Structural basis of translation termination, rescue, and recycling in mammalian mitochondria

Mechanisms and regulation of protein synthesis in mitochondria

(2021) Eva Kummer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural insights into mammalian mitochondrial translation elongation catalyzed by mt EFG 1

(2020) Eva Kummer et al.   EMBO JOURNAL

Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation

(2020) Ravi Kiran Koripella et al.   Nature Communications

Distinct pre-initiation steps in human mitochondrial translation

(2020) Anas Khawaja et al.   Nature Communications

Mechanism of ribosome rescue by alternative ribosome-rescue factor B

(2020) Kai-Hsin Chan et al.   Nature Communications

Structural basis of mitochondrial translation

(2020) Shintaro Aibara et al.   eLife

Elongational stalling activates mitoribosome-associated quality control

(2020) Nirupa Desai et al.   SCIENCE

Structural insights into unique features of the human mitochondrial ribosome recycling

(2019) Ravi K. Koripella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for ribosome recycling by RRF and tRNA

(2019) Dejian Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fidelity of translation initiation is required for coordinated respiratory complex assembly

(2019) Danielle L. Rudler et al.   Science Advances

Conformational Control of Translation Termination on the 70S Ribosome

(2018) Egor Svidritskiy et al.   STRUCTURE

MiR-1301-3p inhibits human breast cancer cell proliferation by regulating cell cycle progression and apoptosis through directly targeting ICT1

(2018) Xiang Peng et al.   Breast Cancer

Translation in Prokaryotes

(2018) Marina V. Rodnina   Cold Spring Harbor Perspectives in Biology

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM

(2018) Eva Kummer et al.   NATURE

Biological and Evolutionary Significance of Terminal Extensions of Mitochondrial Translation Initiation Factor 3

(2018) Ksenia Derbikova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Structures of translationally inactive mammalian ribosomes

(2018) Alan Brown et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Immature Colon Carcinoma Transcript-1 (ICT1) Expression Correlates with Unfavorable Prognosis and Survival in Patients with Colorectal Cancer

(2016) Xinyuan Lao et al.   ANNALS OF SURGICAL ONCOLOGY

Organization and Regulation of Mitochondrial Protein Synthesis

(2016) Martin Ott et al.   Annual Review of Biochemistry

Structural Basis for Translation Termination on a Pseudouridylated Stop Codon

(2016) Egor Svidritskiy et al.   JOURNAL OF MOLECULAR BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Key Intermediates in Ribosome Recycling Visualized by Time-Resolved Cryoelectron Microscopy

(2016) Ziao Fu et al.   STRUCTURE

Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria

(2016) Heather A. Feaga et al.   PLoS Genetics

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Mechanisms of ribosome rescue in bacteria

(2015) Kenneth C. Keiler   NATURE REVIEWS MICROBIOLOGY

The complete structure of the 55S mammalian mitochondrial ribosome

(2015) B. J. Greber et al.   SCIENCE

The structure of the human mitochondrial ribosome

(2015) A. Amunts et al.   SCIENCE

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

(2015) Timothy Grant et al.   eLife

Delineation of C12orf65-related phenotypes: a genotype–phenotype relationship

(2014) Ronen Spiegel et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Screening of Critical Genes in Lung Adenocarcinoma via Network Analysis of Gene Expression Profile

(2014) Ping Huang et al.   PATHOLOGY & ONCOLOGY RESEARCH

Structure of the large ribosomal subunit from human mitochondria

(2014) A. Brown et al.   SCIENCE

Ribosome Rescue and Translation Termination at Non-Standard Stop Codons by ICT1 in Mammalian Mitochondria

(2014) Shiori Akabane et al.   PLoS Genetics

Overcoming stalled translation in human mitochondria

(2014) Maria T. Wesolowska et al.   Frontiers in Microbiology

Novel C12orf65 mutations in patients with axonal neuropathy and optic atrophy

(2013) A. Tucci et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Architecture of the large subunit of the mammalian mitochondrial ribosome

(2013) Basil J. Greber et al.   NATURE

Identification of residues required for stalled-ribosome rescue in the codon-independent release factor YaeJ

(2013) H. Kogure et al.   NUCLEIC ACIDS RESEARCH

Solution structure and siRNA-mediated knockdown analysis of the mitochondrial disease-related protein C12orf65

(2013) Hiroyuki Kogure et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons

(2013) Christoffer Lind et al.   Nature Communications

Structure based hypothesis of a mitochondrial ribosome rescue mechanism

(2012) Martijn A Huynen et al.   Biology Direct

A homozygous mutation ofC12orf65causes spastic paraplegia with optic atrophy and neuropathy (SPG55)

(2012) Haruo Shimazaki et al.   JOURNAL OF MEDICAL GENETICS

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Structural Basis for the Rescue of Stalled Ribosomes: Structure of YaeJ Bound to the Ribosome

(2012) M. G. Gagnon et al.   SCIENCE

Structures of the Bacterial Ribosome in Classical and Hybrid States of tRNA Binding

(2011) J. A. Dunkle et al.   SCIENCE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mutations in C12orf65 in Patients with Encephalomyopathy and a Mitochondrial Translation Defect

(2010) Hana Antonicka et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Recognition of the amber UAG stop codon by release factor RF1

(2010) Andrei Korostelev et al.   EMBO JOURNAL

A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome

(2010) Ricarda Richter et al.   EMBO JOURNAL

Solution Structure of the Catalytic Domain of the Mitochondrial Protein ICT1 That Is Essential for Cell Vitality

(2010) Yoshihiro Handa et al.   JOURNAL OF MOLECULAR BIOLOGY

A bacterial elongation factor G homologue exclusively functions in ribosome recycling in the spirochaeteBorrelia burgdorferi

(2010) Takuma Suematsu et al.   MOLECULAR MICROBIOLOGY

Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria

(2010) D. J. Young et al.   RNA

Hungry Codons Promote Frameshifting in Human Mitochondrial Ribosomes

(2010) R. Temperley et al.   SCIENCE

Evidence for an Active Role of IF3mtin the Initiation of Translation in Mammalian Mitochondria†

(2009) Brooke E. Christian et al.   BIOCHEMISTRY

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

EF-G2mt Is an Exclusive Recycling Factor in Mammalian Mitochondrial Protein Synthesis

(2009) Masafumi Tsuboi et al.   MOLECULAR CELL

HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG

(2008) Yusuke Nozaki et al.   GENES TO CELLS

Structural basis for translation termination on the 70S ribosome

(2008) Martin Laurberg et al.   NATURE

The human mitochondrial ribosome recycling factor is essential for cell viability

(2008) Joanna Rorbach et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of a translation termination complex formed with release factor RF2

(2008) A. Korostelev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome

(2008) A. Weixlbaumer et al.   SCIENCE