Diversity in the origins of proteostasis networks — a driver for protein function in evolution

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

Signaling the mitochondrial unfolded protein response

(2012) Mark W. Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Physiological and pathological role of the ubiquitin-proteasome system in the vascular smooth muscle cell

(2012) M. Demasi et al.   CARDIOVASCULAR RESEARCH

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

Mechanisms of Autophagosome Biogenesis

(2012) David C. Rubinsztein et al.   CURRENT BIOLOGY

Proteostasis, an Emerging Therapeutic Paradigm for Managing Inflammatory Airway Stress Disease

(2012) M. Bouchecareilh et al.   CURRENT MOLECULAR MEDICINE

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

(2012) David Vilchez et al.   NATURE

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis

(2011) Sandro Santagata et al.   ACS Chemical Biology

Protein Folding and Modification in the Mammalian Endoplasmic Reticulum

(2011) Ineke Braakman et al.   Annual Review of Biochemistry

Structure, Mechanism, and Evolution of Ero1 Family Enzymes

(2011) Kazutaka Araki et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Broad action of Hsp90 as a host chaperone required for viral replication

(2011) Ron Geller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The endosome–lysosome pathway and information generation in the immune system

(2011) Colin Watts   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Specific functions of lysosomal proteases in endocytic and autophagic pathways

(2011) Sabrina Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

How Do Thermophilic Proteins and Proteomes Withstand High Temperature?

(2011) Lucas Sawle et al.   BIOPHYSICAL JOURNAL

Organization and evolution of hsp70clusters strikingly differ in two species of Stratiomyidae (Diptera) inhabiting thermally contrasting environments

(2011) David G Garbuz et al.   BMC EVOLUTIONARY BIOLOGY

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Endoplasmic Reticulum Stress in theβ-Cell Pathogenesis of Type 2 Diabetes

(2011) Sung Hoon Back et al.   Experimental Diabetes Research

Differential Expression of Small Heat Shock Protein Genes Hsp23 and Hsp40, and heat shock gene Hsr-omega in Fruit Flies (Drosophila melanogaster) along a Microclimatic Gradient

(2011) J. Carmel et al.   JOURNAL OF HEREDITY

Contribution of Hydrophobic Interactions to Protein Stability

(2011) C. Nick Pace et al.   JOURNAL OF MOLECULAR BIOLOGY

Thermal adaptation and ecological speciation

(2011) I. KELLER et al.   MOLECULAR ECOLOGY

Protection from the outside

(2011) Evan T. Powers et al.   NATURE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

(2011) Allan M. Weissman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Functional Organization of hsp70 Cluster in Camel (Camelus dromedarius) and Other Mammals

(2011) David G. Garbuz et al.   PLoS One

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Endosomal transport via ubiquitination

(2011) Robert C. Piper et al.   TRENDS IN CELL BIOLOGY

The Stress of Protein Misfolding: From Single Cells to Multicellular Organisms

(2011) T. Gidalevitz et al.   Cold Spring Harbor Perspectives in Biology

Chemical and Biological Approaches for Adapting Proteostasis to Ameliorate Protein Misfolding and Aggregation Diseases-Progress and Prognosis

(2011) S. L. Lindquist et al.   Cold Spring Harbor Perspectives in Biology

Cellular Strategies of Protein Quality Control

(2011) B. Chen et al.   Cold Spring Harbor Perspectives in Biology

A Chaperonin Subunit with Unique Structures Is Essential for Folding of a Specific Substrate

(2011) Lianwei Peng et al.   PLOS BIOLOGY

At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways

(2010) Gian Paolo Fadini et al.   AGING CELL

Protein Homeostasis and the Phenotypic Manifestation of Genetic Diversity: Principles and Mechanisms

(2010) Daniel F. Jarosz et al.   Annual Review of Genetics

Cellular Proteomes Have Broad Distributions of Protein Stability

(2010) Kingshuk Ghosh et al.   BIOPHYSICAL JOURNAL

Chemical and/or biological therapeutic strategies to ameliorate protein misfolding diseases

(2010) Derrick Sek Tong Ong et al.   CURRENT OPINION IN CELL BIOLOGY

A systematic survey of in vivo obligate chaperonin-dependent substrates

(2010) Kei Fujiwara et al.   EMBO JOURNAL

The Effect of Chaperonin Buffering on Protein Evolution

(2010) Tom A. Williams et al.   Genome Biology and Evolution

Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

(2010) Mikael Altun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

Variation in the heat shock response and its implication for predicting the effect of global climate change on species' biogeographical distribution ranges and metabolic costs

(2010) L. Tomanek   JOURNAL OF EXPERIMENTAL BIOLOGY

A DNAJB Chaperone Subfamily with HDAC-Dependent Activities Suppresses Toxic Protein Aggregation

(2010) Jurre Hageman et al.   MOLECULAR CELL

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons

(2010) Valeria Specchia et al.   NATURE

The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase

(2010) Sandeep K Sharma et al.   Nature Chemical Biology

n→π* interactions in proteins

(2010) Gail J Bartlett et al.   Nature Chemical Biology

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chaperone networks: Tipping the balance in protein folding diseases

(2010) Cindy Voisine et al.   NEUROBIOLOGY OF DISEASE

Heat shock proteins in chronic kidney disease

(2010) Kinga Musiał et al.   PEDIATRIC NEPHROLOGY

Phylogeny Disambiguates the Evolution of Heat-Shock cis-Regulatory Elements in Drosophila

(2010) Sibo Tian et al.   PLoS One

On the evolutionary origin of the chaperonins

(2010) Carien Dekker et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation

(2010) D. F. Jarosz et al.   SCIENCE

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Oxidative Protein Folding in the Secretory Pathway and Redox Signaling Across Compartments and Cells

(2010) Éva Margittai et al.   TRAFFIC

HSP90 manages the ends

(2010) Diane C. DeZwaan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Emergent Properties of Proteostasis in Managing Cystic Fibrosis

(2010) W. E. Balch et al.   Cold Spring Harbor Perspectives in Biology

How do proteins gain new domains?

(2010) Joseph A Marsh et al.   GENOME BIOLOGY

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors

(2009) Olga Ostrovsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Stability effects of mutations and protein evolvability

(2009) Nobuhiko Tokuriki et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Inhibiting the transcription factor HSF1 as an anticancer strategy

(2009) Luke Whitesell et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The proteostasis boundary in misfolding diseases of membrane traffic

(2009) Darren M. Hutt et al.   FEBS LETTERS

The role of molecular chaperones in human misfolding diseases

(2009) Sarah A. Broadley et al.   FEBS LETTERS

Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation

(2009) Zoya Marinova et al.   JOURNAL OF NEUROCHEMISTRY

Protein Homeostasis and Aging: Taking Care of Proteins From the Cradle to the Grave

(2009) R. I. Morimoto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

HSP70 heat shock proteins and environmental stress in Antarctic marine organisms: A mini-review

(2009) Melody S. Clark et al.   Marine Genomics

Chaperonin overexpression promotes genetic variation and enzyme evolution

(2009) Nobuhiko Tokuriki et al.   NATURE

Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression

(2009) M. Tariq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Dynamism and Evolvability

(2009) N. Tokuriki et al.   SCIENCE

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

The Evolutionary Mechanics of Domain Organization in Proteomes and the Rise of Modularity in the Protein World

(2009) Minglei Wang et al.   STRUCTURE

Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity

(2009) Tali Gidalevitz et al.   PLoS Genetics

Structure and Energetics of the Hydrogen-Bonded Backbone in Protein Folding

(2008) D. Wayne Bolen et al.   Annual Review of Biochemistry

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

(2008) Luciano Brocchieri et al.   BMC EVOLUTIONARY BIOLOGY

Unique Contacts Direct High-Priority Recognition of the Tetrameric Mu Transposase-DNA Complex by the AAA+ Unfoldase ClpX

(2008) Aliaa H. Abdelhakim et al.   MOLECULAR CELL

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

Cpn20: Siamese twins of the chaperonin world

(2008) Celeste Weiss et al.   PLANT MOLECULAR BIOLOGY

Molecular signatures of ribosomal evolution

(2008) E. Roberts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons

(2008) V. Prahlad et al.   SCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Do viral proteins possess unique biophysical features?

(2008) Nobuhiko Tokuriki et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hsp104 and ClpB: protein disaggregating machines

(2008) Shannon M. Doyle et al.   TRENDS IN BIOCHEMICAL SCIENCES