The postnatal GABA shift: A developmental perspective

Cation–chloride cotransporters and the polarity of GABA signalling in mouse hippocampal parvalbumin interneurons

(2020) Yo Otsu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activity-Dependent Plasticity of Axo-axonic Synapses at the Axon Initial Segment

(2020) Alejandro Pan-Vazquez et al.   NEURON

Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit

(2020) Christopher K. Salmon et al.   Frontiers in Cellular Neuroscience

Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits

(2020) Alexandros K. Kanellopoulos et al.   CELL

Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex: an open-label pilot study

(2020) Dorinde M. van Andel et al.   Molecular Autism

The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles

(2020) Marco Capogna et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders

(2020) Annalisa Savardi et al.   Chem

GABAergic interneurons excite neonatal hippocampus in vivo

(2020) Yasunobu Murata et al.   Science Advances

Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes

(2020) Joshua L. Smalley et al.   Frontiers in Molecular Neuroscience

KCC2-Mediated Cl− Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice

(2019) Inkeri Spoljaric et al.   Cell Reports

Off-Label Use of Bumetanide for Brain Disorders: An Overview

(2019) Shivani C. Kharod et al.   Frontiers in Neuroscience

Chronic Subconvulsive Activity during Early Postnatal Life Produces Autistic Behavior in the Absence of Neurotoxicity in the Juvenile Weanling Period

(2019) LK Friedman et al.   BEHAVIOURAL BRAIN RESEARCH

Early alterations in a mouse model of Rett syndrome: the GABA developmental shift is abolished at birth

(2019) N. Lozovaya et al.   Scientific Reports

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function

(2019) Yvonne E. Moore et al.   Frontiers in Molecular Neuroscience

Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice

(2018) Qionger He et al.   MOLECULAR PSYCHIATRY

Chloride transporters and GABA polarity in developmental, neurological and psychiatric conditions

(2018) Joran T. Schulte et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Bumetanide for autism: more eye contact, less amygdala activation

(2018) Nouchine Hadjikhani et al.   Scientific Reports

KCC2 Regulates Dendritic Spine Formation in a Brain-Region Specific and BDNF Dependent Manner

(2018) Patricia Nora Awad et al.   CEREBRAL CORTEX

Maturation of GABAergic Transmission in Cerebellar Purkinje Cells Is Sex Dependent and Altered in the Valproate Model of Autism

(2018) Sébastien Roux et al.   Frontiers in Cellular Neuroscience

The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice

(2018) Camille Dumon et al.   eLife

A novel GABAergic dysfunction in human Dravet syndrome

(2018) Gabriele Ruffolo et al.   EPILEPSIA

Ionotropic and metabotropic kainate receptor signalling regulates Cl− homeostasis and GABAergic inhibition

(2018) Danielle Garand et al.   JOURNAL OF PHYSIOLOGY-LONDON

Giant Depolarizing Potentials Trigger Transient Changes in the Intracellular Cl- Concentration in CA3 Pyramidal Neurons of the Immature Mouse Hippocampus

(2018) Aniello Lombardi et al.   Frontiers in Cellular Neuroscience

Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA B Receptor Protein Complex

(2017) Rebecca Wright et al.   JOURNAL OF NEUROSCIENCE

Early IGF-1 primes visual cortex maturation and accelerates developmental switch between NKCC1 and KCC2 chloride transporters in enriched animals

(2017) Laura Baroncelli et al.   NEUROPHARMACOLOGY

Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo

(2017) Sebastian Sulis Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics

(2017) Hayder Amin et al.   Scientific Reports

Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment

(2017) Gina Rinetti-Vargas et al.   Cell Reports

Effects of bumetanide on neurobehavioral function in children and adolescents with autism spectrum disorders

(2017) E Lemonnier et al.   Translational Psychiatry

Intracellular chloride ion concentration in differentiating neuronal cell and its role in growing neurite

(2016) Ken-ichi Nakajima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pro-Brain-Derived Neurotrophic Factor (proBDNF)-Mediated p75NTR Activation Promotes Depolarizing Actions of GABA and Increases Susceptibility to Epileptic Seizures

(2016) Baptiste Riffault et al.   CEREBRAL CORTEX

The membrane trafficking and functionality of the K+-Cl−co-transporter KCC2 is regulated by TGF-β2

(2016) Eleni Roussa et al.   JOURNAL OF CELL SCIENCE

An Optogenetic Approach for Investigation of Excitatory and Inhibitory Network GABA Actions in Mice Expressing Channelrhodopsin-2 in GABAergic Neurons

(2016) Guzel Valeeva et al.   JOURNAL OF NEUROSCIENCE

Functional aspects of early brain development are preserved in tuberous sclerosis complex (TSC) epileptogenic lesions

(2016) Gabriele Ruffolo et al.   NEUROBIOLOGY OF DISEASE

KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome

(2016) Xin Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome

(2016) Abhishek Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo synaptogenesis induced by GABA in the developing mouse cortex

(2016) Won Chan Oh et al.   SCIENCE

The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2

(2016) Marianna Leonzino et al.   Cell Reports

Epilepsy and Autism

(2016) Ashura W. Buckley et al.   Cold Spring Harbor Perspectives in Medicine

Spindle Bursts in Neonatal Rat Cerebral Cortex

(2016) Jenq-Wei Yang et al.   NEURAL PLASTICITY

Dynamic Changes from Depolarizing to Hyperpolarizing GABAergic Actions during Giant Depolarizing Potentials in the Neonatal Rat Hippocampus

(2015) I. Khalilov et al.   JOURNAL OF NEUROSCIENCE

KCC2 Gates Activity-Driven AMPA Receptor Traffic through Cofilin Phosphorylation

(2015) Q. Chevy et al.   JOURNAL OF NEUROSCIENCE

Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome

(2015) Gabriele Deidda et al.   NATURE MEDICINE

Treatment during a vulnerable developmental period rescues a genetic epilepsy

(2015) Stephan Lawrence Marguet et al.   NATURE MEDICINE

Sensory-Evoked Spiking Behavior Emerges via an Experience-Dependent Plasticity Mechanism

(2015) Joram J. van Rheede et al.   NEURON

BDNF is required for seizure-induced but not developmental up-regulation of KCC2 in the neonatal hippocampus

(2015) Martin Puskarjov et al.   NEUROPHARMACOLOGY

Paradoxical Benzodiazepine Response: A Rationale for Bumetanide in Neurodevelopmental Disorders?

(2015) H. Bruining et al.   PEDIATRICS

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons

(2015) Perrine Friedel et al.   Science Signaling

Control of cortical neuronal migration by glutamate and GABA

(2015) Heiko J. Luhmann et al.   Frontiers in Cellular Neuroscience

Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia

(2015) Nancy D. Merner et al.   Frontiers in Cellular Neuroscience

Age- and sex-dependent susceptibility to phenobarbital-resistant neonatal seizures: role of chloride co-transporters

(2015) Seok Kyu Kang et al.   Frontiers in Cellular Neuroscience

GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo

(2015) Knut Kirmse et al.   Nature Communications

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons

(2015) Perrine Friedel et al.   Science Signaling

Postnatal Erythropoietin Mitigates Impaired Cerebral Cortical Development Following Subplate Loss from Prenatal Hypoxia–Ischemia

(2014) Lauren L. Jantzie et al.   CEREBRAL CORTEX

The Developmental Switch in GABA Polarity Is Delayed in Fragile X Mice

(2014) Q. He et al.   JOURNAL OF NEUROSCIENCE

Neonatal allopregnanolone or finasteride administration modifies hippocampal K+ Cl− co-transporter expression during early development in male rats

(2014) Laura Mòdol et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Early depolarizing GABA controls critical-period plasticity in the rat visual cortex

(2014) Gabriele Deidda et al.   NATURE NEUROSCIENCE

K-Cl cotransporter KCC2—a moonlighting protein in excitatory and inhibitory synapse development and function

(2014) Peter Blaesse et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

(2014) R. Tyzio et al.   SCIENCE

Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2

(2014) Igor Medina et al.   Frontiers in Cellular Neuroscience

Association of gestational maternal hypothyroxinemia and increased autism risk

(2013) Gustavo C. Román et al.   ANNALS OF NEUROLOGY

Regional differences in the expression of K+–Cl− 2 cotransporter in the developing rat cortex

(2013) Krisztina Kovács et al.   Brain Structure & Function

Thyroid hormone-dependent development of the GABAergic pre- and post-synaptic components in the rat hippocampus

(2013) Erika Sawano et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

GABA Depolarization Is Required for Experience-Dependent Synapse Unsilencing in Adult-Born Neurons

(2013) J. H. Chancey et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Regulation of the K/Cl Transporter KCC2 Membrane Diffusion, Clustering, and Function in Hippocampal Neurons

(2013) I. Chamma et al.   JOURNAL OF NEUROSCIENCE

The developmental stages of synaptic plasticity

(2013) Christian Lohmann et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Theory of the Transition to Critical Period Plasticity: Inhibition Selectively Suppresses Spontaneous Activity

(2013) Taro Toyoizumi et al.   NEURON

GABAergic Interneurons Shape the Functional Maturation of the Cortex

(2013) Corentin Le Magueresse et al.   NEURON

NKCC1 and KCC2 protein expression is sexually dimorphic in the hippocampus and entorhinal cortex of neonatal rats

(2013) Justo Murguía-Castillo et al.   NEUROSCIENCE LETTERS

Abnormal Expression of Cerebrospinal Fluid Cation Chloride Cotransporters in Patients with Rett Syndrome

(2013) Sofia Temudo Duarte et al.   PLoS One

Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2

(2013) Kristopher T. Kahle et al.   TRENDS IN NEUROSCIENCES

An unexpected role of neuroligin-2 in regulating KCC2 and GABA functional switch

(2013) Chicheng Sun et al.   Molecular Brain

An Ion Transport-Independent Role for the Cation-Chloride Cotransporter KCC2 in Dendritic Spinogenesis In Vivo

(2012) H. Fiumelli et al.   CEREBRAL CORTEX

Taurine Inhibits K+-Cl−Cotransporter KCC2 to Regulate Embryonic Cl−Homeostasis via With-no-lysine (WNK) Protein Kinase Signaling Pathway

(2012) Koichi Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NKCC1 Knockdown Decreases Neuron Production through GABAA-Regulated Neural Progenitor Proliferation and Delays Dendrite Development

(2012) S. Z. Young et al.   JOURNAL OF NEUROSCIENCE

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

(2012) Juan Song et al.   NATURE

Effects of sex and chronic neonatal nicotine treatment on Na2+/K+/Cl− co-transporter 1, K+/Cl− co-transporter 2, brain-derived neurotrophic factor, NMDA receptor subunit 2A and NMDA receptor subunit 2B mRNA expression in the postnatal rat hippocampus

(2012) J.C. Damborsky et al.   NEUROSCIENCE

Intracellular chloride concentration influences the GABAA receptor subunit composition

(2012) Francesca Succol et al.   Nature Communications

A randomised controlled trial of bumetanide in the treatment of autism in children

(2012) E Lemonnier et al.   Translational Psychiatry

Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia

(2011) Delia M. Talos et al.   ANNALS OF NEUROLOGY

Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10

(2011) Peng Cao et al.   CELL

Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis

(2011) Venceslas Duveau et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons

(2011) Ying Huang et al.   EXPERIMENTAL NEUROLOGY

The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies

(2011) Meera E. Modi et al.   HORMONES AND BEHAVIOR

Positive Feedback Regulation between γ-Aminobutyric Acid Type A (GABAA) Receptor Signaling and Brain-derived Neurotrophic Factor (BDNF) Release in Developing Neurons

(2011) Christophe Porcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Shh/miR-206/BDNF Cascade Coordinates Innervation and Formation of Airway Smooth Muscle

(2011) K. Radzikinas et al.   JOURNAL OF NEUROSCIENCE

Early Growth Response 4 Mediates BDNF Induction of Potassium Chloride Cotransporter 2 Transcription

(2011) A. Ludwig et al.   JOURNAL OF NEUROSCIENCE

GABA Regulates the Multidirectional Tangential Migration of GABAergic Interneurons in Living Neonatal Mice

(2011) Hiroyuki Inada et al.   PLoS One

Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells

(2011) R. N. Fernando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines

(2011) G. Gauvain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Gamma Oscillations Synchronize Developing Thalamus and Cortex

(2011) M. Minlebaev et al.   SCIENCE

The diuretic bumetanide decreases autistic behaviour in five infants treated during 3 months with no side effects

(2010) Eric Lemonnier et al.   ACTA PAEDIATRICA

Blocking Early GABA Depolarization with Bumetanide Results in Permanent Alterations in Cortical Circuits and Sensorimotor Gating Deficits

(2010) Doris D. Wang et al.   CEREBRAL CORTEX

An Update on GABAρ Receptors

(2010) Gustavo Martinez-Delgado et al.   Current Neuropharmacology

Developmental Time Course of Estradiol, Testosterone, and Dihydrotestosterone Levels in Discrete Regions of Male and Female Rat Brain

(2010) Anne T. M. Konkle et al.   ENDOCRINOLOGY

Differential distribution of KCC2 along the axo-somato-dendritic axis of hippocampal principal cells

(2010) Rita Báldi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Possible involvement of DNA methylation in NKCC1 gene expression during postnatal development and in response to ischemia

(2010) Hae-Ahm Lee et al.   JOURNAL OF NEUROCHEMISTRY

Early Enriched Environment Promotes Neonatal GABAergic Neurotransmission and Accelerates Synapse Maturation

(2010) S. He et al.   JOURNAL OF NEUROSCIENCE

Recruitment of Early Postnatal Parvalbumin-Positive Hippocampal Interneurons by GABAergic Excitation

(2010) J.-F. Sauer et al.   JOURNAL OF NEUROSCIENCE

GABA Depolarizes Immature Neocortical Neurons in the Presence of the Ketone Body  -Hydroxybutyrate

(2010) K. Kirmse et al.   JOURNAL OF NEUROSCIENCE

GABAC receptors are functionally expressed in the intermediate zone and regulate radial migration in the embryonic mouse neocortex

(2010) D.G. Denter et al.   NEUROSCIENCE

GABAA Receptor Signaling Induces Osmotic Swelling and Cell Cycle Activation of Neonatal Prominin+ Precursors

(2010) Tiziana Cesetti et al.   STEM CELLS

GABAergic control of neurite outgrowth and remodeling during development and adult neurogenesis: general rules and differences in diverse systems

(2010) Evelyne Sernagor   Frontiers in Cellular Neuroscience

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

(2009) Jesse Rinehart et al.   CELL

NKCC1-Dependent GABAergic Excitation Drives Synaptic Network Maturation during Early Hippocampal Development

(2009) C. K. Pfeffer et al.   JOURNAL OF NEUROSCIENCE

Setting the Pace for Retinal Development: Environmental Enrichment Acts Through Insulin-Like Growth Factor 1 and Brain-Derived Neurotrophic Factor

(2009) S. Landi et al.   JOURNAL OF NEUROSCIENCE

Control of Cortical Axon Elongation by a GABA-Driven Ca2+/Calmodulin-Dependent Protein Kinase Cascade

(2009) N. Ageta-Ishihara et al.   JOURNAL OF NEUROSCIENCE

Defining the role of GABA in cortical development

(2009) Doris D. Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Thyroxin regulates BDNF expression to promote survival of injured neurons

(2009) Anastasia Shulga et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuronal release of proBDNF

(2009) Jianmin Yang et al.   NATURE NEUROSCIENCE

Mechanisms underlying spontaneous patterned activity in developing neural circuits

(2009) Aaron G. Blankenship et al.   NATURE REVIEWS NEUROSCIENCE

KCC2 Expression Promotes the Termination of Cortical Interneuron Migration in a Voltage-Sensitive Calcium-Dependent Manner

(2009) Dante Bortone et al.   NEURON

Hypothyroidism impairs chloride homeostasis and onset of inhibitory neurotransmission in developing auditory brainstem and hippocampal neurons

(2008) Eckhard Friauf et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

GABA Actions in Hippocampal Area CA3 During Postnatal Development: Differential Shift From Depolarizing to Hyperpolarizing in Somatic and Dendritic Compartments

(2008) Héctor Romo-Parra et al.   JOURNAL OF NEUROPHYSIOLOGY

Altered Synaptic Dynamics and Hippocampal Excitability but Normal Long-Term Plasticity in Mice Lacking Hyperpolarizing GABAA Receptor-Mediated Inhibition in CA1 Pyramidal Neurons

(2008) Ruusu Riekki et al.   JOURNAL OF NEUROPHYSIOLOGY

Excitatory GABA in Rodent Developing Neocortex In Vitro

(2008) Sylvain Rheims et al.   JOURNAL OF NEUROPHYSIOLOGY

Neurogenic Role of the Depolarizing Chloride Gradient Revealed by Global Overexpression of KCC2 from the Onset of Development

(2008) A. Reynolds et al.   JOURNAL OF NEUROSCIENCE

GABA Regulates Excitatory Synapse Formation in the Neocortex via NMDA Receptor Activation

(2008) D. D. Wang et al.   JOURNAL OF NEUROSCIENCE

Sequential Generation of Two Distinct Synapse-Driven Network Patterns in Developing Neocortex

(2008) C. Allene et al.   JOURNAL OF NEUROSCIENCE

Dissociated Gender-Specific Effects of Recurrent Seizures on GABA Signaling in CA1 Pyramidal Neurons: Role of GABAA Receptors

(2008) A. S. Galanopoulou   JOURNAL OF NEUROSCIENCE

Histone H2AX-dependent GABAA receptor regulation of stem cell proliferation

(2008) Michael Andäng et al.   NATURE