Article
Medicine, General & Internal
Makiko Nakamura, Teruhiko Imamura, Koichiro Kinugawa
Summary: This retrospective study evaluated consecutive patients who received vericiguat between September 2021 and December 2022, and the results suggest that vericiguat therapy may be feasible and effective upon quadruple therapy for patients with heart failure, although further investigation is needed to validate these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Physiology
Sahil Zaveri, Ujala Srivastava, Yongxia Sarah Qu, Mohamed Chahine, Mohamed Boutjdir
Summary: Ca2+ plays a crucial role in excitation-contraction coupling in cardiac myocytes, and dysfunctional Ca2+ regulation can lead to altered contraction force and cardiac arrhythmias. The entry of Ca2+ into cardiomyocytes is mainly mediated by L-type Ca2+ channels, with Ca(v)1.3 being implicated in sinoatrial and atrioventricular node dysfunction as well as atrial fibrillation. Understanding the functional and molecular pathways of Ca(v)1.3 in the heart may help develop targeted therapeutic interventions for these arrhythmias.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Steffen Blum, Stefanie Aeschbacher, Michael Coslovsky, Pascal B. Meyre, Philipp Reddiess, Peter Ammann, Paul Erne, Giorgio Moschovitis, Marcello Di Valentino, Dipen Shah, Juerg Schlaepfer, Rahel Mueller, Juerg H. Beer, Richard Kobza, Leo H. Bonati, Elisavet Moutzouri, Nicolas Rodondi, Christine Meyer-Zuern, Michael Kuehne, Christian Sticherling, Stefan Osswald, David Conen
Summary: This study aimed to investigate the association between types of atrial fibrillation (AF) and adverse outcomes. Through the follow-up of 3843 AF patients, it was found that the type of AF was not associated with the incidence of stroke or systemic embolism.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, Research & Experimental
Mohit Kumar, Md. Kamaruz Zaman, Sanghita Das, Danswrang Goyary, Manash Pratim Pathak, Pronobesh Chattopadhyay
Summary: Research on TRPV4 suggests that it plays an important role in maintaining respiratory homeostasis and is upregulated in life-threatening lung disorders. It is sensitive to various stimuli and interacts with different proteins and lipid mediators. Inhibiting TRPV4 could be a potential therapeutic approach for respiratory diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
M. A. ap Pfeffer, B. Claggett, E. F. Lewis, C. B. Granger, L. Kober, A. P. Maggioni, D. L. Mann, J. J. V. McMurray, J. -L. Rouleau, S. D. Solomon, P. G. Steg, O. Berwanger, M. Cikes, C. G. De Pasquale, C. East, A. Fernandez, K. Jering, U. Landmesser, R. Mehran, B. Merkely, F. Vaghaiwalla Mody, M. C. Petrie, I. Petrov, M. Schou, M. Senni, D. Sim, P. van der Meer, M. Lefkowitz, Y. Zhou, J. Gong, E. Braunwald
Summary: Among patients with acute myocardial infarction, the use of Sacubitril-Valsartan did not significantly reduce the incidence of death from cardiovascular causes or incident heart failure compared to ramipril.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Deborah M. Eaton, Thomas G. Martin, Michael Kasa, Natasa Djalinac, Senka Ljubojevic-Holzer, Dirk Von Lewinski, Maria Poettler, Theerachat Kampaengsri, Andreas Krumphuber, Katharina Scharer, Heinrich Maechler, Andreas Zirlik, Timothy A. McKinsey, Jonathan A. Kirk, Steven R. Houser, Peter P. Rainer, Markus Wallner
Summary: This study evaluated the effects of the pan-HDAC inhibitor SAHA on cardiac function in a heart failure model and found that SAHA can improve cardiomyocyte and contractile protein function by increasing myofilament calcium sensitivity and reducing diastolic tension.
Article
Physiology
Alessia Cacciotti, Chiara Pappalettera, Francesca Miraglia, Lavinia Valeriani, Elda Judica, Paolo Maria Rossini, Fabrizio Vecchio
Summary: The aim of this study was to analyze the effects of CHF on brain activity through EEG complexity measures. The results showed significant differences between CHF patients and healthy elderly individuals in the total spectrum and theta frequency band of the EEG. Within the CHF group, correlations were found between EEG parameters and clinical data such as BNP and NYHA scores. These findings suggest similarities between EEG abnormalities in CHF and cognitive impairment.
Article
Cardiac & Cardiovascular Systems
JoAnn Lindenfeld, Richa Gupta, Luanda Grazette, Jean Marie Ruddy, Lana Tsao, Elizabeth Galle, Tyson Rogers, Samuel Sears, Faiez Zannad
Summary: The study aimed to assess sex differences in the efficacy and safety of baroreflex activation therapy in heart failure patients. Women had poorer baseline quality of life than men but showed similar improvements with therapy. Women had a significant improvement in NT-proBNP levels, while men did not.
JACC-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Javed Butler, Milton Packer, Tariq Jamal Siddiqi, Michael Boehm, Martina Brueckmann, James L. Januzzi, Subodh Verma, Ingrid Gergei, Tomoko Iwata, Christoph Wanner, Joao Pedro Ferreira, Stuart J. Pocock, Gerasimos Filippatos, Stefan D. Anker, Faiez Zannad
Summary: This study aimed to evaluate the effect of empagliflozin on patients with chronic kidney disease. It was found through a pooled analysis of EMPEROR-Reduced and EMPEROR-Preserved that empagliflozin can reduce the risk of heart failure and heart failure-related death in patients with different risk categories.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Dongze Zhang, Huiyin Tu, Chaojun Wang, Liang Cao, Wenfeng Hu, Bryan T. Hackfort, Robert L. Muelleman, Michael C. Wadman, Yu-Long Li
Summary: Cardiac sympathetic overactivation is associated with ventricular arrhythmias in CHF patients; investigating the role of Cav2.2 channels in CHF revealed that transfection with Cav2.2-alpha shRNA reduced expression of Cav2.2-alpha mRNA and protein, decreasing neuronal currents and excitability, improving sympathetic nerve activity, and reducing ventricular arrhythmias.
CARDIOVASCULAR RESEARCH
(2021)
Article
Plant Sciences
Najeeb Ur Rehman, Mohd Nazam Ansari, Wasim Ahmad, Syed Rizwan Ahamad
Summary: The methanolic extract of Balanites aegyptiaca fruits shows potential medicinal value in treating hyperactive gut disorders by inhibiting diarrhea and spasms effectively.
Article
Chemistry, Medicinal
Brian G. Lawhorn, Edward J. Brnardic, David J. Behm
Summary: TRPV4 is a widely expressed ion channel that regulates cellular signaling and has potential therapeutic applications for various human diseases. Recent progress in the discovery of TRPV4 antagonists has shown efficacy in pre-clinical models, suggesting promise for potential clinical benefits in the future.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2021)
Article
Medical Laboratory Technology
Kian Keong Poh, Asim Shabbir, Jinghao Nicholas Ngiam, Poay Sian Sabrina Lee, Jimmy So, Christopher M. Frampton, Christopher J. Pemberton, Arthur M. Richards
Summary: This study suggests that obesity is associated with increased clearance but preserved bioactivity of BNP. In the postoperative study, plasma NP concentrations were relatively higher but not significantly, indicating a certain impact of obesity on the bioactivity of NPs.
CLINICAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Michael R. Zile, Maria Rosa R. Costanzo, Ekaterina M. Ippolito, Yan Zhang, Russell Stapleton, Ashish Sadhu, Javier Jimenez, Joe Hobbs, Vinod Sharma, Eduardo N. Warman, Lindsay Streeter, Javed Butler
Summary: The study aimed to determine the feasibility of implementing a heart failure management strategy using a device-based risk stratification model and standardized ambulatory medication intervention. The results support the testing of an ambulatory medication intervention strategy in a large randomized clinical trial based on individualized device risk stratification, physician-directed, and CHFN-implemented.
Article
Medicine, Research & Experimental
Ram Gelman, Noa Hurvitz, Rima Nesserat, Yotam Kolben, Dean Nachman, Khurram Jamil, Samuel Agus, Rabea Asleh, Offer Amir, Marc Berg, Yaron Ilan
Summary: This study utilized a second-generation artificial intelligence system to manage diuretic therapy for congestive heart failure patients. The personalized algorithm-controlled regimens significantly improved diuretic resistance, as well as various clinical indicators.
BIOMEDICINE & PHARMACOTHERAPY
(2023)