TCR Signal Strength Regulates Akt Substrate Specificity To Induce Alternate Murine Th and T Regulatory Cell Differentiation Programs

T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity

(2015) Vaishali R. Moulton et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Differential Regulation of PTEN by TCR, Akt, and FoxO1 Controls CD4+T Cell Fate Decisions

(2015) William F. Hawse et al.   JOURNAL OF IMMUNOLOGY

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

(2015) Sharad Shrestha et al.   NATURE IMMUNOLOGY

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3

(2015) Dapeng Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low TCR signal strength induces combined expansion of Th2 and regulatory T cell populations that protect mice from the development of type 1 diabetes

(2014) Michael S. Turner et al.   DIABETOLOGIA

hnRNP U Enhances Caspase-9 Splicing and Is Modulated by AKT-dependent Phosphorylation of hnRNP L

(2013) Ngoc T. Vu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptome-Wide RNA Interaction Profiling Reveals Physical and Functional Targets of hnRNP L in Human T Cells

(2013) G. Shankarling et al.   MOLECULAR AND CELLULAR BIOLOGY

HnRNP L and HnRNP A1 Induce Extended U1 snRNA Interactions with an Exon to Repress Spliceosome Assembly

(2013) Ni-Ting Chiou et al.   MOLECULAR CELL

Large-scale gene function analysis with the PANTHER classification system

(2013) Huaiyu Mi et al.   Nature Protocols

The Duration of T Cell Stimulation Is a Critical Determinant of Cell Fate and Plasticity

(2013) N. Miskov-Zivanov et al.   Science Signaling

Alternative Splicing Controlled by Heterogeneous Nuclear Ribonucleoprotein L Regulates Development, Proliferation, and Migration of Thymic Pre-T Cells

(2012) M.-C. Gaudreau et al.   JOURNAL OF IMMUNOLOGY

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Xiaoqing Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative Splicing Factor/Splicing Factor 2 Regulates the Expression of the ζ Subunit of the Human T Cell Receptor-associated CD3 Complex

(2010) Vaishali R. Moulton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases

(2010) A. Moritz et al.   Science Signaling

Dominant Role of Antigen Dose in CD4+Foxp3+ Regulatory T Cell Induction and Expansion

(2009) M. S. Turner et al.   JOURNAL OF IMMUNOLOGY

Alternative Splicing Modulates Autoinhibition and SH3 Accessibility in the Src Kinase Fyn

(2009) C. Brignatz et al.   MOLECULAR AND CELLULAR BIOLOGY

Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1

(2009) C. C. Dibble et al.   MOLECULAR AND CELLULAR BIOLOGY

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Memory T Cell RNA Rearrangement Programmed by Heterogeneous Nuclear Ribonucleoprotein hnRNPLL

(2008) Zuopeng Wu et al.   IMMUNITY

Heterogeneous Nuclear Ribonucleoprotein A1 Regulates Cyclin D1 and c-mycInternal Ribosome Entry Site Function through Akt Signaling

(2008) Oak D. Jo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA