Polyplex interaction strength as a driver of potency during cancer immunotherapy

In situ polymerization on biomacromolecules for nanomedicines

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Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy

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Improving Vaccine and Immunotherapy Design Using Biomaterials

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Self-Assembly of Immune Signals Improves Codelivery to Antigen Presenting Cells and Accelerates Signal Internalization, Processing Kinetics, and Immune Activation

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Impact of molecular weight on the intrinsic immunogenic activity of poly(beta amino esters)

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Self-replicating RNA vaccine functionality modulated by fine-tuning of polyplex delivery vehicle structure

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Development of fluorinated polyplex nanoemulsions for improved small interfering RNA delivery and cancer therapy

(2017) Gang Chen et al.   Nano Research

Biophysical Attributes of CpG Presentation Control TLR9 Signaling to Differentially Polarize Systemic Immune Responses

(2017) Jardin A. Leleux et al.   Cell Reports

Switching the Immunogenicity of Peptide Assemblies Using Surface Properties

(2016) Yi Wen et al.   ACS Nano

Intrinsic immunogenicity of rapidly-degradable polymers evolves during degradation

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Beyond antigens and adjuvants: formulating future vaccines

(2016) Tyson J. Moyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Designer vaccine nanodiscs for personalized cancer immunotherapy

(2016) Rui Kuai et al.   NATURE MATERIALS

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

(2016) Qian Chen et al.   Nature Communications

Improving the clinical impact of biomaterials in cancer immunotherapy

(2016) Joshua M. Gammon et al.   Oncotarget

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

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Presentation matters: Identity of gold nanocluster capping agent governs intracellular uptake and cell metabolism

(2014) Chor Yong Tay et al.   Nano Research

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Biomaterials for Nanoparticle Vaccine Delivery Systems

(2014) Preety Sahdev et al.   PHARMACEUTICAL RESEARCH

Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

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Selectively targeting the toll-like receptor 9 (TLR9) – IRF 7 signaling pathway by polymer blend particles

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Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response

(2013) Susan N. Thomas et al.   BIOMATERIALS

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer

(2013) Charles G. Drake et al.   Nature Reviews Clinical Oncology

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Electrostatic surface modifications to improve gene delivery

(2010) Ron B Shmueli et al.   Expert Opinion on Drug Delivery

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY