The Age of Cyclic Dinucleotide Vaccine Adjuvants

Pulmonary surfactant–biomimetic nanoparticles potentiate heterosubtypic influenza immunity

(2020) Ji Wang et al.   SCIENCE

Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H

(2020) Melissa M. Walker et al.   Frontiers in Immunology

T Cell Dysfunction and Exhaustion in Cancer

(2020) Zhen Zhang et al.   Frontiers in Cell and Developmental Biology

STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy

(2020) Esther N. Arwert et al.   NATURE CELL BIOLOGY

NK cells mediate clearance of CD8+ T cell–resistant tumors in response to STING agonists

(2020) Christopher J. Nicolai et al.   Science Immunology

STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets

(2020) Cameron S. Bader et al.   Science Translational Medicine

New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice

(2020) Himanshu Gogoi et al.   Frontiers in Immunology

Self-assembled cGAMP-STINGΔTM signaling complex as a bioinspired platform for cGAMP delivery

(2020) Yanpu He et al.   Science Advances

Obesity and STING1 genotype associate with 23-valent pneumococcal vaccination efficacy

(2020) Mathew Sebastian et al.   JCI Insight

Cyclic Dinucleotide–Adjuvanted Dengue Virus Nonstructural Protein 1 Induces Protective Antibody and T Cell Responses

(2019) Diego A. Espinosa et al.   JOURNAL OF IMMUNOLOGY

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and Qualitative Enhanced Immune Responses Post Immunization

(2019) Thomas Ebensen et al.   Frontiers in Cellular and Infection Microbiology

STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice

(2019) Ross J. Darling et al.   VACCINE

A microparticle platform for STING-targeted immunotherapy enhances natural killer cell- and CD8+ T cell-mediated anti-tumor immunity

(2019) Rebekah Watkins-Schulz et al.   BIOMATERIALS

STING pathway agonism as a cancer therapeutic

(2019) Blake A. Flood et al.   IMMUNOLOGICAL REVIEWS

Stimulator of Interferon Genes Agonists attenuate type I diabetes progression in NOD mice

(2019) Henrique Lemos et al.   IMMUNOLOGY

STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade

(2019) Hannah Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

The STING activator c-di-AMP exerts superior adjuvant properties than the formulation poly(I:C)/CpG after subcutaneous vaccination with soluble protein antigen or DEC-205-mediated antigen targeting to dendritic cells

(2019) Julia Volckmar et al.   VACCINE

An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases

(2019) Yang Liu et al.   Nature Communications

Combination of STING Pathway Agonist With Saponin Is an Effective Adjuvant in Immunosenescent Mice

(2019) Elena V. Vassilieva et al.   Frontiers in Immunology

STINGel: Controlled release of a cyclic dinucleotide for enhanced cancer immunotherapy

(2018) David G. Leach et al.   BIOMATERIALS

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

TMEM173 variants and potential importance to human biology and disease

(2018) Seema Patel et al.   GENES AND IMMUNITY

A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination

(2018) Robert D. Junkins et al.   JOURNAL OF CONTROLLED RELEASE

Multiple Homozygous Variants in the STING-EncodingTMEM173Gene in HIV Long-Term Nonprogressors

(2018) Sara K. Nissen et al.   JOURNAL OF IMMUNOLOGY

Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy

(2018) David R. Wilson et al.   Nanomedicine-Nanotechnology Biology and Medicine

Correlates of adjuvanticity: A review on adjuvants in licensed vaccines

(2018) Giuseppe Del Giudice et al.   SEMINARS IN IMMUNOLOGY

STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection

(2018) Erik Van Dis et al.   Cell Reports

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires’ disease in humans

(2018) Juan S. Ruiz-Moreno et al.   PLoS Pathogens

TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors

(2018) Brian J. Francica et al.   Cancer Immunology Research

Induction of necrotic cell death and activation of STING in the tumor microenvironment via cationic silica nanoparticles leading to enhanced antitumor immunity

(2018) Myunggi An et al.   Nanoscale

Systems analysis of human vaccine adjuvants

(2018) Ali M. Harandi   SEMINARS IN IMMUNOLOGY

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

(2018) Assaf Marcus et al.   IMMUNITY

Immature lung TNFR2− conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo

(2018) Samira Mansouri et al.   Mucosal Immunology

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

(2018) Kelsey E. Sivick et al.   Cell Reports

Response to Comment on “The Common R71H-G230A-R293Q HumanTMEM173Is a Null Allele”

(2017) Seema Patel et al.   JOURNAL OF IMMUNOLOGY

Innate Immune Activation by cGMP-AMP Nanoparticles Leads to Potent and Long-Acting Antiretroviral Response against HIV-1

(2017) Chukwuemika Aroh et al.   JOURNAL OF IMMUNOLOGY

Sublingual targeting of STING with 3′3′-cGAMP promotes systemic and mucosal immunity against anthrax toxins

(2017) Tara L. Martin et al.   VACCINE

Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway

(2017) Darío Lirussi et al.   EBioMedicine

Submicron-sized hydrogels incorporating cyclic dinucleotides for selective delivery and elevated cytokine release in macrophages

(2016) Eunjoo Lee et al.   Acta Biomaterialia

STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation

(2016) Henrique Lemos et al.   CANCER RESEARCH

Growing tumors induce a local STING dependent Type I IFN response in dendritic cells

(2016) Lisa Andzinski et al.   INTERNATIONAL JOURNAL OF CANCER

Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization

(2016) Rebecca Ball et al.   International Journal of Nanomedicine

The host STING pathway at the interface of cancer and immunity

(2016) Leticia Corrales et al.   JOURNAL OF CLINICAL INVESTIGATION

The Common R71H-G230A-R293Q HumanTMEM173Is a Null Allele

(2016) Seema Patel et al.   JOURNAL OF IMMUNOLOGY

STING Pathway Activation Stimulates Potent Immunity against Acute Myeloid Leukemia

(2016) Emily Curran et al.   Cell Reports

Safety of Nanoparticles in Medicine

(2015) Joy Wolfram et al.   CURRENT DRUG TARGETS

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

(2015) Melissa C. Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

(2015) Olivier Demaria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

(2015) Juan Fu et al.   Science Translational Medicine

T-cell exhaustion in the tumor microenvironment

(2015) Y Jiang et al.   Cell Death & Disease

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo

(2015) Steven M Blaauboer et al.   eLife

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Immunosenescence and vaccine failure in the elderly: Strategies for improving response

(2014) Diana Boraschi et al.   IMMUNOLOGY LETTERS

A new adjuvant delivery system ‘cyclic di-GMP/YSK05 liposome’ for cancer immunotherapy

(2014) Hiroko Miyabe et al.   JOURNAL OF CONTROLLED RELEASE

Activation of the STING Adaptor Attenuates Experimental Autoimmune Encephalitis

(2014) H. Lemos et al.   JOURNAL OF IMMUNOLOGY

DMXAA Causes Tumor Site-Specific Vascular Disruption in Murine Non-Small Cell Lung Cancer, and like the Endogenous Non-Canonical Cyclic Dinucleotide STING Agonist, 2′3′-cGAMP, Induces M2 Macrophage Repolarization

(2014) Charlene M. Downey et al.   PLoS One

Immunomodulatory activity of interferon-beta

(2014) Lloyd H. Kasper et al.   Annals of Clinical and Translational Neurology

Cutting Edge: DNA Sensing via the STING Adaptor in Myeloid Dendritic Cells Induces Potent Tolerogenic Responses

(2013) L. Huang et al.   JOURNAL OF IMMUNOLOGY

MPYS/STING-Mediated TNF- , Not Type I IFN, Is Essential for the Mucosal Adjuvant Activity of (3'-5')-Cyclic-Di-Guanosine-Monophosphate In Vivo

(2013) S. M. Blaauboer et al.   JOURNAL OF IMMUNOLOGY

Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides

(2013) Guanghui Yi et al.   PLoS One

Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities

(2012) Peter M. Gray et al.   CELLULAR IMMUNOLOGY

Identification and characterization of a loss-of-function human MPYS variant

(2011) L Jin et al.   GENES AND IMMUNITY

c-di-GMP protects against intranasal Acinetobacter baumannii infection in mice by chemokine induction and enhanced neutrophil recruitment

(2011) Lisa Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

(2011) L. Jin et al.   JOURNAL OF IMMUNOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Bis-(3′,5′)-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant

(2011) Thomas Ebensen et al.   VACCINE

Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice

(2011) Abdullah S. Madhun et al.   VACCINE

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

The member of the cyclic di-nucleotide family bis-(3′, 5′)-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant

(2010) Rimma Libanova et al.   VACCINE

The potential of 3′,5′-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant

(2010) Wangxue Chen et al.   VACCINE

3′,5′-Cyclic diguanylic acid elicits mucosal immunity against bacterial infection

(2009) Hongbin Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CD4+ T Cells and Immunosenescence – A Mini-Review

(2009) Alexander C. Maue et al.   GERONTOLOGY

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

(2009) Sarah M. McWhirter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

c-di-GMP as a vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection

(2009) Dong-Liang Hu et al.   VACCINE

Short- and long-term stability study of lyophilized solid lipid nanoparticles for gene therapy

(2008) A. del Pozo-Rodríguez et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection

(2008) Abiodun D. Ogunniyi et al.   VACCINE