Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

(2017) Daniela Massihnia et al.   Journal of Hematology & Oncology

PI(3,4,5)P 3 Engagement Restricts Akt Activity to Cellular Membranes

(2017) Michael Ebner et al.   MOLECULAR CELL

miR-92a promotes tumor growth of osteosarcoma by targeting PTEN/AKT signaling pathway

(2017) Jie Xiao et al.   ONCOLOGY REPORTS

Up-regulation of BRCA1-associated RING Domain 1 Promotes Hepatocellular Carcinoma Progression by Targeting Akt Signaling

(2017) Yan Liao et al.   Scientific Reports

Generation of phospho-ubiquitin variants by orthogonal translation reveals codon skipping

(2016) Susanna George et al.   FEBS LETTERS

Inhibition of the PI3K/AKT/mTOR Pathway in Solid Tumors

(2016) Patricia Mucci LoRusso   JOURNAL OF CLINICAL ONCOLOGY

SEMA3B improves the survival of patients with esophageal squamous cell carcinoma by upregulating p53 and p21

(2016) Hong Tang et al.   ONCOLOGY REPORTS

Plasma 25-Hydroxyvitamin D Is Related to Protein Signaling Involved in Glucose Homeostasis in a Tissue-Specific Manner

(2016) Lewan Parker et al.   Nutrients

Up-Regulation of Voltage Gated K+ Channels Kv1.3 and Kv1.5 by Protein Kinase PKB/Akt

(2015) Jamshed Warsi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Phosphorylation of AKT: a Mutational Analysis.

(2015) Jonathan R. Hart et al.   Oncotarget

PI3K/AKT signaling pathway and cancer: an updated review

(2014) Miriam Martini et al.   ANNALS OF MEDICINE

Turning Off AKT: PHLPP as a Drug Target

(2014) Alexandra C. Newton et al.   Annual Review of Pharmacology and Toxicology

Tuning the signalling output of protein kinase C

(2014) Corina E. Antal et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Kinase Regulation by Hydrophobic Spine Assembly in Cancer

(2014) Jiancheng Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

(2014) Pengda Liu et al.   NATURE

A Facile Strategy for Selective Incorporation of Phosphoserine into Histones

(2013) Sangsik Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Spatiotemporal Dynamics of Phosphorylation in Lipid Second Messenger Signaling

(2013) Corina E. Antal et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification and Quantification of AKT Isoforms and Phosphoforms in Breast Cancer Using a Novel Nanofluidic Immunoassay

(2013) Demetris C. Iacovides et al.   MOLECULAR & CELLULAR PROTEOMICS

CSTP1, a Novel Protein Phosphatase, Blocks Cell Cycle, Promotes Cell Apoptosis, and Suppresses Tumor Growth of Bladder Cancer by Directly Dephosphorylating Akt at Ser473 Site

(2013) De-Xiang Zhuo et al.   PLoS One

Targeting the PI3-Kinase/Akt/mTOR Signaling Pathway

(2013) Burhan Hassan et al.   Surgical Oncology Clinics of North America

Structural Basis for the Regulation of Protein Kinase A by Activation Loop Phosphorylation

(2012) Jon M. Steichen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Up-Regulation of the Inwardly Rectifying K+ Channel Kir2.1 (KCNJ2) by Protein Kinase B (PKB/Akt) and PIKfyve

(2012) Carlos Munoz et al.   JOURNAL OF MEMBRANE BIOLOGY

Why nature chose phosphate to modify proteins

(2012) T. Hunter   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer

(2011) E E Vincent et al.   BRITISH JOURNAL OF CANCER

A Mechanism for the Evolution of Phosphorylation Sites

(2011) Samuel M. Pearlman et al.   CELL

Expanding the Genetic Code of Escherichia coli with Phosphoserine

(2011) H.-S. Park et al.   SCIENCE

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

(2010) N Berndt et al.   CELL DEATH AND DIFFERENTIATION

Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies

(2009) Oded Edelheit et al.   BMC BIOTECHNOLOGY

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia

(2009) N Gallay et al.   LEUKEMIA

Synthesis and structure based optimization of novel Akt inhibitors

(2008) Blaise Lippa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS