Metabolic dysfunction and immunometabolism in COVID-19 pathophysiology and therapeutics

Targeting immunometabolism as an anti-inflammatory strategy

(2020) Eva M. Pålsson-McDermott et al.   CELL RESEARCH

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Obesity in Patients Younger Than 60 Years Is a Risk Factor for COVID-19 Hospital Admission

(2020) Jennifer Lighter et al.   CLINICAL INFECTIOUS DISEASES

Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes

(2020) Massimiliano Bonafè et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Glycolysis – a key player in the inflammatory response

(2020) Gonzalo Soto‐Heredero et al.   FEBS Journal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Clinical Characteristics of Covid-19 in New York City

(2020) Parag Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhanced glycolysis and HIF-1α activation in adipose tissue macrophages sustains local and systemic interleukin-1β production in obesity

(2020) Monika Sharma et al.   Scientific Reports

Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York

(2020) Leonidas Palaiodimos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease

(2020) Divya P. Kumar et al.   Scientific Reports

The race to make COVID antibody therapies cheaper and more potent

(2020) Heidi Ledford   NATURE

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

(2019) Yong Pan et al.   JOURNAL OF CLINICAL INVESTIGATION

The Metabolic Signature of Macrophage Responses

(2019) Antonella Viola et al.   Frontiers in Immunology

Cardiovascular and Metabolic Heterogeneity of Obesity

(2018) Ian J. Neeland et al.   CIRCULATION

Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses

(2018) Lily Boutens et al.   DIABETOLOGIA

Insulin resistance causes inflammation in adipose tissue

(2018) Mitsugu Shimobayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity

(2018) Mengle Shao et al.   Nature Communications

Ventilator Dependence Risk Score for the Prediction of Prolonged Mechanical Ventilation in Patients Who Survive Sepsis/Septic Shock with Respiratory Failure

(2018) Ya-Chun Chang et al.   Scientific Reports

Properties and functions of adipose tissue macrophages in obesity

(2018) Lucia Russo et al.   IMMUNOLOGY

Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality

(2018) Lynn M. Frydrych et al.   JOURNAL OF LEUKOCYTE BIOLOGY

GM-CSF Administration Improves Defects in Innate Immunity and Sepsis Survival in Obese Diabetic Mice

(2018) Lynn M. Frydrych et al.   JOURNAL OF IMMUNOLOGY

Obesity and Type 2 Diabetes mellitus induce lipopolysaccharide tolerance in rat neutrophils

(2018) Wilson Mitsuo Tatagiba Kuwabara et al.   Scientific Reports

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

(2017) Gökhan S. Hotamisligil   IMMUNITY

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity

(2016) Byung-Cheol Lee et al.   Cell Metabolism

Obesity-associated Inflammation Induces microRNA-155 Expression in Adipocytes and Adipose Tissue: Outcome on Adipocyte Function

(2016) Esma Karkeni et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance

(2016) Kae Won Cho et al.   JOURNAL OF IMMUNOLOGY

Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients

(2016) Hannah Mathew et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Impact of Obesity and Metabolic Syndrome on Immunity

(2016) Catherine J Andersen et al.   Advances in Nutrition

The Cellular and Molecular Basis of Translational Immunometabolism

(2015) Giuseppe Danilo Norata et al.   IMMUNITY

PPARs: Protectors or Opponents of Myocardial Function?

(2015) Christine J. Pol et al.   PPAR Research

Obesity Is a Positive Modulator of IL-6R and IL-6 Expression in the Subcutaneous Adipose Tissue: Significance for Metabolic Inflammation

(2015) Sardar Sindhu et al.   PLoS One

MicroRNAs in lupus

(2014) Hong Zan et al.   AUTOIMMUNITY

The role of NF-кB in SAA-induced peroxisome proliferator-activated receptor γ activation

(2013) Hongzhe Li et al.   ATHEROSCLEROSIS

Pioglitazone reduces inflammation through inhibition of NF-κB in polymicrobial sepsis

(2013) Jennifer Kaplan et al.   Innate Immunity

miR-223: infection, inflammation and cancer

(2013) M. Haneklaus et al.   JOURNAL OF INTERNAL MEDICINE

MyD88 as a target of microRNA-203 in regulation of lipopolysaccharide or Bacille Calmette-Guerin induced inflammatory response of macrophage RAW264.7 cells

(2013) Jun Wei et al.   MOLECULAR IMMUNOLOGY

Natural Killer Cell Function, an Important Target for Infection and Tumor Protection, Is Impaired in Type 2 Diabetes

(2013) Jeannig Berrou et al.   PLoS One

Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b

(2013) G. Curtale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of MicroRNAs miR-200b and miR-200c in TLR4 signaling and NF-κB activation

(2012) Erik B Wendlandt et al.   Innate Immunity

Decreased interferon-α and interferon-β production in obesity and expression of suppressor of cytokine signaling

(2012) Eli Teran-Cabanillas et al.   NUTRITION

Adipose Tissue Dysregulation in Patients with Metabolic Syndrome

(2011) Andrew A. Bremer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

(2011) C. N. Lumeng et al.   JOURNAL OF IMMUNOLOGY

MicroRNAs in inflammation and immune responses

(2011) J Contreras et al.   LEUKEMIA

MicroRNAs 103 and 107 regulate insulin sensitivity

(2011) Mirko Trajkovski et al.   NATURE

Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

(2011) R. J. A. Frost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs in NF- B signaling

(2011) X. Ma et al.   Journal of Molecular Cell Biology

MicroRNAs Distinguish Translational from Transcriptional Silencing during Endotoxin Tolerance

(2010) Mohamed El Gazzar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism