Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression

Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression

(2020) Katarzyna A. Dudek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Wistar-Kyoto rat model of endogenous depression: A tool for exploring treatment resistance with an urgent need to focus on sex differences

(2020) Samuel J. Millard et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Liraglutide Attenuates Nonalcoholic Fatty Liver Disease by Modulating Gut Microbiota in Rats Administered a High-Fat Diet

(2020) Ningjing Zhang et al.   Biomed Research International

GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function

(2020) Katharina Timper et al.   Cell Metabolism

Neuroinflammation and depression: A review

(2020) Romain Troubat et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity

(2020) Aaron S. Kelly et al.   NEW ENGLAND JOURNAL OF MEDICINE

The supramammillary nucleus controls anxiety-like behavior; key role of GLP-1R

(2020) L. López-Ferreras et al.   PSYCHONEUROENDOCRINOLOGY

The Mechanism of Metabolic Influences on the Endogenous GLP-1 by Oral Antidiabetic Medications in Type 2 Diabetes Mellitus

(2020) Thiquynhnga Nguyen et al.   Journal of Diabetes Research

Clinical Evidence of Antidepressant Effects of Insulin and Anti-Hyperglycemic Agents and Implications for the Pathophysiology of Depression—A Literature Review

(2020) Young Sup Woo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Almond-Based Low Carbohydrate Diet Improves Depression and Glycometabolism in Patients with Type 2 Diabetes through Modulating Gut Microbiota and GLP-1: A Randomized Controlled Trial

(2020) Mengxiao Ren et al.   Nutrients

Alleviation of Depression by Glucagon-Like Peptide 1 Through the Regulation of Neuroinflammation, Neurotransmitters, Neurogenesis, and Synaptic Function

(2020) Young-Kook Kim et al.   Frontiers in Pharmacology

GLP-1 receptor signaling in the laterodorsal tegmental nucleus attenuates cocaine seeking by activating GABAergic circuits that project to the VTA

(2020) Nicole S. Hernandez et al.   MOLECULAR PSYCHIATRY

GLP-1R activation alters performance in cognitive tasks in a sex-dependent manner

(2020) Taylor S. Trammell et al.   NEUROLOGICAL SCIENCES

Impaired Brain Energy Metabolism: Involvement in Depression and Hypothyroidism

(2020) Katarzyna Głombik et al.   Frontiers in Neuroscience

Central GLP-1 receptors: Novel molecular targets for cocaine use disorder

(2019) N.S. Hernandez et al.   PHYSIOLOGY & BEHAVIOR

A systematic review of the antidepressant effects of glucagon-like peptide 1 (GLP-1) functional agonists: Further link between metabolism and psychopathology

(2019) Marco Pozzi et al.   JOURNAL OF AFFECTIVE DISORDERS

Metformin Promotes Anxiolytic and Antidepressant-Like Responses in Insulin-Resistant Mice by Decreasing Circulating Branched-Chain Amino Acids

(2019) Juliane Zemdegs et al.   JOURNAL OF NEUROSCIENCE

A review of the antimicrobial side of antidepressants and its putative implications on the gut microbiome

(2019) Abigail S McGovern et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Role of liraglutide in brain repair promotion through Sirt1‐mediated mitochondrial improvement in stroke

(2019) Weiliang He et al.   JOURNAL OF CELLULAR PHYSIOLOGY

GLP-1: Molecular mechanisms and outcomes of a complex signaling system

(2019) Nicholas K. Smith et al.   NEUROCHEMISTRY INTERNATIONAL

Glucagon-like peptide 1 (GLP-1)

(2019) T.D. Müller et al.   Molecular Metabolism

The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke

(2019) Yilong Shan et al.   Journal of Neuroinflammation

The Glucagon‐like peptide‐1 receptor agonist, exendin‐4, ameliorated gastrointestinal dysfunction in the Wistar Kyoto rat model of Irritable Bowel Syndrome

(2019) Rebecca O’Brien et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Brain Metabolic Alterations in Rats Showing Depression-Like and Obesity Phenotypes

(2019) Katarzyna Głombik et al.   NEUROTOXICITY RESEARCH

Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans

(2019) Mattea Müller et al.   Scientific Reports

Gut microbiota–brain axis in depression: The role of neuroinflammation

(2019) Anelise S. Carlessi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Glucagon-like peptide-1 suppresses neuroinflammation and improves neural structure

(2019) Gwangho Yoon et al.   PHARMACOLOGICAL RESEARCH

Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity

(2018) Han Weina et al.   BRAIN RESEARCH

Patients with anxious depression

(2018) Roxanne Gaspersz et al.   CURRENT OPINION IN PSYCHIATRY

Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus

(2018) Rui-Fang Wang et al.   EPILEPSY RESEARCH

Depression and obesity: evidence of shared biological mechanisms

(2018) Yuri Milaneschi et al.   MOLECULAR PSYCHIATRY

Cognitive dysfunction and metabolic comorbidities in mood disorders: A repurposing opportunity for glucagon-like peptide 1 receptor agonists?

(2018) Rodrigo B. Mansur et al.   NEUROPHARMACOLOGY

Repositioning of diabetes treatments for depressive symptoms: A systematic review and meta-analysis of clinical trials

(2018) Calum D. Moulton et al.   PSYCHONEUROENDOCRINOLOGY

Gut microbiome and depression: what we know and what we need to know

(2018) Gal Winter et al.   REVIEWS IN THE NEUROSCIENCES

The Effect of Low-Carbohydrate Diet on Glycemic Control in Patients with Type 2 Diabetes Mellitus

(2018) Li-Li Wang et al.   Nutrients

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

(2018) Josh Allen et al.   Frontiers in Neuroscience

Effects of glucagon-like peptide-1 receptor agonists on hypothalamic-pituitary-adrenal axis in healthy volunteers

(2018) Bettina Winzeler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Liraglutide modulates gut microbiota and reduces NAFLD in obese mice

(2018) GV Moreira et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Prevention of pentylenetetrazole-induced kindling and behavioral comorbidities in mice by levetiracetam combined with the GLP-1 agonist liraglutide: Involvement of brain antioxidant and BDNF upregulating properties

(2018) Alana Gomes de Souza et al.   BIOMEDICINE & PHARMACOTHERAPY

Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer’s and Parkinson’s Diseases

(2018) Andre F. Batista et al.   CNS DRUGS

Depression

(2018) Gin S Malhi et al.   LANCET

Hypothalamic insulin and glucagon-like peptide-1 levels in an animal model of depression and their effect on corticotropin-releasing hormone promoter gene activity in a hypothalamic cell line

(2018) Jan Detka et al.   Pharmacological Reports

Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring vervet monkeys

(2018) Morgane Thomsen et al.   PSYCHOPHARMACOLOGY

Possible role of GLP-1 in antidepressant effects of metformin and exercise in CUMS mice

(2018) Weina Liu et al.   JOURNAL OF AFFECTIVE DISORDERS

Treatment with a GLP−1R agonist over four weeks promotes weight loss-moderated changes in frontal-striatal brain structures in individuals with mood disorders

(2017) Rodrigo B. Mansur et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy

(2017) Paula Kopschina Feltes et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

(2017) Yan Zhang et al.   NATURE

Anxiety, Depression, and the Microbiome: A Role for Gut Peptides

(2017) Gilliard Lach et al.   Neurotherapeutics

Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity

(2017) Mario G. Oyola et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Exendin-4 Treatment Improves LPS-Induced Depressive-Like Behavior Without Affecting Pro-Inflammatory Cytokines

(2017) Filip Ventorp et al.   Journal of Parkinsons Disease

The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex

(2017) Wei Liu et al.   NEURAL PLASTICITY

A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation

(2017) Ryo Aoki et al.   Scientific Reports

GLP-1 and weight loss: unraveling the diverse neural circuitry

(2016) Scott E. Kanoski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF

(2016) Chenhui Ji et al.   BRAIN RESEARCH

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

(2016) Cristina García-Cáceres et al.   CELL

Mitochondrial Dysfunction in Depression

(2016) Yashika Bansal et al.   Current Neuropharmacology

Incretin therapies: highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors

(2016) M. Nauck   DIABETES OBESITY & METABOLISM

Omics Studies of the Murine Intestinal Ecosystem Exposed to Subchronic and Mild Social Defeat Stress

(2016) Ayako Aoki-Yoshida et al.   JOURNAL OF PROTEOME RESEARCH

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

(2016) John R. Kelly et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

(2016) P Zheng et al.   MOLECULAR PSYCHIATRY

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

GLP-1 is both anxiogenic and antidepressant; divergent effects of acute and chronic GLP-1 on emotionality

(2016) Rozita H Anderberg et al.   PSYCHONEUROENDOCRINOLOGY

Neural effects of gut- and brain-derived glucagon-like peptide-1 and its receptor agonist

(2016) Kenichi Katsurada et al.   Journal of Diabetes Investigation

Investigating incretin-based therapies as a novel treatment for depression in type 2 diabetes: Findings from the South London Diabetes (SOUL-D) Study

(2016) C.D. Moulton et al.   Primary Care Diabetes

Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis

(2016) Daiki Setoyama et al.   PLoS One

Glucocorticoids suppress GLP-1 secretion: possible contribution to their diabetogenic effects

(2015) Camilla Kappe et al.   CLINICAL SCIENCE

Intake ofLactobacillus reuteriImproves Incretin and Insulin Secretion in Glucose-Tolerant Humans: A Proof of Concept

(2015) Marie-Christine Simon et al.   DIABETES CARE

Depression in Type 2 Diabetes Mellitus: Prevalence, Impact, and Treatment

(2015) Katherine Semenkovich et al.   DRUGS

Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain

(2015) Kristy M. Heppner et al.   ENDOCRINOLOGY

Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes

(2015) M Christensen et al.   INTERNATIONAL JOURNAL OF OBESITY

Glucocorticoids decrease the production of glucagon-like peptide-1 at the transcriptional level in intestinal L-cells

(2015) Taiki Sato et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Brain glucose metabolism in an animal model of depression

(2015) J. Detka et al.   NEUROSCIENCE

Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors

(2015) Kelly J. Culhane et al.   Frontiers in Pharmacology

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

(2015) Simon C. Cork et al.   Molecular Metabolism

Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: Projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons

(2014) Kenichi Katsurada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbiota

(2014) Jeffrey D Galley et al.   BMC MICROBIOLOGY

GLP-1 and Exendin-4 Transiently Enhance GABAAReceptor–Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons

(2014) Sergiy V. Korol et al.   DIABETES

Corticotropin-Releasing Hormone and the Sympathoadrenal System Are Major Mediators in the Effects of Peripherally Administered Exendin-4 on the Hypothalamic-Pituitary-Adrenal Axis of Male Rats

(2014) Manuel Gil-Lozano et al.   ENDOCRINOLOGY

GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

(2014) Charles Pyke et al.   ENDOCRINOLOGY

Gastrointestinal hormones and the dialogue between gut and brain

(2014) Graham J. Dockray   JOURNAL OF PHYSIOLOGY-LONDON

Early-life stress and HPA axis trigger recurrent adulthood depression

(2013) Mario F. Juruena   EPILEPSY & BEHAVIOR

Innovative Drugs to Treat Depression: Did Animal Models Fail to Be Predictive or Did Clinical Trials Fail to Detect Effects?

(2013) Catherine Belzung   NEUROPSYCHOPHARMACOLOGY

Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

(2012) Kerry Hunter et al.   BMC NEUROSCIENCE

Potential Role of Glucagon-Like Peptide-1 (GLP-1) in Neuroprotection

(2012) Christian Hölscher   CNS DRUGS

Mitochondrial Alterations and Neuropsychiatric Disorders

(2012) D. Marazziti et al.   CURRENT MEDICINAL CHEMISTRY

Antiapoptotic Actions of Exendin-4 against Hypoxia and Cytokines Are Augmented by CREB

(2012) Kalpana Velmurugan et al.   ENDOCRINOLOGY

Action of glucagon-like peptide 1 and glucose levels on corticotropin-releasing factor and vasopressin gene expression in rat hypothalamic 4B cells

(2012) Kazunori Kageyama et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

GLP-1(7-36)-amide and Exendin-4 Stimulate the HPA Axis in Rodents and Humans

(2010) Manuel Gil-Lozano et al.   ENDOCRINOLOGY

Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

(2010) V A Gault et al.   INTERNATIONAL JOURNAL OF OBESITY

Glucocorticoids, cytokines and brain abnormalities in depression

(2010) Patricia A. Zunszain et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide-1 in the rat

(2009) v. bucinskaite et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Glucocorticoid regulation of preproglucagon transcription and RNA stability during stress

(2009) R. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of antidepressant drugs on the HPA axis activity, glucocorticoid receptor level and FKBP51 concentration in prenatally stressed rats

(2009) Magdalena Szymańska et al.   PSYCHONEUROENDOCRINOLOGY

Potential Prebiotic Properties of Almond (Amygdalus communis L.) Seeds

(2008) G. Mandalari et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

(2008) Michael Maes et al.   METABOLIC BRAIN DISEASE

Binge-type eating attenuates corticosterone and hypophagic responses to restraint stress

(2008) Kimberly P. Kinzig et al.   PHYSIOLOGY & BEHAVIOR