The retinal pigment epithelium: Development, injury responses, and regenerative potential in mammalian and non-mammalian systems

Müller Glia-Mediated Retinal Regeneration

(2021) Hui Gao et al.   MOLECULAR NEUROBIOLOGY

Retinal Pigment Epithelium Replacement Therapy for Age-Related Macular Degeneration: Are We There Yet?

(2020) Ruchi Sharma et al.   Annual Review of Pharmacology and Toxicology

Inflammation and matrix metalloproteinase 9 (Mmp‐9) regulate photoreceptor regeneration in adult zebrafish

(2020) Nicholas J. Silva et al.   GLIA

The cell biology of the retinal pigment epithelium

(2020) Aparna Lakkaraju et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Inflammatory and Fibrogenic Factors in Proliferative Vitreoretinopathy Development

(2020) Rishika Chaudhary et al.   Translational Vision Science & Technology

FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency

(2020) Majid Mossahebi-Mohammadi et al.   Frontiers in Cell and Developmental Biology

Age-related macular degeneration therapy

(2020) Michael J. Ammar et al.   CURRENT OPINION IN OPHTHALMOLOGY

Regeneration Through in vivo Cell Fate Reprogramming for Neural Repair

(2020) Wenjiao Tai et al.   Frontiers in Cellular Neuroscience

Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O2-Rich Pigment Epithelium

(2020) Celia M. Bisbach et al.   Cell Reports

Epigenomic and Transcriptomic Changes During Human RPE EMT in a Stem Cell Model of Epiretinal Membrane Pathogenesis and Prevention by Nicotinamide

(2020) Nathan C. Boles et al.   Stem Cell Reports

Reprogramming Müller Glia to Regenerate Retinal Neurons

(2020) Manuela Lahne et al.   Annual Review of Vision Science

EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration

(2020) Daisy Y. Shu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RNA sequencing analysis of the human retina and associated ocular tissues

(2020) Scott T. Schumacker et al.   Scientific Data

Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Dysfunction

(2020) Mi Zhou et al.   Frontiers in Cell and Developmental Biology

Perspectives on somatic reprogramming: spotlighting epigenetic regulation and cellular heterogeneity

(2020) Jiekai Chen   CURRENT OPINION IN GENETICS & DEVELOPMENT

Update on Müller glia regenerative potential for retinal repair

(2020) Diana García-García et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The microRNAs miR-302d and miR-93 inhibit TGFB-mediated EMT and VEGFA secretion from ARPE-19 cells

(2020) Heiko R. Fuchs et al.   EXPERIMENTAL EYE RESEARCH

Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation

(2019) Nicholas J. Hanovice et al.   PLoS Genetics

Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration

(2019) Emily G. O’Koren et al.   IMMUNITY

Ocular gene therapies in clinical practice: viral vectors and nonviral alternatives

(2019) Thierry Bordet et al.   DRUG DISCOVERY TODAY

The transcription factor MITF in RPE function and dysfunction

(2019) Xiaoyin Ma et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Dissecting the transcriptome landscape of the human fetal neural retina and retinal pigment epithelium by single-cell RNA-seq analysis

(2019) Yuqiong Hu et al.   PLOS BIOLOGY

Subretinal Transplantation of Human Central Nervous System Stem Cells Stimulates Controlled Proliferation of Endogenous Retinal Pigment Epithelium

(2019) Trevor J. McGill et al.   Translational Vision Science & Technology

Microglia in Retinal Degeneration

(2019) Khalid Rashid et al.   Frontiers in Immunology

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration

(2019) Andrew P. Voigt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development

(2018) Kyeong Hwan Moon et al.   DEVELOPMENTAL CELL

Necroptosis: a regulated inflammatory mode of cell death

(2018) Yogesh K. Dhuriya et al.   Journal of Neuroinflammation

Complement factor H in AMD: Bridging genetic associations and pathobiology

(2018) Christopher B. Toomey et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Neural retina-specific Aldh1a1 controls dorsal choroidal vascular development via Sox9 expression in retinal pigment epithelial cells

(2018) So Goto et al.   eLife

Modulation of three key innate immune pathways for the most common retinal degenerative diseases

(2018) Isha Akhtar‐Schäfer et al.   EMBO Molecular Medicine

Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas

(2018) Kai Yao et al.   NATURE

Metabolic signature of the aging eye in mice

(2018) Yekai Wang et al.   NEUROBIOLOGY OF AGING

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immune regulation in the aging retina

(2018) Mei Chen et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Potentials of Cellular Reprogramming as a Novel Strategy for Neuroregeneration

(2018) Lyujie Fang et al.   Frontiers in Cellular Neuroscience

Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic Target

(2018) Ilaria Bellezza   Frontiers in Pharmacology

In situ regeneration of retinal pigment epithelium by gene transfer of E2F2: a potential strategy for treatment of macular degenerations

(2017) D Kampik et al.   GENE THERAPY

Different distributions of M1 and M2 macrophages in a mouse model of laser-induced choroidal neovascularization

(2017) Yedi Zhou et al.   Molecular Medicine Reports

Stimulation of functional neuronal regeneration from Müller glia in adult mice

(2017) Nikolas L. Jorstad et al.   NATURE

Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina

(2017) David T. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD

(2017) Sayantan Datta et al.   PROGRESS IN RETINAL AND EYE RESEARCH

On phagocytes and macular degeneration

(2017) Xavier Guillonneau et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Noninvasive near infrared autofluorescence imaging of retinal pigment epithelial cells in the human retina using adaptive optics

(2017) Tao Liu et al.   Biomedical Optics Express

Report on the National Eye Institute Audacious Goals Initiative: Replacement of Retinal Ganglion Cells from Endogenous Cell Sources

(2017) Monica L. Vetter et al.   Translational Vision Science & Technology

Retinal pigment epithelial cell multinucleation in the aging eye - a mechanism to repair damage and maintain homoeostasis

(2016) Mei Chen et al.   AGING CELL

In Vivo Cellular Reprogramming: The Next Generation

(2016) Deepak Srivastava et al.   CELL

Retina regeneration in zebrafish

(2016) Jin Wan et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Retinal regeneration in birds and mice

(2016) Matthew S Wilken et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye

(2016) Jin Young Kim et al.   DEVELOPMENTAL BIOLOGY

Interferon‐beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization

(2016) Anika Lückoff et al.   EMBO Molecular Medicine

Role of epithelial–mesenchymal transition in proliferative vitreoretinopathy

(2016) Shigeo Tamiya et al.   EXPERIMENTAL EYE RESEARCH

Mitochondrial elongation in the macular RPE of aging monkeys, evidence of metabolic stress

(2016) Peter Gouras et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Inflammasome priming increases retinal pigment epithelial cell susceptibility to lipofuscin phototoxicity by changing the cell death mechanism from apoptosis to pyroptosis

(2016) Carolina Brandstetter et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are Associated with the Upregulation of Wingless-Related Integration and Bone Morphogenetic Protein Signaling in Dark Agouti Rats

(2016) Heba Al-Hussaini et al.   MEDICAL PRINCIPLES AND PRACTICE

Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes

(2016) Kamron N. Khan et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Multi-nucleate retinal pigment epithelium cells of the human macula exhibit a characteristic and highly specific distribution

(2016) AUSTIN C. STARNES et al.   VISUAL NEUROSCIENCE

FGF Signaling Is Required for Lens Regeneration in Xenopus laevis

(2016) Lisa Fukui et al.   BIOLOGICAL BULLETIN

Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis

(2016) Jian Liu et al.   Scientific Reports

Turning the fate of reprogramming cells from retinal disorder to regeneration by Pax6 in newts

(2016) Martin Miguel Casco-Robles et al.   Scientific Reports

TGF-β2 secretion from RPE decreases with polarization and becomes apically oriented

(2015) Louis Hirsch et al.   CYTOKINE

Yap and Taz regulate retinal pigment epithelial cell fate

(2015) J. B. Miesfeld et al.   DEVELOPMENT

Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo

(2015) R. Reinhardt et al.   EMBO JOURNAL

Retinal pigment epithelial cell proliferation

(2015) Jeffrey Stern et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells

(2015) Makoto Ishikawa et al.   EXPERIMENTAL EYE RESEARCH

CRALBP supports the mammalian retinal visual cycle and cone vision

(2015) Yunlu Xue et al.   JOURNAL OF CLINICAL INVESTIGATION

Assessment of retinal pigment epithelial cells in epiretinal membrane formation

(2015) Lei-Chi Wang et al.   Journal of the Chinese Medical Association

Transgenic expression of the proneural transcription factor Ascl1 in Müller glia stimulates retinal regeneration in young mice

(2015) Yumi Ueki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinal microglia: Just bystander or target for therapy?

(2015) Marcus Karlstetter et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Stem cell based therapies for age-related macular degeneration: The promises and the challenges

(2015) Hossein Nazari et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Concise Review: Making Stem Cells Retinal: Methods for Deriving Retinal Pigment Epithelium and Implications for Patients With Ocular Disease

(2015) Lyndsay L. Leach et al.   STEM CELLS

Scotopic and Photopic Microperimetry in Patients With Reticular Drusen and Age-Related Macular Degeneration

(2015) Julia S. Steinberg et al.   JAMA Ophthalmology

Death-Defining Immune Responses After Apoptosis

(2014) L. Campisi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

(2014) Sayak K Mitter et al.   Autophagy

Reprogramming of the chick retinal pigmented epithelium after retinal injury

(2014) Agustin Luz-Madrigal et al.   BMC BIOLOGY

Immune Modulation of Stem Cells and Regeneration

(2014) Arin B. Aurora et al.   Cell Stem Cell

Dose-Dependent Retinal Changes Following Sodium Iodate Administration: Application of Spectral-Domain Optical Coherence Tomography for Monitoring of Retinal Injury and Endogenous Regeneration

(2014) Anna Machalińska et al.   CURRENT EYE RESEARCH

Perspectives on antigen presenting cells in zebrafish

(2014) Kanako L. Lewis et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Retinal stem/progenitor cells in the ciliary marginal zone complete retinal regeneration: A study of retinal regeneration in a novel animal model

(2014) Ayumi Miyake et al.   Developmental Neurobiology

Zebrafish as a model for understanding the evolution of the vertebrate immune system and human primary immunodeficiency

(2014) Norimasa Iwanami   EXPERIMENTAL HEMATOLOGY

Müller glial cell reprogramming and retina regeneration

(2014) Daniel Goldman   NATURE REVIEWS NEUROSCIENCE

A Transcriptome for the Study of Early Processes of Retinal Regeneration in the Adult Newt, Cynops pyrrhogaster

(2014) Kenta Nakamura et al.   PLoS One

Trophic factors in the pathogenesis and therapy for retinal degenerative diseases

(2014) Anton M. Kolomeyer et al.   SURVEY OF OPHTHALMOLOGY

The newt reprograms mature RPE cells into a unique multipotent state for retinal regeneration

(2014) Md. Rafiqul Islam et al.   Scientific Reports

Retinal Injury, Growth Factors, and Cytokines Converge on β-Catenin and pStat3 Signaling to Stimulate Retina Regeneration

(2014) Jin Wan et al.   Cell Reports

Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis

(2014) Wan Ling Wong et al.   Lancet Global Health

Sustained ERK Activation Underlies Reprogramming in Regeneration-Competent Salamander Cells and Distinguishes Them from Their Mammalian Counterparts

(2014) Maximina H. Yun et al.   Stem Cell Reports

RPE specification in the chick is mediated by surface ectoderm-derived BMP and Wnt signalling

(2013) J. Steinfeld et al.   DEVELOPMENT

ASCL1 reprograms mouse Muller glia into neurogenic retinal progenitors

(2013) J. Pollak et al.   DEVELOPMENT

CCR2+monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation inCx3cr1deficient mice

(2013) Florian Sennlaub et al.   EMBO Molecular Medicine

Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin

(2013) Kentaro Hirose et al.   Epigenetics

The retinal pigment epithelium: An important player of retinal disorders and regeneration

(2013) Chikafumi Chiba   EXPERIMENTAL EYE RESEARCH

Retinal pigment epithelium development, plasticity, and tissue homeostasis

(2013) Sabine Fuhrmann et al.   EXPERIMENTAL EYE RESEARCH

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Loss of cell-extracellular matrix interaction triggers retinal regeneration accompanied byRaxandPax6Activation

(2013) Ayaka Nabeshima et al.   GENESIS

Directional protein secretion by the retinal pigment epithelium: roles in retinal health and the development of age-related macular degeneration

(2013) Paul Kay et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Changes in the Inflammatory Response to Injury and Its Resolution during the Loss of Regenerative Capacity in Developing Xenopus Limbs

(2013) Anthony L. Mescher et al.   PLoS One

Analysis of DNA methylation reveals a partial reprogramming of the Muller glia genome during retina regeneration

(2013) C. Powell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging is not a disease: Distinguishing age-related macular degeneration from aging

(2013) Daniel Ardeljan et al.   PROGRESS IN RETINAL AND EYE RESEARCH

SUBRETINAL DRUSENOID DEPOSITS WITH INCREASED AUTOFLUORESCENCE IN EYES WITH RETICULAR PSEUDODRUSEN

(2013) Mee Yon Lee et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Lens and retina regeneration: new perspectives from model organisms

(2012) Karla Barbosa-Sabanero et al.   BIOCHEMICAL JOURNAL

Adult Human RPE Can Be Activated into a Multipotent Stem Cell that Produces Mesenchymal Derivatives

(2012) Enrique Salero et al.   Cell Stem Cell

Transplantation of human central nervous system stem cells - neuroprotection in retinal degeneration

(2012) Trevor J. McGill et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pathological consequences of long-term mitochondrial oxidative stress in the mouse retinal pigment epithelium

(2012) Soo-jung Seo et al.   EXPERIMENTAL EYE RESEARCH

Age-related macular degeneration

(2012) Laurence S Lim et al.   LANCET

MEK–ERK signaling in adult newt retinal pigment epithelium cells is strengthened immediately after surgical induction of retinal regeneration

(2012) Aki Mizuno et al.   NEUROSCIENCE LETTERS

MITF-M, a ‘melanocyte-specific’ isoform, is expressed in the adult retinal pigment epithelium

(2012) Julien Maruotti et al.   Pigment Cell & Melanoma Research

Age-Related Changes in the Retinal Pigment Epithelium (RPE)

(2012) Xiaorong Gu et al.   PLoS One

Otx but Not Mitf Transcription Factors Are Required for Zebrafish Retinal Pigment Epithelium Development

(2012) Brandon M. Lane et al.   PLoS One

Wnt Signaling and Injury Repair

(2012) J. L. Whyte et al.   Cold Spring Harbor Perspectives in Biology

A Regulatory Loop Involving PAX6, MITF, and WNT Signaling Controls Retinal Pigment Epithelium Development

(2012) Kapil Bharti et al.   PLoS Genetics

A complex choreography of cell movements shapes the vertebrate eye

(2011) K. M. Kwan et al.   DEVELOPMENT

The Retinal Homeobox (Rx) gene is necessary for retinal regeneration

(2011) Reyna I. Martinez-De Luna et al.   DEVELOPMENTAL BIOLOGY

Embryonic expression of zebrafish MiT family genes tfe3b, tfeb, and tfec

(2011) James A. Lister et al.   DEVELOPMENTAL DYNAMICS

Enhanced retinal pigment epithelium regeneration after injury in MRL/MpJ mice

(2011) Huiming Xia et al.   EXPERIMENTAL EYE RESEARCH

FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish

(2011) Zhao Qin et al.   EXPERIMENTAL EYE RESEARCH

MEK-ERK and heparin-susceptible signaling pathways are involved in cell-cycle entry of the wound edge retinal pigment epithelium cells in the adult newt

(2011) Taro Yoshikawa et al.   Pigment Cell & Melanoma Research

Mature Peripheral RPE Cells Have an Intrinsic Capacity to Proliferate; A Potential Regulatory Mechanism for Age-Related Cell Loss

(2011) Ioannis Kokkinopoulos et al.   PLoS One

Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration

(2011) J.-D. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generating retinal neurons by reprogramming retinal pigment epithelial cells

(2010) Shu-Zhen Wang et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Transcriptome analysis and molecular signature of human retinal pigment epithelium

(2010) N.V. Strunnikova et al.   HUMAN MOLECULAR GENETICS

Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1

(2010) Sören Mai et al.   JOURNAL OF CELL SCIENCE

Sodium Iodate Selectively Injuries the Posterior Pole of the Retina in a Dose-Dependent Manner: Morphological and Electrophysiological Study

(2010) Anna Machalińska et al.   NEUROCHEMICAL RESEARCH

Animal models of choroidal and retinal neovascularization

(2010) Hans E. Grossniklaus et al.   PROGRESS IN RETINAL AND EYE RESEARCH

A RANDOMIZED PILOT STUDY OF SYSTEMIC IMMUNOSUPPRESSION IN THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION WITH CHOROIDAL NEOVASCULARIZATION

(2010) Robert B Nussenblatt et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Regenerative medicine for retinal diseases: activating endogenous repair mechanisms

(2010) M.O. Karl et al.   TRENDS IN MOLECULAR MEDICINE

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Shaping the vertebrate eye

(2009) Juan Ramon Martinez-Morales et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

 -catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression

(2009) P. Westenskow et al.   DEVELOPMENT

Lhx2 links the intrinsic and extrinsic factors that control optic cup formation

(2009) S. Yun et al.   DEVELOPMENT

Suppression of the immune response potentiates tadpole tail regeneration during the refractory period

(2009) T. Fukazawa et al.   DEVELOPMENT

Spatial and temporal regulation of Wnt/β-catenin signaling is essential for development of the retinal pigment epithelium

(2009) Naoko Fujimura et al.   DEVELOPMENTAL BIOLOGY

Comparative and developmental study of the immune system inXenopus

(2009) Jacques Robert et al.   DEVELOPMENTAL DYNAMICS

Complete reconstruction of the retinal laminar structure from a cultured retinal pigment epithelium is triggered by altered tissue interaction and promoted by overlaid extracellular matrices

(2009) Fusako Kuriyama et al.   Developmental Neurobiology

Amyloid-β up-regulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: Another mechanism of complement activation in age-related macular degeneration

(2009) Jiying Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris

(2009) M. Saint-Geniez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors

(2009) R. Longbottom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dynamic nature of Bruch's membrane

(2009) J.C. Booij et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Mechanism and Regulation of Class Switch Recombination

(2008) Janet Stavnezer et al.   Annual Review of Immunology

Dual requirement for Pax6 in retinal progenitor cells

(2008) V. Oron-Karni et al.   DEVELOPMENT

Zeb1 links epithelial-mesenchymal transition and cellular senescence

(2008) Y. Liu et al.   DEVELOPMENT

Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF

(2008) K. Bharti et al.   DEVELOPMENT

Immunohistochemical analysis of Musashi-1 expression during retinal regeneration of adult newt

(2008) Jun Kaneko et al.   NEUROSCIENCE LETTERS

Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice

(2007) Heping Xu et al.   AGING CELL

Activin signaling limits the competence for retinal regeneration from the pigmented epithelium

(2007) Sanae Sakami et al.   MECHANISMS OF DEVELOPMENT