Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer’s Disease

A Glimpse into Green Chemistry Practices in the Pharmaceutical Industry

(2020) Sudripet Sharma et al.   ChemSusChem

Translational Scoring of Candidate Treatments for Alzheimer’s Disease: A Systematic Approach

(2020) Jeffrey L. Cummings   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Coffee silverskin extracts: Quantification of 30 bioactive compounds by a new HPLC-MS/MS method and evaluation of their antioxidant and antibacterial activities

(2020) Franks Kamgang Nzekoue et al.   FOOD RESEARCH INTERNATIONAL

Discovery and biological evaluation of a novel highly potent selective butyrylcholinsterase inhibitor

(2020) Qi Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fruit Quality Characterization of New Sweet Cherry Cultivars as a Good Source of Bioactive Phenolic Compounds with Antioxidant and Neuroprotective Potential

(2020) Fabiana Antognoni et al.   Antioxidants

From hybrids to new scaffolds: the latest medicinal chemistry goals in multi-target directed ligands for Alzheimer’s disease

(2020) Jazmín Alarcón-Espósito et al.   Current Neuropharmacology

Structure and therapeutic uses of butyrylcholinesterase: Application in detoxification, Alzheimer's disease, and fat metabolism

(2020) Shuaishuai Xing et al.   MEDICINAL RESEARCH REVIEWS

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

(2020) Elisabet Viayna et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Signaling mechanisms underlying inhibition of neuroinflammation by resveratrol in neurodegenerative diseases

(2020) Juan Huang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Novel sustainable-by-design HDAC inhibitors for the treatment of Alzheimer’s disease

(2019) Luiz A. S. Romeiro et al.   ACS Medicinal Chemistry Letters

Harnessing Polypharmacology with Medicinal Chemistry

(2019) Maria Laura Bolognesi   ACS Medicinal Chemistry Letters

The TSPO Ligands 2-Cl-MGV-1, MGV-1, and PK11195 Differentially Suppress the Inflammatory Response of BV-2 Microglial Cell to LPS

(2019) Maya Azrad et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms

(2019) Junting Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease

(2019) Francesco Mesiti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer’s Disease Mouse Model

(2019) Matthias Hoffmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer’s Agents

(2018) Dawid Panek et al.   ACS Chemical Neuroscience

Molecular evaluation of anti-inflammatory activity of phenolic lipid extracted from cashew nut shell liquid (CNSL)

(2018) Marilen Queiroz de Souza et al.   BMC Complementary and Alternative Medicine

Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer’s Disease: Mechanisms, Drug Candidates, and New Opportunities

(2018) Wing-Yu Fu et al.   ACS Chemical Neuroscience

A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease

(2017) Bilqees Sameem et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

(2017) Urban Košak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study

(2017) Terrone Rosenberry et al.   MOLECULES

Expanding the biomass derived chemical space

(2017) Nicolas Brun et al.   Chemical Science

Polder maps: improving OMIT maps by excluding bulk solvent

(2017) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease

(2016) Laís Flávia Nunes Lemes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CHEM21 selection guide of classical- and less classical-solvents

(2016) Denis Prat et al.   GREEN CHEMISTRY

Discovery and Structure–Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening

(2016) Satish N. Dighe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug development in Alzheimer’s disease: the path to 2025

(2016) Jeffrey Cummings et al.   Alzheimers Research & Therapy

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

(2015) Eugenie Nepovimova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Innate Immune Response in Brain, NF-Kappa B Signaling and Cystatins

(2015) Nataša Kopitar-Jerala   Frontiers in Molecular Neuroscience

Selective Acetyl- and Butyrylcholinesterase Inhibitors Reduce Amyloid-β Ex Vivo Activation of Peripheral Chemo-cytokines From Alzheimer’s Disease Subjects: Exploring the Cholinergic Anti-inflammatory Pathway

(2014) Marcella Reale et al.   Current Alzheimer Research

Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects

(2014) Eugenie Nepovimova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia

(2014) Olumayokun A. Olajide et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Microglial Dynamics and Role in the Healthy and Diseased Brain

(2014) Diego Gomez-Nicola et al.   NEUROSCIENTIST

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

(2013) Florian Nachon et al.   BIOCHEMICAL JOURNAL

Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer’s disease

(2013) Alejandro Romero et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Resurrection of 7-MEOTA: A Comparison with Tacrine

(2013) Ondrej Soukup et al.   Current Alzheimer Research

Design, synthesis and evaluation of novel tacrine–coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease

(2013) Sai-Sai Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease

(2013) Taher Darreh-Shori et al.   NEUROBIOLOGY OF AGING

Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation

(2013) Stefania Butini et al.   ACS Medicinal Chemistry Letters

Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure

(2012) Xavier Brazzolotto et al.   FEBS Journal

Tacrine-Silibinin Codrug Shows Neuro- and Hepatoprotective Effects in Vitro and Pro-Cognitive and Hepatoprotective Effects in Vivo

(2012) Xinyu Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

(2012) Jose Miguel Rubio-Perez et al.   TheScientificWorldJOURNAL

Emerging Roles of Anacardic Acid and Its Derivatives: A Pharmacological Overview

(2011) Mahadevappa Hemshekhar et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

electronic Ligand Builder and Optimization Workbench(eLBOW): a tool for ligand coordinate and restraint generation

(2009) Nigel W. Moriarty et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research

(2009) Sang-Ho Choi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: Evidence for uncoupled regulation of mPGES-1 and COX-2

(2008) Antonio Carlos Pinheiro de Oliveira et al.   GLIA

Study of technical CNSL and its main components as new green larvicides

(2008) Diego Lomonaco et al.   GREEN CHEMISTRY

Synthesis and Biological Evaluation of NO-Donor-Tacrine Hybrids as Hepatoprotective Anti-Alzheimer Drug Candidates

(2008) Lei Fang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology