Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 118, Issue 17, Pages e2023130118
Publisher
Proceedings of the National Academy of Sciences
Online
2021-04-21
DOI
10.1073/pnas.2023130118
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Local Peroxynitrite Impairs Endothelial TRPV4 Channels and Elevates Blood Pressure in Obesity
- (2020) Matteo Ottolini et al. CIRCULATION
- Urgent reconsideration of lung edema as a preventable outcome in COVID-19: Inhibition of TRPV4 represents a promising and feasible approach
- (2020) Wolfgang Michael Kuebler et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Mechanisms underlying selective coupling of endothelial Ca 2+ signals with eNOS versus IK/SK channels in systemic and pulmonary arteries
- (2020) Matteo Ottolini et al. JOURNAL OF PHYSIOLOGY-LONDON
- Calcium signals that determine vascular resistance
- (2019) Matteo Ottolini et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration
- (2019) Daniel S. de Jesus et al. Redox Biology
- Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)–Dependent Pulmonary Arterial Hypertension
- (2019) Suellen D.S. Oliveira et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Reactive oxygen species induced Ca2+ influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension
- (2018) Karthik Suresh et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- TRPV4 (Transient Receptor Potential Vanilloid 4) Channel–Dependent Negative Feedback Mechanism Regulates GqProtein–Coupled Receptor–Induced VasoconstrictionHighlights
- (2018) Kwangseok Hong et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells
- (2018) Zhenlong Chen et al. MOLECULAR BIOLOGY OF THE CELL
- Pulmonary hypertension: the unaddressed global health burden
- (2018) Stuart Rich et al. Lancet Respiratory Medicine
- Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow
- (2017) Thomas A Longden et al. NATURE NEUROSCIENCE
- Contribution of reactive oxygen species to the pathogenesis of pulmonary arterial hypertension
- (2017) Nikki L. Jernigan et al. PLoS One
- Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4
- (2017) Mui Cheung et al. ACS Medicinal Chemistry Letters
- Genetic compensation: A phenomenon in search of mechanisms
- (2017) Mohamed A. El-Brolosy et al. PLoS Genetics
- Nitric Oxide–Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary Arteries
- (2017) Corina Marziano et al. Journal of the American Heart Association
- Elafin Reverses Pulmonary Hypertension via Caveolin-1–Dependent Bone Morphogenetic Protein Signaling
- (2015) Nils P. Nickel et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Nitric oxide synthase in innate and adaptive immunity: an update
- (2015) Christian Bogdan TRENDS IN IMMUNOLOGY
- Functional Coupling of TRPV4, IK, and SK Channels Contributes to Ca2+-Dependent Endothelial Injury in Rodent Lung
- (2015) Mike T. Lin et al. Pulmonary Circulation
- Flow shear stress enhances intracellular Ca2+ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension
- (2014) Shanshan Song et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension
- (2014) S. K. Sonkusare et al. Science Signaling
- Nitrosation-Dependent Caveolin 1 Phosphorylation, Ubiquitination, and Degradation and its Association with Idiopathic Pulmonary Arterial Hypertension
- (2014) Farnaz R. Bakhshi et al. Pulmonary Circulation
- The Sugen 5416/Hypoxia Mouse Model of Pulmonary Hypertension Revisited: Long-Term Follow-Up
- (2014) Sally H. Vitali et al. Pulmonary Circulation
- TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension
- (2013) Yang Xia et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Analysis of responses to the TRPV4 agonist GSK1016790A in the pulmonary vascular bed of the intact-chest rat
- (2013) Edward A. Pankey et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Nitric Oxide Deficiency and Endothelial Dysfunction in Pulmonary Arterial Hypertension
- (2013) James R. Klinger et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Pulmonary Hypertension Secondary to Left-Heart Failure Involves Peroxynitrite-Induced Downregulation of PTEN in the Lung
- (2013) Yazhini Ravi et al. HYPERTENSION
- Peroxynitrite, a Stealthy Biological Oxidant
- (2013) Rafael Radi JOURNAL OF BIOLOGICAL CHEMISTRY
- UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling
- (2013) Carlene Moore et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells
- (2012) Elodie Martin et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Elementary Ca2+ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function
- (2012) S. K. Sonkusare et al. SCIENCE
- An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure
- (2012) Kevin S. Thorneloe et al. Science Translational Medicine
- Thrombin-induced ATP release from human umbilical vein endothelial cells
- (2011) Stefanie Gödecke et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension
- (2011) Xiao-Ru Yang et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- TRPV4 channels augment macrophage activation and ventilator-induced lung injury
- (2010) Kazutoshi Hamanaka et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Tissue-derived proinflammatory effect of adenosine A2B receptor in lung ischemia–reperfusion injury
- (2010) Farshad Anvari et al. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
- TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress
- (2009) Suelhem A. Mendoza et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- NADPH Oxidase-1 Plays a Crucial Role in Hyperoxia-induced Acute Lung Injury in Mice
- (2009) Stéphanie Carnesecchi et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries
- (2009) I. Sorensen et al. BLOOD
- Activation of the TRPV4 Ion Channel Is Enhanced by Phosphorylation
- (2009) Hueng-Chuen Fan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration
- (2009) You-Yang Zhao et al. JOURNAL OF CLINICAL INVESTIGATION
- Increased pulmonary vascular resistance and defective pulmonary artery filling in caveolin-1−/− mice
- (2008) Nikolaos A. Maniatis et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Role of Caveolar Compartmentation in Endothelium-Derived Hyperpolarizing Factor–Mediated Relaxation
- (2008) J. Saliez et al. CIRCULATION
- Negative-Feedback Loop Attenuates Hydrostatic Lung Edema via a cGMP-Dependent Regulation of Transient Receptor Potential Vanilloid 4
- (2008) Jun Yin et al. CIRCULATION RESEARCH
- TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells
- (2008) I. M. Lorenzo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started