A novel GABAergic dysfunction in human Dravet syndrome

Treatment Strategies for Dravet Syndrome

(2018) Kelly G. Knupp et al.   CNS DRUGS

Modulation of GABAA Receptors in the Treatment of Epilepsy

(2018) Eleonora Palma et al.   CURRENT PHARMACEUTICAL DESIGN

KCC2, epileptiform synchronization, and epileptic disorders

(2018) Graziella Di Cristo et al.   PROGRESS IN NEUROBIOLOGY

Overexpressing wild-type γ2 subunits rescued the seizure phenotype in Gabrg2 +/Q390X Dravet syndrome mice

(2017) Xuan Huang et al.   EPILEPSIA

Dravet syndrome and its mimics: Beyond SCN1A

(2017) Dora Steel et al.   EPILEPSIA

Impaired intracortical inhibition demonstrated in vivo in people with Dravet syndrome

(2017) William M. Stern et al.   NEUROLOGY

Mutations in GABRB3

(2017) Rikke S. Møller et al.   NEUROLOGY

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

(2017) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABA A receptors

(2017) T. Bakas et al.   PHARMACOLOGICAL RESEARCH

Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome

(2017) Joshua S. Kaplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex

(2016) Evan J. Hess et al.   EPILEPSIA

Functional aspects of early brain development are preserved in tuberous sclerosis complex (TSC) epileptogenic lesions

(2016) Gabriele Ruffolo et al.   NEUROBIOLOGY OF DISEASE

Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome

(2016) Abhishek Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients

(2016) Yishan Sun et al.   eLife

Neurological and neuropsychiatric aspects of tuberous sclerosis complex

(2015) Paolo Curatolo et al.   LANCET NEUROLOGY

Tonic GABAA Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy

(2015) S. Schipper et al.   MOLECULAR NEUROBIOLOGY

Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome

(2015) Gabriele Deidda et al.   NATURE MEDICINE

The GABAA Receptor as a Therapeutic Target for Neurodevelopmental Disorders

(2015) Sien Braat et al.   NEURON

Incidence of Dravet Syndrome in a US Population

(2015) Y. W. Wu et al.   PEDIATRICS

Basic Mechanisms of Epileptogenesis in Pediatric Cortical Dysplasia

(2014) Sara Abdijadid et al.   CNS Neuroscience & Therapeutics

Effect of spontaneous seizures on GABAAreceptor α4 subunit expression in an animal model of temporal lobe epilepsy

(2014) Heidi L Grabenstatter et al.   EPILEPSIA

Cation-chloride cotransporters in neuronal development, plasticity and disease

(2014) Kai Kaila et al.   NATURE REVIEWS NEUROSCIENCE

Untangling the Dravet Syndrome Seizure Network: The Changing Face of a Rare Genetic Epilepsy

(2014) Ravi Chopra et al.   Epilepsy Currents

Stiripentol exhibits higher anticonvulsant properties in the immature than in the mature rat brain

(2013) Stéphane Auvin et al.   EPILEPSIA

Fractalkine/CX3CL1 modulates GABAAcurrents in human temporal lobe epilepsy

(2013) Cristina Roseti et al.   EPILEPSIA

A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABAAreceptors

(2012) ML Jensen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia

(2011) Delia M. Talos et al.   ANNALS OF NEUROLOGY

Anomalous levels of Cl− transporters cause a decrease of GABAergic inhibition in human peritumoral epileptic cortex

(2011) Luca Conti et al.   EPILEPSIA

KCC2 was downregulated in small neurons localized in epileptogenic human focal cortical dysplasia

(2011) Chigusa Shimizu-Okabe et al.   EPILEPSY RESEARCH

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

Comparative study of cellular and synaptic abnormalities in brain tissue samples from pediatric tuberous sclerosis complex and cortical dysplasia type II

(2010) Carlos Cepeda et al.   EPILEPSIA

Progressive NKCC1-Dependent Neuronal Chloride Accumulation during Neonatal Seizures

(2010) V. I. Dzhala et al.   JOURNAL OF NEUROSCIENCE

Epileptogenesis in the immature brain: emerging mechanisms

(2009) Sanjay N. Rakhade et al.   Nature Reviews Neurology

Microtransplantation of ligand-gated receptor-channels from fresh or frozen nervous tissue into Xenopus oocytes: A potent tool for expanding functional information

(2009) F. Eusebi et al.   PROGRESS IN NEUROBIOLOGY

GABAA Receptors in Normal Development and Seizures: Friends or Foes?

(2008) Aristea Galanopoulou   Current Neuropharmacology