IL-6 Regulates Hepcidin Expression Via the BMP/SMAD Pathway by Altering BMP6, TMPRSS6 and TfR2 Expressions at Normal and Inflammatory Conditions in BV2 Microglia

Iron metabolism and iron disorders revisited in the hepcidin era

(2020) Clara Camaschella et al.   HAEMATOLOGICA

Fractalkine Induces Hepcidin Expression of BV-2 Microglia and Causes Iron Accumulation in SH-SY5Y Cells

(2019) Edina Pandur et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Inflammation-induced iron transport and metabolism by brain microglia

(2018) Ryan C. McCarthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in Hepcidin and Hemoglobin After Anti-TNF-alpha Therapy in Children and Adolescents With Crohn Disease

(2018) Meredith A. Atkinson et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

An Overview of in vitro Methods to Study Microglia

(2018) Raissa Timmerman et al.   Frontiers in Cellular Neuroscience

Liver iron sensing and body iron homeostasis

(2018) Chia-Yu Wang et al.   BLOOD

NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression

(2018) Tabea Riedlinger et al.   FASEB JOURNAL

Effect of Inflammatory Mediators Lipopolysaccharide and Lipoteichoic Acid on Iron Metabolism of Differentiated SH-SY5Y Cells Alters in the Presence of BV-2 Microglia

(2018) Edina Pandur et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis

(2017) Lin-Hao You et al.   Cell Death & Disease

Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics

(2017) Wei Gao et al.   Frontiers in Physiology

STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence

(2016) Benjamin L. Bryson et al.   CELL CYCLE

Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice

(2016) Susanna Canali et al.   ENDOCRINOLOGY

Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes

(2016) Simeng Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Regulation of NF-κB Subunits by Phosphorylation

(2016) Frank Christian et al.   Cells

Hepcidin: regulation of the master iron regulator

(2015) Gautam Rishi et al.   BIOSCIENCE REPORTS

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

STAT3 selectively interacts with Smad3 to antagonize TGF-β

(2015) G Wang et al.   ONCOGENE

JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells

(2014) RENG-YUN LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration

(2014) Karen Rosenberger et al.   Journal of Neuroinflammation

The extrahepatic role of TFR2 in iron homeostasis

(2014) Laura Silvestri et al.   Frontiers in Pharmacology

The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body

(2014) Christal A. Worthen et al.   Frontiers in Pharmacology

Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis

(2014) Amanda B. Core et al.   Frontiers in Pharmacology

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Prohepcidin binds to theHAMPpromoter and autoregulates its own expression

(2013) Edina Pandur et al.   BIOCHEMICAL JOURNAL

Iron in Infection and Immunity

(2013) James E. Cassat et al.   Cell Host & Microbe

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

(2013) Pamela Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Activation of the NF-κB Pathway by the STAT3 Inhibitor JSI-124 in Human Glioblastoma Cells

(2013) Braden C. McFarland et al.   MOLECULAR CANCER RESEARCH

Inflammation Regulates TMPRSS6 Expression via STAT5

(2013) Delphine Meynard et al.   PLoS One

Involvement of PKA and HO-1 signaling in anti-inflammatory effects of surfactin in BV-2 microglial cells

(2013) Sun Young Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Microglia and Synapse: Interactions in Health and Neurodegeneration

(2013) Zuzana Šišková et al.   NEURAL PLASTICITY

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

(2012) C. Besson-Fournier et al.   BLOOD

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

(2012) Flavia D’Alessio et al.   JOURNAL OF HEPATOLOGY

LPS-induced release of IL-6 from glia modulates production of IL-1β in a JAK2-dependent manner

(2012) Aedín M Minogue et al.   Journal of Neuroinflammation

Hepcidin Regulation by BMP Signaling in Macrophages Is Lipopolysaccharide Dependent

(2012) Xinggang Wu et al.   PLoS One

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

(2011) D. Meynard et al.   BLOOD

The Yin and Yang of Microglia

(2011) Melinda Czeh et al.   DEVELOPMENTAL NEUROSCIENCE

The hepcidin circuits act: Balancing iron and inflammation

(2011) Bryan D. Maliken et al.   HEPATOLOGY

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Nuclear factor-κB mediated lipopolysaccharide-induced mRNA expression of hepcidin in human peripheral blood leukocytes

(2011) ShuiJing Wu et al.   Innate Immunity

Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation

(2010) M. Poli et al.   HAEMATOLOGICA

Induction of Interleukin-6 Expression by Bone Morphogenetic Protein-6 in Macrophages Requires Both SMAD and p38 Signaling Pathways

(2010) Geun Taek Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR-signaling Networks

(2010) J. Brown et al.   JOURNAL OF DENTAL RESEARCH

The Role of Hepcidin in Iron Metabolism

(2009) Elizabeta Nemeth et al.   ACTA HAEMATOLOGICA

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

(2009) Junwei Gao et al.   Cell Metabolism

α-1 Antitrypsin binds preprohepcidin intracellularly and prohepcidin in the serum

(2009) Edina Pandur et al.   FEBS Journal

Role of STAT1, NF-κB, and C/EBPβ in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN-γ

(2009) Fatoumata B. Sow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Bacterial ligand of TLR2 signals Stat activation via induction of IRF1/2 and interferon-α production

(2008) Mari Liljeroos et al.   CELLULAR SIGNALLING

Hypoxia-Independent Activation of HIF-1 by Enterobacteriaceae and Their Siderophores

(2008) Hanna Hartmann et al.   GASTROENTEROLOGY

A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells

(2008) Maria Vittoria Verga Falzacappa et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin

(2007) Erika V. Valore et al.   BLOOD CELLS MOLECULES AND DISEASES

Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS

(2003) Nathalie Laflamme et al.   JOURNAL OF NEUROCHEMISTRY