Exendin-4 Treatment Improves LPS-Induced Depressive-Like Behavior Without Affecting Pro-Inflammatory Cytokines

The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action

(2016) Dilan Athauda et al.   DRUG DISCOVERY TODAY

A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson’s disease by reducing chronic inflammation in the brain

(2016) Lijun Cao et al.   NEUROREPORT

GLP-1 is both anxiogenic and antidepressant; divergent effects of acute and chronic GLP-1 on emotionality

(2016) Rozita H Anderberg et al.   PSYCHONEUROENDOCRINOLOGY

Motor and Cognitive Advantages Persist 12 Months After Exenatide Exposure in Parkinson’s Disease

(2015) Iciar Aviles-Olmos et al.   Journal of Parkinsons Disease

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

The ongoing pursuit of neuroprotective therapies in Parkinson disease

(2014) Dilan Athauda et al.   Nature Reviews Neurology

Exendin-4 Reduces Ischemic Brain Injury in Normal and Aged Type 2 Diabetic Mice and Promotes Microglial M2 Polarization

(2014) Vladimer Darsalia et al.   PLoS One

Cerebrospinal fluid inflammatory markers in Parkinson’s disease – Associations with depression, fatigue, and cognitive impairment

(2013) Daniel Lindqvist et al.   BRAIN BEHAVIOR AND IMMUNITY

Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrus

(2013) Kazuma Kobayashi et al.   BRAIN RESEARCH

Neonatal Systemic Exposure to Lipopolysaccharide Enhances Susceptibility of Nigrostriatal Dopaminergic Neurons to Rotenone Neurotoxicity in Later Life

(2013) Zhengwei Cai et al.   DEVELOPMENTAL NEUROSCIENCE

Exenatide and the treatment of patients with Parkinson’s disease

(2013) Iciar Aviles-Olmos et al.   JOURNAL OF CLINICAL INVESTIGATION

The neuroprotective effects of GLP-1: Possible treatments for cognitive deficits in individuals with mood disorders

(2012) Roger S. McIntyre et al.   BEHAVIOURAL BRAIN RESEARCH

Retracted: Exendin-4 reverts behavioural and neurochemical dysfunction in a pre-motor rodent model of Parkinson's disease with noradrenergic deficit

(2012) N Rampersaud et al.   BRITISH JOURNAL OF PHARMACOLOGY

Potential Role of Glucagon-Like Peptide-1 (GLP-1) in Neuroprotection

(2012) Christian Hölscher   CNS DRUGS

Exendin-4 inhibits iNOS expression at the protein level in LPS-stimulated Raw264.7 macrophage by the activation of cAMP/PKA pathway

(2012) Seo-Yoon Chang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Exendin-4 treatment enhances L-DOPA evoked release of striatal dopamine and decreases dyskinetic movements in the 6-hydoxydopamine lesioned rat

(2012) Amjad Abuirmeileh et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Exendin-4 Protected against Cognitive Dysfunction in Hyperglycemic Mice Receiving an Intrahippocampal Lipopolysaccharide Injection

(2012) Hei-Jen Huang et al.   PLoS One

Changes in behaviour and cytokine expression upon a peripheral immune challenge

(2011) Cecilie Bay-Richter et al.   BEHAVIOURAL BRAIN RESEARCH

Anti-Inflammatory Properties of Exenatide in Human Pancreatic Islets

(2011) S. R. Cechin et al.   CELL TRANSPLANTATION

Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats

(2011) Vladimer Darsalia et al.   CLINICAL SCIENCE

The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test

(2010) Ruben Isacson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Val8-glucagon-like peptide-1 protects against Aβ1–40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats

(2010) X.H. Wang et al.   NEUROSCIENCE

Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamine

(2010) Ronise M. Santiago et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease

(2009) Talib Abbas et al.   BEHAVIOURAL BRAIN RESEARCH

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease

(2009) Sehee Kim et al.   JOURNAL OF ENDOCRINOLOGY

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

(2009) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid

(2008) Victor A. Gault et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease

(2008) Alexander Harkavyi et al.   Journal of Neuroinflammation

Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease

(2008) M.T. Tadaiesky et al.   NEUROSCIENCE

Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: Relationship with ventral striatum dopamine concentrations

(2008) Robert K. McNamara et al.   SYNAPSE

Reference genes for normalization: A study of rat brain tissue

(2008) Birgit Egeskov Bonefeld et al.   SYNAPSE

Incentive motivation is associated with striatal dopamine asymmetry

(2007) Rachel Tomer et al.   BIOLOGICAL PSYCHOLOGY

Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of parkinson's disease

(2007) Göran Bertilsson et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Glial reactions in Parkinson's disease

(2007) Patrick L. McGeer et al.   MOVEMENT DISORDERS

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH