The protective effect of Veronica ciliata Fisch. Extracts on relieving oxidative stress-induced liver injury via activating AMPK/p62/Nrf2 pathway

Effect of Anoectochilus roxburghii flavonoids extract on oxidative stress in LO2 cells induced by H2O2 and D-gal induced aging mouse model1

(2020) Liping Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage

(2020) Xin Tan et al.   Frontiers in Pharmacology

Hepatoprotective effects of total phenylethanoid glycosides from Acanthus ilicifolius L. against carbon tetrachloride-induced hepatotoxicity

(2020) Meng-Qi Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Enhanced Keap1-Nrf2/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1/JNK and Txnip/NLRP3 inflammasome activation

(2020) Hongming Lv et al.   PHYTOMEDICINE

Hyperoside Protected Against Oxidative Stress-Induced Liver Injury via the PHLPP2-AKT-GSK-3β Signaling Pathway In Vivo and In Vitro

(2020) Haiyan Xing et al.   Frontiers in Pharmacology

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

(2019) Ziwen Wang et al.   Nature Communications

Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway

(2019) Qiuxia Lu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Procyanidin A2 penetrates L-02 cells and protects against tert-butyl hydroperoxide-induced oxidative stress by activating Nrf2 through JNK and p38 phosphorylation

(2019) Hai-Yan Xu et al.   Journal of Functional Foods

Caffeic acid inhibits HCV replication via induction of IFNα antiviral response through p62-mediated Keap1/Nrf2 signaling pathway

(2018) Jian Shen et al.   ANTIVIRAL RESEARCH

Grape seed procyanidin extract protects against Pb-induced lung toxicity by activating the AMPK/Nrf2/p62 signaling axis

(2018) Jingjing Lu et al.   FOOD AND CHEMICAL TOXICOLOGY

Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349

(2018) Xiaohui Su et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phenolic acid and flavonoid-rich fraction of Sasa quelpaertensis Nakai leaves prevent alcohol induced fatty liver through AMPK activation

(2018) Kalahe Hewage Iresha Nadeeka Madushani Herath et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-inflammatory sesquiterpenoids from the Traditional Chinese Medicine Salvia plebeia : Regulates pro-inflammatory mediators through inhibition of NF-κB and Erk1/2 signaling pathways in LPS-induced Raw264.7 cells

(2018) Yi-Hong Zou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protective effect of a rosmarinic acid-rich extract from cold-pressed Perilla frutescens seed flour on oxidative hepatotoxicity in vitro and in vivo

(2018) Yajie Zhang et al.   JOURNAL OF FOOD BIOCHEMISTRY

Nrf2 in alcoholic liver disease

(2018) Jing Sun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Biological Effect of Licochalcone C on the Regulation of PI3K/Akt/eNOS and NF-κB/iNOS/NO Signaling Pathways in H9c2 Cells in Response to LPS Stimulation

(2017) Sara Franceschelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective Effect of Camellia Oil (Camellia oleifera Abel.) against Ethanol-Induced Acute Oxidative Injury of the Gastric Mucosa in Mice

(2017) Pang-Shuo Tu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury

(2017) Ping Qiu et al.   TOXICOLOGY LETTERS

Dietary luteolin attenuates chronic liver injury induced by mercuric chloride via the Nrf2/NF-κB/P53 signaling pathway in rats

(2017) Haili Zhang et al.   Oncotarget

Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata

(2016) Li Yin et al.   Chemistry Central Journal

Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation of Nrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells

(2016) Chongshan Dai et al.   FOOD AND CHEMICAL TOXICOLOGY

Structure–antioxidant activity relationships of o-hydroxyl, o-methoxy, and alkyl ester derivatives of p-hydroxybenzoic acid

(2016) Reza Farhoosh et al.   FOOD CHEMISTRY

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

(2016) Da Hyun Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic Fate of Luteolin in Rats: Its Relationship to Anti-inflammatory Effect

(2016) Ayako Kure et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

(2016) Kimberly O. Cameron et al.   JOURNAL OF MEDICINAL CHEMISTRY

HSCCC Separation of the Two Iridoid Glycosides and Three Phenolic Compounds from Veronica ciliata and Their in Vitro Antioxidant and Anti-Hepatocarcinoma Activities

(2016) Qiuxia Lu et al.   MOLECULES

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

(2016) Tetsuya Saito et al.   Nature Communications

Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects

(2016) Hua Zhang et al.   Current Opinion in Food Science

Regulation of Sirt1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity

(2016) Daqian Yang et al.   Scientific Reports

Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation

(2015) Jeong Su Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ROS-dependent signal transduction

(2015) Colleen R Reczek et al.   CURRENT OPINION IN CELL BIOLOGY

Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy

(2015) Xinhua Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effects of luteolin against acetaminophen-induced acute liver failure in mouse

(2015) Minghui Tai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gynura procumbens Reverses Acute and Chronic Ethanol-Induced Liver Steatosis through MAPK/SREBP-1c-Dependent and -Independent Pathways

(2015) Xiao-Jun Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Protective Effect of Panax notoginseng Saponins on Acute Ethanol-Induced Liver Injury Is Associated with Ameliorating Hepatic Lipid Accumulation and Reducing Ethanol-Mediated Oxidative Stress

(2015) Ren-Bo Ding et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy

(2014) Lili Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Luteolin Alleviates Alcoholic Liver Disease Induced by Chronic and Binge Ethanol Feeding in Mice

(2014) Gaigai Liu et al.   JOURNAL OF NUTRITION

Antioxidant and Hepatoprotective Activity of Veronica ciliata Fisch. Extracts Against Carbon Tetrachloride-Induced Liver Injury in Mice

(2014) Li Yin et al.   MOLECULES

Role ofAdhatoda vasica(L.) Nees leaf extract in the prevention of aflatoxin-induced toxicity in Wistar rats

(2013) Rajendran Brinda et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

The protective effect of eicosapentaenoic acid-enriched phospholipids from sea cucumber Cucumaria frondosa on oxidative stress in PC12 cells and SAMP8 mice

(2013) Feng-Juan Wu et al.   NEUROCHEMISTRY INTERNATIONAL

NRF2 Protection against Liver Injury Produced by Various Hepatotoxicants

(2013) Jie Liu et al.   Oxidative Medicine and Cellular Longevity

Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage

(2012) Soo Han Bae et al.   Cell Metabolism

Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation

(2012) Kai Connie Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Protective Effects of Luteolin against Apoptotic Liver Damage Induced byd-Galactosamine/Lipopolysaccharide in Mice

(2011) Woo-Cheol Lee et al.   JOURNAL OF NATURAL PRODUCTS

Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice

(2010) Wen–Xing Ding et al.   GASTROENTEROLOGY

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

(2010) Ian M. Copple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Induction of Sulfiredoxin via an Nrf2-Dependent Pathway and Hyperoxidation of Peroxiredoxin III in the Lungs of Mice Exposed to Hyperoxia

(2008) Soo Han Bae et al.   ANTIOXIDANTS & REDOX SIGNALING