Spontaneous lipid binding to the nicotinic acetylcholine receptor in a native membrane

Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine-only bilayer

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Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape

(2020) J. H. Lorent et al.   Nature Chemical Biology

Understanding the Link between Lipid Diversity and the Biophysical Properties of the Neuronal Plasma Membrane

(2020) Katie A. Wilson et al.   BIOCHEMISTRY

Capturing biologically complex tissue-specific membranes at different levels of compositional complexity

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Structural basis for the modulation of pentameric ligand-gated ion channel function by lipids

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Shared structural mechanisms of general anaesthetics and benzodiazepines

(2020) Jeong Joo Kim et al.   NATURE

Boundary lipids of the nicotinic acetylcholine receptor: Spontaneous partitioning via coarse-grained molecular dynamics simulation

(2019) Liam Sharp et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Computational Modeling of Realistic Cell Membranes

(2019) Siewert J. Marrink et al.   CHEMICAL REVIEWS

Untangling Direct and Domain-Mediated Interactions Between Nicotinic Acetylcholine Receptors in DHA-Rich Membranes

(2019) Kristen Woods et al.   JOURNAL OF MEMBRANE BIOLOGY

Insights into Membrane Protein–Lipid Interactions from Free Energy Calculations

(2019) Robin A. Corey et al.   Journal of Chemical Theory and Computation

Pitfalls of the Martini Model

(2019) Riccardo Alessandri et al.   Journal of Chemical Theory and Computation

Altered polyunsaturated fatty acid levels in relation to proinflammatory cytokines, fatty acid desaturase genotype, and diet in bipolar disorder

(2019) Norie Koga et al.   Translational Psychiatry

A lipid site shapes the agonist response of a pentameric ligand-gated ion channel

(2019) Camille M. Hénault et al.   Nature Chemical Biology

L-3,3’,5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors

(2019) Steven X. Moffett et al.   PLoS One

Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel

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Capturing Phase Behavior of Ternary Lipid Mixtures with a Refined Martini Coarse-Grained Force Field

(2018) Timothy S Carpenter et al.   Journal of Chemical Theory and Computation

A Streamlined, General Approach for Computing Ligand Binding Free Energies and Its Application to GPCR-Bound Cholesterol

(2018) Reza Salari et al.   Journal of Chemical Theory and Computation

Conformational transitions of the serotonin 5-HT3 receptor

(2018) Lucie Polovinkin et al.   NATURE

Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel

(2018) Melissa M. Budelier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway

(2017) Hiral Patel et al.   Journal of Neuroinflammation

Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites

(2017) Duncan Laverty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lipids in psychiatric disorders and preventive medicine

(2017) Miriam Schneider et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites

(2017) Duncan Laverty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel

(2017) Sandip Basak et al.   eLife

Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes

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Molecular dynamics simulations of membrane proteins and their interactions: from nanoscale to mesoscale

(2016) Matthieu Chavent et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Identification and characterization of heptapeptide modulators of the glycine receptor

(2016) Garrett L. Cornelison et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR

(2016) Nuriya Mukhtasimova et al.   JOURNAL OF GENERAL PHYSIOLOGY

Common Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion Channel

(2016) Thomas T. Joseph et al.   PLoS One

Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamer

(2016) Nikolaos Kouvatsos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine

(2016) Mieke Nys et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncovering the lipidic basis for the preparation of functional nicotinic acetylcholine receptor detergent complexes for structural studies

(2016) Orestes Quesada et al.   Scientific Reports

Microtransplantation of Cellular Membranes From Squid Stellate Ganglion Reveals Ionotropic GABA Receptors

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Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

(2015) Javier Egea et al.   BIOCHEMICAL PHARMACOLOGY

High-order power series expansion of the elastic interaction between conical membrane inclusions

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Computational Lipidomics with insane: A Versatile Tool for Generating Custom Membranes for Molecular Simulations

(2015) Tsjerk A. Wassenaar et al.   Journal of Chemical Theory and Computation

The role of the M4 lipid-sensor in the folding, trafficking, and allosteric modulation of nicotinic acetylcholine receptors

(2015) Camille M. Hénault et al.   NEUROPHARMACOLOGY

Fatty acid composition of the postmortem prefrontal cortex of patients with schizophrenia, bipolar disorder, and major depressive disorder

(2015) Kei Hamazaki et al.   PSYCHIATRY RESEARCH

Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC

(2015) Qiang Chen et al.   Scientific Reports

A Predicted Binding Site for Cholesterol on the GABAA Receptor

(2014) Jérôme Hénin et al.   BIOPHYSICAL JOURNAL

Lipid Organization of the Plasma Membrane

(2014) Helgi I. Ingólfsson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipid Integration in Neurodegeneration: An Overview of Alzheimer’s Disease

(2014) Rajesh Singh Yadav et al.   MOLECULAR NEUROBIOLOGY

Structure and superorganization of acetylcholine receptor-rapsyn complexes

(2013) B. Zuber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using neurolipidomics to identify phospholipid mediators of synaptic (dys)function in Alzheimer's Disease

(2013) Steffany A. L. Bennett et al.   Frontiers in Physiology

Improved Parameters for the Martini Coarse-Grained Protein Force Field

(2012) Djurre H. de Jong et al.   Journal of Chemical Theory and Computation

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors

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Transmembrane helices can induce domain formation in crowded model membranes

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Linking lipids to Alzheimer's disease: cholesterol and beyond

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Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor

(2011) Carlos J. Baier et al.   Scientific Reports

Neuronal Nicotinic Acetylcholine Receptors - Targets for the Development of Drugs to Treat Cognitive Impairment Associated with Schizophrenia and Alzheimers Disease

(2010) Simon Haydar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Lipid map of the mammalian cell

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Precise and global identification of phospholipid molecular species by an Orbitrap mass spectrometer and automated search engine Lipid Search

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5-HT3 receptors: Role in disease and target of drugs

(2010) Jutta Walstab et al.   PHARMACOLOGY & THERAPEUTICS

Anionic Lipids Allosterically Modulate Multiple Nicotinic Acetylcholine Receptor Conformational Equilibria

(2009) Corrie J. B. daCosta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combining an Elastic Network With a Coarse-Grained Molecular Force Field: Structure, Dynamics, and Intermolecular Recognition

(2009) Xavier Periole et al.   Journal of Chemical Theory and Computation

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Nicotinic acetylcholine receptor is internalized via a Rac-dependent, dynamin-independent endocytic pathway

(2008) Sudha Kumari et al.   JOURNAL OF CELL BIOLOGY

Embedded cholesterol in the nicotinic acetylcholine receptor

(2008) G. Brannigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder

(2008) Robert K. McNamara et al.   PSYCHIATRY RESEARCH

Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease

(2007) Marina et al.   Frontiers in Bioscience-Landmark