K-Cl cotransporter KCC2—a moonlighting protein in excitatory and inhibitory synapse development and function

Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts

(2013) Kenneth B. Gagnon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Electrical Compartmentalization in Dendritic Spines

(2013) Rafael Yuste   Annual Review of Neuroscience

GABA actions and ionic plasticity in epilepsy

(2013) Kai Kaila et al.   CURRENT OPINION IN NEUROBIOLOGY

Disrupted Cl−homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states

(2013) Tarek Z. Deeb et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Targeting calpain in synaptic plasticity

(2013) Michel Baudry et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Genomics of alternative splicing: evolution, development and pathophysiology

(2013) Eric R. Gamazon et al.   HUMAN GENETICS

Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS

(2013) Marika Markkanen et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Activity-Dependent Regulation of the K/Cl Transporter KCC2 Membrane Diffusion, Clustering, and Function in Hippocampal Neurons

(2013) I. Chamma et al.   JOURNAL OF NEUROSCIENCE

Evolution of the Cation Chloride Cotransporter Family: Ancient Origins, Gene Losses, and Subfunctionalization through Duplication

(2013) Anna-Maria Hartmann et al.   MOLECULAR BIOLOGY AND EVOLUTION

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

Protein adaptation: mitotic functions for membrane trafficking proteins

(2013) Stephen J. Royle   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2

(2013) Kristopher T. Kahle et al.   TRENDS IN NEUROSCIENCES

Moonlighting is mainstream: Paradigm adjustment required

(2012) Shelley D. Copley   BIOESSAYS

An Ion Transport-Independent Role for the Cation-Chloride Cotransporter KCC2 in Dendritic Spinogenesis In Vivo

(2012) H. Fiumelli et al.   CEREBRAL CORTEX

Raising cytosolic Cl−in cerebellar granule cells affects their excitability and vestibulo-ocular learning

(2012) Patricia Seja et al.   EMBO JOURNAL

N-Methyl-d-aspartate Receptor- and Calpain-mediated Proteolytic Cleavage of K+-Cl−Cotransporter-2 Impairs Spinal Chloride Homeostasis in Neuropathic Pain

(2012) Hong-Yi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Dependent Cleavage of the K-Cl Cotransporter KCC2 Mediated by Calcium-Activated Protease Calpain

(2012) M. Puskarjov et al.   JOURNAL OF NEUROSCIENCE

RVG-Mediated Calpain2 Gene Silencing in the Brain Impairs Learning and Memory

(2012) Sohila Zadran et al.   NEUROMOLECULAR MEDICINE

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

(2012) Wolfgang Löscher et al.   NEUROPHARMACOLOGY

SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro

(2012) R.A. Saadi et al.   NEUROSCIENCE

The GABA Excitatory/Inhibitory Shift in Brain Maturation and Neurological Disorders

(2012) Yehezkel Ben-Ari et al.   NEUROSCIENTIST

Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2

(2012) R. Bos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission

(2012) Ingrid Chamma et al.   Frontiers in Cellular Neuroscience

Two types of chloride transporters are required for GABAAreceptor-mediated inhibition inC. elegans

(2011) Andrew Bellemer et al.   EMBO JOURNAL

Upregulation of KCC2 Activity by Zinc-Mediated Neurotransmission via the mZnR/GPR39 Receptor

(2011) E. Chorin et al.   JOURNAL OF NEUROSCIENCE

The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism

(2011) Wei-Chun Wei et al.   JOURNAL OF PHYSIOLOGY-LONDON

Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival

(2011) Christophe Pellegrino et al.   JOURNAL OF PHYSIOLOGY-LONDON

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents

(2011) Henry H C Lee et al.   NATURE NEUROSCIENCE

The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines

(2011) G. Gauvain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism

(2010) Zachi Horn et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Brain-Derived Neurotrophic Factor and Epidermal Growth Factor Activate Neuronal m-Calpain via Mitogen-Activated Protein Kinase-Dependent Phosphorylation

(2010) S. Zadran et al.   JOURNAL OF NEUROSCIENCE

A Single Seizure Episode Leads to Rapid Functional Activation of KCC2 in the Neonatal Rat Hippocampus

(2010) S. Khirug et al.   JOURNAL OF NEUROSCIENCE

Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury

(2010) Pascale Boulenguez et al.   NATURE MEDICINE

Regulation of GABAergic synapse formation and plasticity by GSK3 -dependent phosphorylation of gephyrin

(2010) S. K. Tyagarajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloride regulation in the pain pathway

(2009) Theodore J. Price et al.   BRAIN RESEARCH REVIEWS

Coexpression and Heteromerization of Two Neuronal K-Cl Cotransporter Isoforms in Neonatal Brain

(2009) Pavel Uvarov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clustering of Neuronal K+-Cl−Cotransporters in Lipid Rafts by Tyrosine Phosphorylation

(2009) Miho Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Potassium Chloride Cotransporter KCC-2 Coordinates Development of Inhibitory Neurotransmission and Synapse Structure in Caenorhabditis elegans

(2009) J. E. Tanis et al.   JOURNAL OF NEUROSCIENCE

Moonlighting proteins—an update

(2009) Constance J. Jeffery   Molecular BioSystems

Intracellular zinc inhibits KCC2 transporter activity

(2009) Michal Hershfinkel et al.   NATURE NEUROSCIENCE

Cation-Chloride Cotransporters and Neuronal Function

(2009) Peter Blaesse et al.   NEURON

Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2

(2009) E. Delpire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

17- -Estradiol increases neuronal excitability through MAP kinase-induced calpain activation

(2009) S. Zadran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycinergic tonic inhibition of hippocampal neurons with depolarizing GABAergic transmission elicits histopathological signs of temporal lobe epilepsy

(2008) Sabrina A. Eichler et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tonic activation of group I mGluRs modulates inhibitory synaptic strength by regulating KCC2 activity

(2008) Tue G. Banke et al.   JOURNAL OF PHYSIOLOGY-LONDON

Roles of the cation–chloride cotransporters in neurological disease

(2008) Kristopher T Kahle et al.   Nature clinical practice. Neurology