cell diagnosis and real-time monitoring of cell and zebrafish processes. Its development could contribute to research on lysosome-related physiological and pathological processes.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Hongshuai Zhang, Tao Zhao, Peifeng Huang, Qingsong Wang, Hao Tang, Xia Chu, Jianhui Jiang
Summary: This study developed a dual-nanopore biosensor for label-free and spatiotemporal monitoring of proteins in living cells. By using affinity-tunable peptide probes, the sensor demonstrated reversible and sensitive detection of protein kinase A (PKA) catalytic subunit, with the ability to effectively eliminate interferences from cell membrane resistance and coexisting species. The sensor was also applied successfully in monitoring dynamic PKA activity changes under different stimulations in single live cells.
Article
Spectroscopy
Youming Shen, Xiangyang Zhang, Chunxiang Zhang, Yucai Tang
Summary: HClO and H2S play various roles in biological organisms, and the redox balance between them is closely related to physiological and pathological processes. Therefore, developing a reversible ratiometric fluorescent probe for monitoring the redox process between HClO and H2S is of great significance.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Hui Heng, Qingyang Gu, Haibo Jin, Ping Shen, Jiaxin Wei, Xinyu Er, Jia Sun
Summary: A novel ratiometric fluorescence nanoprobe has been developed to selectively and sensitively detect tryptophan enantiomers. The nanoprobe shows excellent linearity, selectivity, and specific recognition, and can achieve visual detection in actual samples.
Meeting Abstract
Biophysics
Patrick G. Robison, Jaclyn P. Kerr, Alexey I. Bogush, Daniel A. Harki, Christopher W. Ward, Benjamin L. Prosser
BIOPHYSICAL JOURNAL
(2015)
Meeting Abstract
Biophysics
Jaclyn P. Kerr, Benjamin L. Prosser, Guoli Shi, Patrick Robison, Aaron M. Kempema, Joseph K. Hexum, Daniel A. Harki, Stuart S. Martin, Roberto Raiteri, Christopher W. Ward
BIOPHYSICAL JOURNAL
(2015)
Article
Multidisciplinary Sciences
Jaclyn P. Kerr, Patrick Robison, Guoli Shi, Alexey I. Bogush, Aaron M. Kempema, Joseph K. Hexum, Natalia Becerra, Daniel A. Harki, Stuart S. Martin, Roberto Raiteri, Benjamin L. Prosser, Christopher W. Ward
NATURE COMMUNICATIONS
(2015)
Article
Multidisciplinary Sciences
Maegen A. Ackermann, Jaclyn P. Kerr, Brendan King, Christopher W. Ward, Aikaterini Kontrogianni-Konstantopoulos
SCIENTIFIC REPORTS
(2015)
Meeting Abstract
Biophysics
Jaclyn P. Kerr, Guoli Shi, W. Jonathan Lederer, Kelley M. Virgilio, Sylvia S. Blemker, Stuart S. Martin, Roberto Raiteri, Christopher W. Ward
BIOPHYSICAL JOURNAL
(2016)
Article
Biochemistry & Molecular Biology
James S. Lyons, Humberto C. Joca, Robert A. Law, Katrina M. Williams, Jaclyn P. Kerr, Guoli Shi, Ramzi J. Khairallah, Stuart S. Martin, Konstantinos Konstantopoulos, Christopher W. Ward, Joseph P. Stains
Article
Biochemistry & Molecular Biology
James S. Lyons, Humberto C. Joca, Robert A. Law, Katrina M. Williams, Jaclyn P. Kerr, Guoli Shi, Ramzi J. Khairallah, Stuart S. Martin, Konstantinos Konstantopoulos, Christopher W. Ward, Joseph P. Stains
Correction
Multidisciplinary Sciences
Maegen A. Ackermann, Jaclyn P. Kerr, Brendan King, Christopher W. Ward, Aikaterini Kontrogianni-Konstantopoulos
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Stephen J. P. Pratt, Sameer B. Shah, Christopher W. Ward, Jaclyn P. Kerr, Joseph P. Stains, Richard M. Lovering
CELLULAR AND MOLECULAR LIFE SCIENCES
(2015)
Correction
Cell Biology
Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell
Article
Cell Biology
Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell
Article
Cell Biology
Joaquin M. Muriel, Andrea O'Neill, Jaclyn P. Kerr, Emily Kleinhans-Welte, Richard M. Lovering, Robert J. Bloch
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Medicine, Research & Experimental
Hengtao Zhang, Victoria Graham Bryson, Chaojian Wang, TianYu Li, Jaclyn P. Kerr, Rebecca Wilson, Deborah M. Muoio, Robert J. Bloch, Christopher Ward, Paul B. Rosenberg
Summary: Desmin interacts with STIM1 to assemble a cytoskeletal-SR connection important for Ca2+ signaling in skeletal muscle.
Article
Cell & Tissue Engineering
Atum M. Buo, Mark S. Williams, Jaclyn P. Kerr, Joseph P. Stains