An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

Data transformation practices in biomedical sciences

(2011) Mihai Valcu et al.   NATURE METHODS

A Mosaic Activating Mutation inAKT1Associated with the Proteus Syndrome

(2011) Marjorie J. Lindhurst et al.   NEW ENGLAND JOURNAL OF MEDICINE

Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity

(2011) T. O. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

(2010) Josef R. Bencsik et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of pyrrolopyrimidine inhibitors of Akt

(2010) James F. Blake et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo

(2010) Craig Cherrin et al.   CANCER BIOLOGY & THERAPY

Akt inhibitors in clinical development for the treatment of cancer

(2010) Sumanta Kumar Pal et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer

(2010) Daniel P. Sutherlin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

(2010) Wen-I Wu et al.   PLoS One

A Transition Path Ensemble Study Reveals a Linchpin Role for Mg2+during Rate-Limiting ADP Release from Protein Kinase A

(2009) Ilja V. Khavrutskii et al.   BIOCHEMISTRY

Inhibitor hijacking of Akt activation

(2009) Tatsuya Okuzumi et al.   Nature Chemical Biology

Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model

(2008) Mark T. Bilodeau et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

(2008) N. Rhodes et al.   CANCER RESEARCH

Use of Akt Inhibitor and a Drug-resistant Mutant Validates a Critical Role for Protein Kinase B/Akt in the Insulin-dependent Regulation of Glucose and System A Amino Acid Uptake

(2008) Charlotte J. Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY