Article
Anatomy & Morphology
Sohair A. Eltony, Heba S. Mohaseb, Amel A. Ahmed, Manal M. Sayed
Summary: This study aimed to investigate the effect of metformin on the retina of the ENU-induced rat model of RP. The results showed that metformin could reduce retinal degeneration and improve the morphology of glia and blood capillaries. This suggests that metformin has a neuroprotective effect on the retina.
Article
Ophthalmology
Alireza Badiei, William A. Beltran, Gustavo D. Aguirre
Summary: This study compared the expression levels of genes and proteins involved in retinal degeneration in normal dogs and canine models of inherited retinal degeneration. The results showed increased levels of H2S and NO in affected retinas, making cells vulnerable to oxidative damage and apoptosis.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Physiology
Joshua A. Chu-Tan, Adrian V. Cioanca, Yvette Wooff, Max Kirkby, Marissa Ellis, Pranay Gulati, Tim Karl, Jeffrey H. Boatright, Katie Bales, John Nickerson, Riccardo Natoli
Summary: This study investigates the cellular changes underlying exercise-induced retinal protection and suggests that exercise may slow the progression of retinal degenerations by modulating inflammatory pathways and shifting the transcriptomic profile to a healthy phenotype.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Ophthalmology
Marina Yasvoina, Qian Yang, Sasha M. Woods, Tjebo Heeren, Grant M. Comer, Catherine A. Egan, Marcus Fruttiger
Summary: This study found that RPE cells invading the retina in retinal degenerative diseases undergo dedifferentiation and can be pigmented or unpigmented. As a result, the number of these cells may be underestimated through funduscopy.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Yuhong Chen, Jieqiong Chen, Hong Wang, Yang Yu, Wenqiu Wang, Wenjia Liu, Suqin Yu, Yuanyuan Gong, Huixun Jia, Tong Li, Xiaodong Sun
Summary: The prevalence of outer retinal tubulation (ORT) varies among different inherited retinal diseases (IRDs) phenotypes, with the highest prevalence in Bietti crystalline corneoretinal dystrophy (BCD). The presence of choroidal atrophy and inner nuclear layer (INL) cysts may be associated with an increased risk of ORT formation in patients with IRD.
Review
Biochemistry & Molecular Biology
Geetika Kaur, Nikhlesh K. Singh
Summary: Retinal neurodegeneration, commonly manifested as apoptosis or impaired function of photoreceptors, is a major cause of irreversible vision loss and blindness. This review summarizes the extensive research conducted on the pathogenesis and treatment of retinal degenerative diseases, including age-related macular degeneration, inherited retinal dystrophies, retinitis pigmentosa, Stargardt macular dystrophy, and Leber congenital amaurosis. The role of inflammation in retinal degeneration is highlighted, and various therapeutic approaches, such as gene therapy and stem cell-based therapies, are evaluated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hanhan Wu, Beijing Zhu, Daijin Li, Jing Xu, Jie Chang, Xiaoye Du, Jingang Cui, Ning Zhang, Teng Zhang, Yu Chen
Summary: This study demonstrates for the first time that Cuscuta chinensis Lam. (CCL) has protective effects on photoreceptors, alleviating the damage caused by photooxidative stress to retinal structure and function, and maintaining immune homeostasis. These findings provide novel evidence supporting the clinical application of CCL in the prevention and treatment of photoreceptor degenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yiyi Chen, Yujie Dong, Jie Yan, Lan Wang, Shirley Yu, Kangwei Jiao, Francois Paquet-Durand
Summary: This study systematically mapped the transcriptional changes that occur in the degenerating mouse retina at the single cell level using single-cell RNA-sequencing. The results highlight the relevance of Ca2+-signaling and metabolic pathways to hereditary photoreceptor degeneration, and suggest that metabolic changes in rd1 mutation may be regulated through the MAPK pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Geetika Kaur, Nikhlesh K. Singh
Summary: Vision depends on the precise structure and functioning of the retina, and any stress or injury can disrupt it, leading to vision impairment, loss, and blindness. Inflammation plays a crucial role in the development of retinal disorders, such as glaucoma, macular degeneration, diabetic retinopathy, and retinitis pigmentosa. This review provides evidence on the role of inflammation in these disorders and suggests potential therapeutic targets.
NEURAL REGENERATION RESEARCH
(2023)
Review
Nutrition & Dietetics
Arun J. J. Thirunavukarasu, A. Catharine Ross, Rose M. M. Gilbert
Summary: Vitamin A plays critical roles in body systems, including the immune system and the eyes. Deficiency of vitamin A can lead to impaired immune function and ocular disorders. Degenerative eye conditions such as Stargardt's disease and age-related macular degeneration are influenced by vitamin A.
FRONTIERS IN NUTRITION
(2022)
Review
Ophthalmology
Malena Daich Varela, Tassos Georgiadis, Michel Michaelides
Summary: Inherited retinal diseases (IRDs) have been a significant area of gene therapy development in the past decade, with over 40 clinical trials completed or ongoing. Recently, there has been progress in targeting autosomal dominant diseases, such as retinitis pigmentosa, using novel therapeutic approaches like antisense oligonucleotide therapy. Autosomal dominant IRDs are less common but tend to have milder symptoms and later onset compared to autosomal recessive diseases. Various strategies, including zinc fingers, RNA interference, antisense oligonucleotides, translational read-through therapy, and gene editing, are currently being investigated for their potential in treating IRDs.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jie Yan, Alexander Guenter, Soumyaparna Das, Regine Muehlfriedel, Stylianos Michalakis, Kangwei Jiao, Mathias W. Seeliger, Francois Paquet-Durand
Summary: Inherited retinal degenerations (IRDs) are blinding diseases characterized by progressive loss of photoreceptors. The excessive activation of calpain and poly (ADP-ribose) polymerase (PARP) is associated with the pathology of IRDs. Inhibitors of these enzymes have shown promise in preventing photoreceptor cell death. However, the relationship between calpain and PARP in IRDs is still unclear. In this study, organotypic retinal explant cultures were used to investigate the effects of calpain inhibitors, PARP inhibitors, and voltage-gated Ca2+ channel (VGCC) inhibitors on cell death in IRD mice models. The results suggest that PARP acts upstream of calpain and both enzymes are part of the same degenerative pathway in Pde6b-dependent photoreceptor degeneration. Our findings highlight the potential of targeting PARP for therapeutic interventions in IRD-type diseases.
Article
Pharmacology & Pharmacy
Akanksha Roy, Riet Hilhorst, John Groten, Francois Paquet-Durand, Tushar Tomar
Summary: Inherited retinal degenerative diseases are rare neurodegenerative disorders caused by mutations in hundreds of genes leading to vision loss. Gene-based therapies have shown promise as the first FDA-approved drug specifically targeting RPE65 mutation, but are mutation-dependent and may not be suitable for all patients. Further research is needed to identify common therapeutic targets and develop mutation-independent therapies.
CURRENT OPINION IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lacramioara Samoila, Oliviu Vostinaru, Elena Dinte, Andreea Elena Bodoki, Bogdan-Cezar Iacob, Ede Bodoki, Ovidiu Samoila
Summary: The topical administration of medicines for retinal degenerative diseases is limited by the eye's barriers, but NSAIDs have shown potential for effective treatment. Other drug classes may require fine-tuning of pharmacokinetic profiles or advanced formulation strategies for improved delivery to the retina. Ultimately, developing more effective ways of delivering drugs to the posterior eye will enhance clinical efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Qing Zhu, Xue Rui, Ya Li, Ya You, Xun-Lun Sheng, Bo Lei
Summary: The study aimed to describe the genetic and clinical features of 17 patients with ABCA4-related inherited retinal degenerations (IRDs) and define the phenotype-genotype correlations. Four novel ABCA4 variants were identified, expanding the spectrum of disease-causing variants in ABCA4 for future genetic counseling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Ophthalmology
Yaru Dong, Yu Sawada, Jizhe Cui, Masahiro Hayakawa, Dai Ogino, Makoto Ishikawa, Takeshi Yoshitomi
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2016)
Article
Neurosciences
Makoto Ishikawa, Takeshi Yoshitomi, Douglas F. Covey, Charles F. Zorumski, Yukitoshi Izumi
Article
Multidisciplinary Sciences
Yu Sawada, Masanori Hangai, Makoto Ishikawa, Takeshi Yoshitomi
Article
Ophthalmology
Yu Sawada, Makoto Araie, Makoto Ishikawa, Takeshi Yoshitomi
Article
Ophthalmology
Yu Sawada, Makoto Araie, Hitomi Kasuga, Makoto Ishikawa, Toyoto Iwata, Katsuyuki Murata, Takeshi Yoshitomi
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2018)
Article
Ophthalmology
Yu Sawada, Makoto Araie, Hitomi Shibata, Makoto Ishikawa, Toyoto Iwata, Takeshi Yoshitomi
Article
Multidisciplinary Sciences
Yu Sawada, Masanori Hangai, Makoto Ishikawa, Takeshi Yoshitomi
Article
Multidisciplinary Sciences
Makoto Ishikawa, Takeshi Yoshitomi, Charles F. Zorumski, Yukitoshi Izumi
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Makoto Ishikawa, Takeshi Yoshitomi, Douglas F. Covey, Charles F. Zorumski, Yukitoshi Izumi
SCIENTIFIC REPORTS
(2018)
Article
Cell Biology
Makoto Ishikawa, Sanae Takaseki, Takeshi Yoshitomi, Douglas F. Covey, Charles F. Zorumski, Yukitoshi Izumi
Summary: AlloP protects retinal ganglion cells through GABR/GABA(A) receptors in a rat glaucoma model. It induces a protective form of autophagy, preventing apoptosis and preserving RGCs in both ex vivo and in vivo models. AlloP shows potential as a therapeutic agent for glaucoma treatment.
Article
Ophthalmology
Rei Sakata, Takeshi Yoshitomi, Makoto Araie
Summary: The study showed that in otherwise healthy Japanese normal-tension glaucoma patients who received no treatment, the probability of disc haemorrhage occurrence was 31% at 5 years. Risk factors included lower myopic refraction, higher intraocular pressure during follow-up, and presence of disc haemorrhage at baseline.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Yu Sawada, Makoto Araie, Hitomi Shibata, Katsuyuki Murata, Makoto Ishikawa, Takeshi Yoshitomi, Takeshi Iwase
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Multidisciplinary Sciences
Akiko Futakuchi, Takeshi Morimoto, Yoko Ikeda, Hidenobu Tanihara, Toshihiro Inoue
SCIENTIFIC REPORTS
(2020)
Article
Ophthalmology
Hitomi Shibata, Yu Sawada, Makoto Ishikawa, Takeshi Yoshitomi, Takeshi Iwase
Summary: This study investigated peripapillary choroidal thickness (PPCT) in normal Japanese subjects using EDI SD-OCT. It found that older age and female sex were significantly associated with thinner global PPCT. These results may serve as a reference for assessing normal PPCT status, with consideration of age and sex of the subjects.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Yu Sawada, Makoto Araie, Hitomi Shibata, Makoto Ishikawa, Toyoto Iwata, Takeshi Yoshitomi
OPHTHALMOLOGY GLAUCOMA
(2019)
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)
