The roles of Polycomb repressive complexes in mammalian development and cancer

A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin

(2020) Siming Chen et al.   MOLECULAR CELL

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

(2020) Kulandaimanuvel Antony Michealraj et al.   CELL

Diffuse intrinsic pontine glioma-like tumor with EZHIP expression and molecular features of PFA ependymoma

(2020) Drew Pratt et al.   Acta Neuropathologica Communications

Epigenetic regulator function through mouse gastrulation

(2020) Stefanie Grosswendt et al.   NATURE

H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2

(2020) Siddhant U. Jain et al.   MOLECULAR CELL

COMPASS and SWI/SNF complexes in development and disease

(2020) Bercin K. Cenik et al.   NATURE REVIEWS GENETICS

Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors

(2020) Jichang Han et al.   CANCER CELL

EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer

(2019) Michel Wassef et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma

(2019) Jens-Martin Hübner et al.   NEURO-ONCOLOGY

RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2

(2019) Qi Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities

(2019) Andrea Scelfo et al.   MOLECULAR CELL

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

(2019) Nadezda A. Fursova et al.   MOLECULAR CELL

Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation

(2019) Anne Laugesen et al.   MOLECULAR CELL

Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2

(2019) Aaron J. Plys et al.   GENES & DEVELOPMENT

Histone H3K27 dimethyl loss is highly specific for malignant peripheral nerve sheath tumor and distinguishes true PRC2 loss from isolated H3K27 trimethyl loss

(2019) Dylan M. Marchione et al.   MODERN PATHOLOGY

CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

(2019) Andrea Piunti et al.   Science Advances

CBX3/HP1γ promotes tumor proliferation and predicts poor survival in hepatocellular carcinoma

(2019) Xiaoping Zhong et al.   Aging-US

PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation

(2019) Zhihong Ren et al.   BLOOD

PRC2 functions in development and congenital disorders

(2019) Orla Deevy et al.   DEVELOPMENT

Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity

(2019) Jonas Westergaard Højfeldt et al.   MOLECULAR CELL

PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation

(2019) Evan Healy et al.   MOLECULAR CELL

The Complexity of PRC2 Subcomplexes

(2019) Guido van Mierlo et al.   TRENDS IN CELL BIOLOGY

CBX3 promotes glioma U87 cell proliferation and predicts an unfavorable prognosis

(2019) Shu-Peng Zhao et al.   JOURNAL OF NEURO-ONCOLOGY

HNF1B-mediated repression of SLUG is suppressed by EZH2 in aggressive prostate cancer

(2019) Jianqing Wang et al.   ONCOGENE

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

(2019) Roberta Ragazzini et al.   Nature Communications

Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

(2019) Simone Tamburri et al.   MOLECULAR CELL

PRC1 Catalytic Activity Is Central to Polycomb System Function

(2019) Neil P. Blackledge et al.   MOLECULAR CELL

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

(2018) Kristian W. Pajtler et al.   ACTA NEUROPATHOLOGICA

Genetics of diffuse large B-cell lymphoma

(2018) Laura Pasqualucci et al.   BLOOD

Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2

(2018) Chul-Hwan Lee et al.   MOLECULAR CELL

A Family of Vertebrate-Specific Polycombs Encoded by the LCOR / LCORL Genes Balance PRC2 Subtype Activities

(2018) Eric Conway et al.   MOLECULAR CELL

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

(2018) Lu Wang et al.   NATURE MEDICINE

Structures of human PRC2 with its cofactors AEBP2 and JARID2

(2018) Vignesh Kasinath et al.   SCIENCE

Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis

(2018) Janet L. Manias Rothberg et al.   Cell Discovery

Targeting the MTF2-MDM2 axis sensitizes refractory acute myeloid leukemia to chemotherapy

(2018) Harinad B. Maganti et al.   Cancer Discovery

JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells

(2018) Hamza Celik et al.   CANCER CELL

CBX2 identified as driver of anoikis escape and dissemination in high grade serous ovarian cancer

(2018) Lindsay J. Wheeler et al.   Oncogenesis

Oncohistones: drivers of pediatric cancers

(2017) Faizaan Mohammad et al.   GENES & DEVELOPMENT

Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity

(2017) Wukui Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluating the Mechanism and Therapeutic Potential of PTC-028, a Novel Inhibitor of BMI-1 Function in Ovarian Cancer

(2017) Anindya Dey et al.   MOLECULAR CANCER THERAPEUTICS

Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription

(2017) M. Behfar Ardehali et al.   MOLECULAR CELL

Polycomb-like proteins link the PRC2 complex to CpG islands

(2017) Haojie Li et al.   NATURE

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

(2017) Wei Qi et al.   Nature Chemical Biology

The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

(2017) Yupeng He et al.   Nature Chemical Biology

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

(2017) Faizaan Mohammad et al.   NATURE MEDICINE

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

(2017) Andrea Piunti et al.   NATURE MEDICINE

PCGF3/5–PRC1 initiates Polycomb recruitment in X chromosome inactivation

(2017) Mafalda Almeida et al.   SCIENCE

Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity

(2016) Fulvio Chiacchiera et al.   Cell Stem Cell

Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs

(2016) Anne Grijzenhout et al.   DEVELOPMENT

Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis

(2016) Jaclyn Andricovich et al.   JOURNAL OF CLINICAL INVESTIGATION

EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape

(2016) Robert Liefke et al.   MOLECULAR CELL

EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells

(2016) Malte Beringer et al.   MOLECULAR CELL

High-throughput discovery of novel developmental phenotypes

(2016) Mary E. Dickinson et al.   NATURE

An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation

(2016) George P Souroullas et al.   NATURE MEDICINE

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

Epigenetic balance of gene expression by Polycomb and COMPASS families

(2016) Andrea Piunti et al.   SCIENCE

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

(2016) J. Bayliss et al.   Science Translational Medicine

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2

(2016) Sarah Cooper et al.   Nature Communications

A High-Density Map for Navigating the Human Polycomb Complexome

(2016) Simon Hauri et al.   Cell Reports

Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis

(2016) Vincent van den Boom et al.   Cell Reports

Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner

(2015) M. Mochizuki-Kashio et al.   BLOOD

An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3

(2015) Jovylyn Gatchalian et al.   Epigenetics

The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development

(2015) Robert S. Illingworth et al.   GENES & DEVELOPMENT

Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation

(2015) Ana Raquel Pengelly et al.   GENES & DEVELOPMENT

AEBP2 as a transcriptional activator and its role in cell migration

(2015) Hana Kim et al.   GENOMICS

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation

(2015) Serena Sanulli et al.   MOLECULAR CELL

FBXL10 protects Polycomb-bound genes from hypermethylation

(2015) Mathieu Boulard et al.   NATURE GENETICS

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

(2015) Kimberly H Kim et al.   NATURE MEDICINE

Loss of BAP1 function leads to EZH2-dependent transformation

(2015) Lindsay M LaFave et al.   NATURE MEDICINE

Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2

(2015) L. Jiao et al.   SCIENCE

Dual Roles of RNF2 in Melanoma Progression

(2015) K. Rai et al.   Cancer Discovery

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

(2014) Neil P. Blackledge et al.   CELL

An AUTS2–Polycomb complex activates gene expression in the CNS

(2014) Zhonghua Gao et al.   NATURE

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

(2014) Ming Zhang et al.   NATURE GENETICS

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors

(2014) William Lee et al.   NATURE GENETICS

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression

(2014) Reinhard Kalb et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purification

(2014) A. A. Alekseyenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pcgf6, a Polycomb Group Protein, Regulates Mesodermal Lineage Differentiation in Murine ESCs and Functions in iPS Reprogramming

(2014) D. Zdzieblo et al.   STEM CELLS

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

(2014) Andrea Piunti et al.   Nature Communications

Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts

(2014) Helen Pemberton et al.   GENOME BIOLOGY

EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

(2013) Wendy Béguelin et al.   CANCER CELL

Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

(2013) Sebastian Bender et al.   CANCER CELL

Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin

(2013) J. Son et al.   GENES & DEVELOPMENT

Identification of a novel, recurrentMBTD1-CXorf67fusion in low-grade endometrial stromal sarcoma

(2013) Barbara Dewaele et al.   INTERNATIONAL JOURNAL OF CANCER

Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation

(2013) Xudong Wu et al.   MOLECULAR CELL

Polycomb-Dependent H3K27me1 and H3K27me2 Regulate Active Transcription and Enhancer Fidelity

(2013) Karin J. Ferrari et al.   MOLECULAR CELL

Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation

(2013) Karin Klauke et al.   NATURE CELL BIOLOGY

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes

(2013) Jin He et al.   NATURE CELL BIOLOGY

Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer

(2013) Woojin Kim et al.   Nature Chemical Biology

Self-renewal as a therapeutic target in human colorectal cancer

(2013) Antonija Kreso et al.   NATURE MEDICINE

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

(2013) Gautier Koscielny et al.   NUCLEIC ACIDS RESEARCH

A Histone Mutant Reproduces the Phenotype Caused by Loss of Histone-Modifying Factor Polycomb

(2013) A. R. Pengelly et al.   SCIENCE

Recurrent Rearrangement of the PHF1 Gene in Ossifying Fibromyxoid Tumors

(2012) Samuel Gebre-Medhin et al.   AMERICAN JOURNAL OF PATHOLOGY

RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3

(2012) Lígia Tavares et al.   CELL

The Polycomb Group Protein L3mbtl2 Assembles an Atypical PRC1-Family Complex that Is Essential in Pluripotent Stem Cells and Early Development

(2012) Jinzhong Qin et al.   Cell Stem Cell

MicroRNA Regulation of Cbx7 Mediates a Switch of Polycomb Orthologs during ESC Differentiation

(2012) Ana O'Loghlen et al.   Cell Stem Cell

Nonoverlapping Functions of the Polycomb Group Cbx Family of Proteins in Embryonic Stem Cells

(2012) Lluis Morey et al.   Cell Stem Cell

Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo

(2012) Anne M. Boulet et al.   DEVELOPMENTAL BIOLOGY

Polycomb function during oogenesis is required for mouse embryonic development

(2012) E. Posfai et al.   GENES & DEVELOPMENT

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

(2012) C. Simon et al.   GENES & DEVELOPMENT

CBX7 is a tumor suppressor in mice and humans

(2012) Floriana Forzati et al.   JOURNAL OF CLINICAL INVESTIGATION

Lethal myelofibrosis induced byBmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes

(2012) Hideyuki Oguro et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PAX5-AUTS2: A recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia

(2012) Dagmar Denk et al.   LEUKEMIA RESEARCH

PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes

(2012) Zhonghua Gao et al.   MOLECULAR CELL

An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting

(2012) Ling Cai et al.   MOLECULAR CELL

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

(2012) Sarah K Knutson et al.   Nature Chemical Biology

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

(2012) Panagiotis Ntziachristos et al.   NATURE MEDICINE

Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity

(2012) Cecilia Ballaré et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation

(2012) Gerard L Brien et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1

(2012) Catherine A Musselman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RYBP and Cbx7 Define Specific Biological Functions of Polycomb Complexes in Mouse Embryonic Stem Cells

(2012) Lluis Morey et al.   Cell Reports

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

(2012) Anca M Farcas et al.   eLife

Frequency of Known Gene Rearrangements in Endometrial Stromal Tumors

(2011) Sarah Chiang et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Loss of Heterochromatin Protein 1 Gamma Reduces the Number of Primordial Germ Cells via Impaired Cell Cycle Progression in Mice1

(2011) Kanae Abe et al.   BIOLOGY OF REPRODUCTION

CBX8, a Polycomb Group Protein, Is Essential for MLL-AF9-Induced Leukemogenesis

(2011) Jiaying Tan et al.   CANCER CELL

Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex

(2011) Matthew L Bentley et al.   EMBO JOURNAL

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

(2011) E. Ezhkova et al.   GENES & DEVELOPMENT

Interaction Proteomics Analysis of Polycomb Proteins Defines Distinct PRC1 Complexes in Mammalian Cells

(2011) Julien Vandamme et al.   MOLECULAR & CELLULAR PROTEOMICS

L3MBTL2 Protein Acts in Concert with PcG Protein-Mediated Monoubiquitination of H2A to Establish a Repressive Chromatin Structure

(2011) Patrick Trojer et al.   MOLECULAR CELL

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

(2011) Frank W. Schmitges et al.   MOLECULAR CELL

Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

(2010) Boris G. Wilson et al.   CANCER CELL

Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation

(2010) Till Bartke et al.   CELL

Epigenetic factors in cancer development: Polycomb group proteins

(2010) Andrea Piunti et al.   Future Oncology

Jarid2 and PRC2, partners in regulating gene expression

(2010) G. Li et al.   GENES & DEVELOPMENT

Recognition and Specificity Determinants of the Human Cbx Chromodomains

(2010) Lilia Kaustov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAX5-AUTS2 fusion resulting from t(7;9)(q11.2;p13.2) can now be classified as recurrent in B cell acute lymphoblastic leukemia

(2010) E. Coyaud et al.   LEUKEMIA RESEARCH

Mammalian Polycomb-Like Pcl2/Mtf2 Is a Novel Regulatory Component of PRC2 That Can Differentially Modulate Polycomb Activity both at the Hox Gene Cluster and at Cdkn2a Genes

(2010) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Polycomb Group Protein Displacement and Gene Activation through MSK-Dependent H3K27me3S28 Phosphorylation

(2010) Simmi Suman Gehani et al.   MOLECULAR CELL

Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination

(2010) Ragnhild Eskeland et al.   MOLECULAR CELL

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

(2010) Diego Pasini et al.   NATURE

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

(2010) David Landeira et al.   NATURE CELL BIOLOGY

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

(2010) Gorica Nikoloski et al.   NATURE GENETICS

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

(2010) C. J. Sneeringer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRC2 Complexes with JARID2, MTF2, and esPRC2p48 in ES Cells to Modulate ES Cell Pluripotency and Somatic Cell Reprograming

(2010) Zhuo Zhang et al.   STEM CELLS

Polycomb Group Targeting through Different Binding Partners of RING1B C-Terminal Domain

(2010) Renjing Wang et al.   STRUCTURE

HP1γ function is required for male germ cell survival and spermatogenesis

(2010) Jeremy P Brown et al.   Epigenetics & Chromatin

Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells

(2009) Jamy C. Peng et al.   CELL

Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells

(2009) Xiaohua Shen et al.   CELL

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

Mel-18 Negatively Regulates INK4a/ARF-Independent Cell Cycle Progression via Akt Inactivation in Breast Cancer

(2008) J.-Y. Lee et al.   CANCER RESEARCH

Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity

(2008) M. Endoh et al.   DEVELOPMENT

dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing

(2008) A. Lagarou et al.   GENES & DEVELOPMENT

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL

A model for transmission of the H3K27me3 epigenetic mark

(2008) Klaus H. Hansen et al.   NATURE CELL BIOLOGY

Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46

(2008) Natalia V. Murzina et al.   STRUCTURE