Intrinsic strategies for the evasion of cGAS-STING signaling-mediated immune surveillance in human cancer: How therapy can overcome them

Human Cancer Cells Sense Cytosolic Nucleic Acids Through the RIG-I–MAVS Pathway and cGAS–STING Pathway

(2021) Yuan Qiao et al.   Frontiers in Cell and Developmental Biology

Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

(2020) Yi Zhou et al.   IMMUNITY

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

(2020) Chun Zhou et al.   IMMUNITY

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

(2020) Chuanhui Han et al.   NATURE IMMUNOLOGY

Selective reactivation of STING signaling to target Merkel cell carcinoma

(2020) Wei Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LncRNA NEAT1 Interacted With DNMT1 to Regulate Malignant Phenotype of Cancer Cell and Cytotoxic T Cell Infiltration via Epigenetic Inhibition of p53, cGAS, and STING in Lung Cancer

(2020) Fang Ma et al.   Frontiers in Genetics

Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10

(2020) Cristina Bergamaschi et al.   Journal for ImmunoTherapy of Cancer

Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway

(2020) Xuewu Zhang et al.   IMMUNITY

Immunotherapies and Combination Strategies for Immuno-Oncology

(2020) Cody Barbari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

STEEP mediates STING ER exit and activation of signaling

(2020) Bao-cun Zhang et al.   NATURE IMMUNOLOGY

Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation

(2020) Chuan-xia Zhang et al.   Oncogenesis

The Age of Cyclic Dinucleotide Vaccine Adjuvants

(2020) Himanshu Gogoi et al.   Vaccines

Combination of Irreversible Electroporation and STING Agonist for Effective Cancer Immunotherapy

(2020) Eun-Jin Go et al.   Cancers

Low-dose carboplatin reprograms tumor immune microenvironment through STING signaling pathway and synergizes with PD-1 inhibitors in lung cancer

(2020) Li Zhou et al.   CANCER LETTERS

Promotion of TRAIL/Apo2L-induced apoptosis by low-dose interferon-β in human malignant melanoma cells

(2019) Akira Kazaana et al.   JOURNAL OF CELLULAR PHYSIOLOGY

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity

(2019) Jianwen Pei et al.   CANCER LETTERS

SLC19A1 Is an Importer of the Immunotransmitter cGAMP

(2019) Christopher Ritchie et al.   MOLECULAR CELL

Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity

(2019) Lifeng Li et al.   Molecular Cancer

HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity

(2019) Shiying Wu et al.   NATURE CELL BIOLOGY

STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade

(2019) Hannah Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

SLC19A1 transports immunoreactive cyclic dinucleotides

(2019) Rutger D. Luteijn et al.   NATURE

Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

(2019) Linda Schadt et al.   Cell Reports

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability

(2019) Christy Hong et al.   Cells

B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis

(2018) Alan Bénard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine

(2018) Yee Sun Tan et al.   CLINICAL CANCER RESEARCH

Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production

(2018) Hiroyasu Konno et al.   ONCOGENE

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment

(2018) Arunakumar Gangaplara et al.   PLoS Pathogens

Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies

(2018) Sandra Iurescia et al.   Frontiers in Immunology

STING agonist therapy in combination with PD-1 immune checkpoint blockade enhances response to carboplatin chemotherapy in high-grade serous ovarian cancer

(2018) Abdi Ghaffari et al.   BRITISH JOURNAL OF CANCER

HER2 activation factors in arsenite-exposed bladder epithelial cells

(2018) Peiyu Jin et al.   TOXICOLOGICAL SCIENCES

KDM5 histone demethylases repress immune response via suppression of STING

(2018) Lizhen Wu et al.   PLOS BIOLOGY

PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness

(2018) Jianfeng Shen et al.   CANCER RESEARCH

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

(2018) Assaf Marcus et al.   IMMUNITY

Ovarian Cancer Cells Commonly Exhibit Defective STING Signaling Which Affects Sensitivity to Viral Oncolysis

(2018) Nina Marí Gual Pimenta de Queiroz et al.   MOLECULAR CANCER RESEARCH

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

(2018) Shunsuke Kitajima et al.   Cancer Discovery

Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes

(2017) Silvia Cerboni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway

(2017) Yi-An Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-translational Control of Intracellular Pathogen Sensing Pathways

(2017) Cindy Chiang et al.   TRENDS IN IMMUNOLOGY

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway

(2017) Yi-An Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Decreased expression of STING predicts poor prognosis in patients with gastric cancer

(2017) Shushu Song et al.   Scientific Reports

Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis

(2016) Tianli Xia et al.   CANCER RESEARCH

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

(2016) Chih-Hang Anthony Tang et al.   CANCER RESEARCH

Growing tumors induce a local STING dependent Type I IFN response in dendritic cells

(2016) Lisa Andzinski et al.   INTERNATIONAL JOURNAL OF CANCER

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis

(2016) Filippos Kottakis et al.   NATURE

Decreased Expression of TMEM173 Predicts Poor Prognosis in Patients with Hepatocellular Carcinoma

(2016) Yang Bu et al.   PLoS One

Enhanced expression of long non-coding RNA NEAT1 is associated with the progression of gastric adenocarcinomas

(2016) Yanling Ma et al.   World Journal of Surgical Oncology

Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

(2016) Tianli Xia et al.   Cell Reports

Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors

(2015) J. R. Baird et al.   CANCER RESEARCH

Positive feedback regulation of type I interferon by the interferon-stimulated gene STING

(2015) F. Ma et al.   EMBO REPORTS

Cancer immunotherapy: harnessing the immune system to battle cancer

(2015) Yiping Yang   JOURNAL OF CLINICAL INVESTIGATION

Positive Feedback Regulation of Type I IFN Production by the IFN-Inducible DNA Sensor cGAS

(2015) Feng Ma et al.   JOURNAL OF IMMUNOLOGY

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

(2015) Olivier Demaria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

(2014) Soufiane Boumahdi et al.   NATURE

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

(2014) Lingyin Li et al.   Nature Chemical Biology

The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer

(2014) Dimple Chakravarty et al.   Nature Communications

Inflammation-driven carcinogenesis is mediated through STING

(2014) Jeonghyun Ahn et al.   Nature Communications

STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment

(2014) T. Ohkuri et al.   Cancer Immunology Research

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate

(2013) Abby Sarkar et al.   Cell Stem Cell

Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides

(2013) Guanghui Yi et al.   PLoS One

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Randomized Phase III Placebo-Controlled Trial of Carboplatin and Paclitaxel With or Without the Vascular Disrupting Agent Vadimezan (ASA404) in Advanced Non–Small-Cell Lung Cancer

(2011) Primo N. Lara et al.   JOURNAL OF CLINICAL ONCOLOGY

Type I IFNs Control Antigen Retention and Survival of CD8 + Dendritic Cells after Uptake of Tumor Apoptotic Cells Leading to Cross-Priming

(2011) S. Lorenzi et al.   JOURNAL OF IMMUNOLOGY

Type I interferons inhibit the generation of tumor-associated macrophages

(2009) Lance U’Ren et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

In vivo growth inhibition of head and neck squamous cell carcinoma by the Interferon-inducible gene IFI16

(2009) Jasenka Mazibrada et al.   CANCER LETTERS

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

(2008) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY