Inhibitory Receptors and Pathways of Lymphocytes: The Role of PD-1 in Treg Development and Their Involvement in Autoimmunity Onset and Cancer Progression

The “Three Amigos” lurking behind type 1 diabetes: Hygiene, gut microbiota and viruses

(2018) Odin Andreas Johan Jakobsen et al.   ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA

Survival of the fittest: Cancer challenges T cell metabolism

(2018) Davide G. Franchina et al.   CANCER LETTERS

Collective effects of common single nucleotide polymorphisms and genetic risk prediction in type 1 diabetes

(2018) Y. Gui et al.   CLINICAL GENETICS

Reduction in Regulatory T Cells in Early Pregnancy Causes Uterine Artery Dysfunction in MiceNovelty and Significance

(2018) Alison S. Care et al.   HYPERTENSION

Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors

(2018) Kristian M. Hargadon et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Type 1 Diabetes and Its Multi-Factorial Pathogenesis: The Putative Role of NK Cells

(2018) Valeria Marca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intestinal IFN-γ–producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease

(2018) Johanna Sophie Alfen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Self-Delivering RNAi Targeting PD-1 Improves Tumor-Specific T Cell Functionality for Adoptive Cell Therapy of Malignant Melanoma

(2018) Maarten A. Ligtenberg et al.   MOLECULAR THERAPY

The Clinical Activity of PD-1/PD-L1 Inhibitors in Metastatic Non–Clear Cell Renal Cell Carcinoma

(2018) Rana R. McKay et al.   Cancer Immunology Research

Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus

(2018) Susan Malkiel et al.   Frontiers in Immunology

PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin

(2018) Xiao Miao et al.   Scientific Reports

The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part I: Treg properties and functions

(2017) Bogusław Nedoszytko et al.   Postepy Dermatologii i Alergologii

Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab

(2016) A. M. Menzies et al.   ANNALS OF ONCOLOGY

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

(2016) Y. Lou et al.   CLINICAL CANCER RESEARCH

Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy

(2016) Weijie Ma et al.   Journal of Hematology & Oncology

Expanding the List of Dysregulated Immunosuppressive Cells in Psoriasis

(2016) David C. Soler et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination

(2016) Celine Boutros et al.   Nature Reviews Clinical Oncology

Recent Insight into the Role of the PD-1/PD-L1 Pathway in Feto-Maternal Tolerance and Pregnancy

(2015) Yong-Hong Zhang et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Programmed death-ligand 1, 2 expressions are decreased in the psoriatic epidermis

(2015) Dae Suk Kim et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Control of PD-L1 Expression by Oncogenic Activation of the AKT–mTOR Pathway in Non–Small Cell Lung Cancer

(2015) Kristin J. Lastwika et al.   CANCER RESEARCH

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

(2015) Sonja Kleffel et al.   CELL

Induction of PD-L1 Expression by the EML4-ALK Oncoprotein and Downstream Signaling Pathways in Non-Small Cell Lung Cancer

(2015) K. Ota et al.   CLINICAL CANCER RESEARCH

The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma

(2015) Kathleen M. Mahoney et al.   CLINICAL THERAPEUTICS

Anti–PD-1 and Anti–PDL-1 Monoclonal Antibodies Causing Type 1 Diabetes

(2015) Mahnaz Mellati et al.   DIABETES CARE

Expression of PD-1 Molecule on Regulatory T Lymphocytes in Patients with Insulin-Dependent Diabetes Mellitus

(2015) Valentina Perri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8+T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8+T Cells

(2015) Hyo Jin Park et al.   JOURNAL OF IMMUNOLOGY

Upregulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-Driven NSCLC: Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation

(2015) Nan Chen et al.   Journal of Thoracic Oncology

Psoriasis

(2015) Wolf-Henning Boehncke et al.   LANCET

Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma

(2015) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities

(2015) F. Skoulidis et al.   Cancer Discovery

Adaptive Immune Resistance: How Cancer Protects from Immune Attack

(2015) A. Ribas   Cancer Discovery

Role of PD1/PDL1 pathway, and TH17 and treg cells in maternal tolerance to the fetus

(2015) Indira Guleria et al.   Biomedical Journal

Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer

(2014) K. Azuma et al.   ANNALS OF ONCOLOGY

Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus

(2014) D. Mesquita Júnior et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Programmed Cell Death 1 (PD-1) and Its Ligand (PD-L1) in Common Cancers and Their Correlation with Molecular Cancer Type

(2014) Z. Gatalica et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The immunology of pregnancy: Regulatory T cells control maternal immune tolerance toward the fetus

(2014) Claudia La Rocca et al.   IMMUNOLOGY LETTERS

Programmed cell death 1 (PD-1) regulates the effector function of CD8 T cells via PD-L1 expressed on target keratinocytes

(2014) Naoko Okiyama et al.   JOURNAL OF AUTOIMMUNITY

CTLA4 Expression Is an Indicator and Regulator of Steady-State CD4+FoxP3+ T Cell Homeostasis

(2014) A. L. Tang et al.   JOURNAL OF IMMUNOLOGY

Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade

(2014) Janis M Taube   OncoImmunology

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment

(2014) Stefani Spranger et al.   Journal for ImmunoTherapy of Cancer

Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity

(2013) Elena Gianchecchi et al.   AUTOIMMUNITY REVIEWS

Blockade of Programmed Death-1 in Young (New Zealand Black x New Zealand White)F1 Mice Promotes the Suppressive Capacity of CD4+ Regulatory T Cells Protecting from Lupus-like Disease

(2013) M. Wong et al.   JOURNAL OF IMMUNOLOGY

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor-infiltrating regulatory T cells delineated by upregulation of PD-1 and inhibitory receptors

(2012) Hyo Jin Park et al.   CELLULAR IMMUNOLOGY

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo

(2012) J. Gotot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low Circulating CD4+ CD25+ Foxp3+ T Regulatory Cell Levels Predict Miscarriage Risk in Newly Pregnant Women with a History of Failure

(2011) Edward E. Winger et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

(2011) Q. Zhou et al.   BLOOD

Antitumor and immunomodulatory properties of artemether and its ability to reduce CD4+ CD25+ FoxP3+ T reg cells in vivo

(2011) Vida Farsam et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Six Decades of Vitiligo Genetics: Genome-Wide Studies Provide Insights into Autoimmune Pathogenesis

(2011) Richard A. Spritz   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Regulatory T Cells Stimulate B7-H1 Expression in Myeloid-Derived Suppressor Cells in ret Melanomas

(2011) Taku Fujimura et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vitiligo: A comprehensive overview

(2011) Ali Alikhan et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

(2011) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

The PDL1-PD1 Axis Converts Human TH1 Cells into Regulatory T Cells

(2011) S. Amarnath et al.   Science Translational Medicine

Two modes of immune suppression by Foxp3+ regulatory T cells under inflammatory or non-inflammatory conditions

(2011) Tomoyuki Yamaguchi et al.   SEMINARS IN IMMUNOLOGY

Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma

(2010) Ryosuke Hino et al.   CANCER

Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals

(2010) J. Mitsui et al.   CLINICAL CANCER RESEARCH

The potential of multimer technologies in type 1 diabetes prediction strategies

(2010) Alessandra Fierabracci   DIABETES-METABOLISM RESEARCH AND REVIEWS

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

PD-1 deficiency results in the development of fatal myocarditis in MRL mice

(2010) Jian Wang et al.   INTERNATIONAL IMMUNOLOGY

Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

(2010) Julie R. Brahmer et al.   JOURNAL OF CLINICAL ONCOLOGY

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endothelial Cells Augment the Suppressive Function of CD4+CD25+Foxp3+ Regulatory T Cells: Involvement of Programmed Death-1 and IL-10

(2010) T. Bedke et al.   JOURNAL OF IMMUNOLOGY

Tumor-infiltrating NY-ESO-1–specific CD8+T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer

(2010) Junko Matsuzaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

(2009) M. Ahmadzadeh et al.   BLOOD

Profile of Tumor Antigen-Specific CD8 T Cells in Patients With Hepatitis B Virus-Related Hepatocellular Carcinoma

(2009) Adam J. Gehring et al.   GASTROENTEROLOGY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Regulatory T Cells Do Not Require Stimulation through Their TCR to Suppress

(2009) A. L. Szymczak-Workman et al.   JOURNAL OF IMMUNOLOGY

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

(2008) Qizhi Tang et al.   NATURE IMMUNOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology