Journal
CURRENT NEUROPHARMACOLOGY
Volume 8, Issue 4, Pages 422-433Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157015910793358141
Keywords
GABA receptor gene organization; Ligand Gated Ion Channel; Receptor structure; TPMPA
Categories
Funding
- CONACYT-MEXICO
- CONACYT [101851]
- PA-PIIT-UNAM
Ask authors/readers for more resources
The present review discusses the functional and molecular diversity of GABA rho receptors. These receptors were originally described in the mammalian retina, and their functional role in the visual pathway has been recently elucidated; however new studies on their distribution in the brain and spinal cord have revealed that they are more spread than originally thought, and thus it will be important to determine their physiological contribution to the GABAergic trans-mission in other areas of the central nervous system. In addition, molecular modeling has revealed peculiar traits of these receptors that have impacted on the interpretations of the latest pharmacolgical and biophysical findings. Finally, sequencing of several vertebrate genomes has permitted a comparative analysis of the organization of the GABA rho genes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available