PPARs: Protectors or Opponents of Myocardial Function?

Activation of PPARδ signaling improves skeletal muscle oxidative metabolism and endurance function in an animal model of ischemic left ventricular dysfunction

(2015) Cynthia Zizola et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiomyocyte lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs

(2015) Taha Haffar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes

(2015) James D. Lewis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination

(2015) Jessica E. Rodríguez et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

KLF15 and PPARαCooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation

(2015) Domenick A. Prosdocimo et al.   PPAR Research

Observational Study of Effects of Saroglitazar on Glycaemic and Lipid Parameters on Indian Patients with Type 2 Diabetes

(2015) Sanjay Chatterjee et al.   Scientific Reports

Dietary Fat Supply to Failing Hearts Determines Dynamic Lipid Signaling for Nuclear Receptor Activation and Oxidation of Stored Triglyceride

(2014) Ryan Lahey et al.   CIRCULATION

The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma–associated adverse cardiac effects

(2014) Rémy Hanf et al.   Diabetes & Vascular Disease Research

Effect of Aleglitazar on Cardiovascular Outcomes After Acute Coronary Syndrome in Patients With Type 2 Diabetes Mellitus

(2014) A. Michael Lincoff et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibition of HDAC3 promotes ligand-independent PPARγ activation by protein acetylation

(2014) Xiaoting Jiang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Regulation of peroxisome proliferator-activated receptor β/δ expression and activity levels by toll-like receptor agonists and MAP kinase inhibitors in rat astrocytes

(2014) Dmitry V. Chistyakov et al.   JOURNAL OF NEUROCHEMISTRY

Cardiomyocyte specific peroxisome proliferator-activated receptor-α overexpression leads to irreversible damage in ischemic murine heart

(2014) Georg D. Duerr et al.   LIFE SCIENCES

TNF-Like Weak Inducer of Apoptosis Aggravates Left Ventricular Dysfunction after Myocardial Infarction in Mice

(2014) Kai-Uwe Jarr et al.   MEDIATORS OF INFLAMMATION

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

(2014) Alexander S. Banks et al.   NATURE

HMGB1 Is Involved in the Protective Effect of the PPARαAgonist Fenofibrate against Cardiac Hypertrophy

(2014) Zhankui Jia et al.   PPAR Research

Results of a reevaluation of cardiovascular outcomes in the RECORD trial

(2013) Kenneth W. Mahaffey et al.   AMERICAN HEART JOURNAL

Tempol prevents cardiac oxidative damage and left ventricular dysfunction in the PPAR-α KO mouse

(2013) Aziz Guellich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

l-Carnitine protects against arterial hypertension-related cardiac fibrosis through modulation of PPAR-γ expression

(2013) Sonia Zambrano et al.   BIOCHEMICAL PHARMACOLOGY

Delayed cardioprotective effects of WY-14643 are associated with inhibition of MMP-2 and modulation of Bcl-2 family proteins through PPAR-α activation in rat hearts subjected to global ischaemia–reperfusion

(2013) Eleftheria Barlaka et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation

(2013) J-H Kim et al.   CELL DEATH AND DIFFERENTIATION

Peroxisome Proliferator–Activated Receptor-γ Activation Prevents Sepsis-Related Cardiac Dysfunction and Mortality In Mice

(2013) Konstantinos Drosatos et al.   Circulation-Heart Failure

Fenofibrate ameliorates cardiac hypertrophy by activation of peroxisome proliferator-activated receptor-α partly via preventing p65-NFκB binding to NFATc4

(2013) Jian Zou et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

HIV-1 Vpr Enhances PPARβ/δ-Mediated Transcription, Increases PDK4 Expression, and Reduces PDC Activity

(2013) Shashi Shrivastav et al.   MOLECULAR ENDOCRINOLOGY

Ligand Binding Reduces SUMOylation of the Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation Function 1 (AF1) Domain

(2013) Rolf Diezko et al.   PLoS One

An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis

(2013) R. J. Langley et al.   Science Translational Medicine

PPAR-alpha activation as a preconditioning-like intervention in rats in vivo confers myocardial protection against acute ischaemia–reperfusion injury: involvement of PI3K–Akt

(2012) Táňa Ravingerová et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Infarct-remodelled hearts with limited oxidative capacity boost fatty acid oxidation after conditioning against ischaemia/reperfusion injury

(2012) Phing-How Lou et al.   CARDIOVASCULAR RESEARCH

Suppression of ERR targets by a PPARα/Sirt1 complex in the failing heart

(2012) Shin-ichi Oka et al.   CELL CYCLE

Impact of Sex on Cardiovascular Outcome in Patients at High Cardiovascular Risk

(2012) Kai Kappert et al.   CIRCULATION

Structural basis for telmisartan-mediated partial activation of PPAR gamma

(2012) Yasushi Amano et al.   HYPERTENSION RESEARCH

The Role of PPARα in Metformin-Induced Attenuation of Mitochondrial Dysfunction in Acute Cardiac Ischemia/Reperfusion in Rats

(2012) Giselle Barreto-Torres et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat

(2012) Elin Strand et al.   Lipids in Health and Disease

A ROSy future for metabolic regulation of HSC division

(2012) Hal E Broxmeyer et al.   NATURE MEDICINE

Atorvastatin May Delay Cardiac Aging by Upregulating Peroxisome Proliferator-Activated Receptors in Rats

(2012) Lei Han et al.   PHARMACOLOGY

Effects of PPARs Agonists on Cardiac Metabolism in Littermate and Cardiomyocyte-Specific PPAR-γ –Knockout (CM-PGKO) Mice

(2012) Michelangela Barbieri et al.   PLoS One

PPARs: Fatty acid sensors controlling metabolism

(2012) Lars la Cour Poulsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation

(2011) Kristine M. Wadosky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-γ-independent manner

(2011) Yochai Birnbaum et al.   BASIC RESEARCH IN CARDIOLOGY

O-GlcNAc modification of PPARγ reduces its transcriptional activity

(2011) Suena Ji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

(2011) Tamas Varga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway

(2011) Shinichi Oka et al.   Cell Metabolism

Toll-Like Receptor-Mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-Activated Receptor γ Coactivator-1 Signaling

(2011) Joel Schilling et al.   Circulation-Heart Failure

Peroxisome Proliferator-Activated Receptor β/δ Activation in Adult Hearts Facilitates Mitochondrial Function and Cardiac Performance Under Pressure-Overload Condition

(2011) Jian Liu et al.   HYPERTENSION

Inhibition of c-Jun-N-terminal Kinase Increases Cardiac Peroxisome Proliferator-activated Receptor α Expression and Fatty Acid Oxidation and Prevents Lipopolysaccharide-induced Heart Dysfunction

(2011) Konstantinos Drosatos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-activated Receptor (PPAR) Gene Profiling Uncovers Insulin-like Growth Factor-1 as a PPARα Target Gene in Cardioprotection

(2011) Hamid el Azzouzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactivation of Peroxisome Proliferator-activated Receptor Alpha in Spontaneously Hypertensive Rat: Age-associated Paradoxical Effect on the Heart

(2011) Sreeja Purushothaman et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Transforming growth factor-β inhibits myocardial PPARγ expression in pressure overload-induced cardiac fibrosis and remodeling in mice

(2011) Kaizheng Gong et al.   JOURNAL OF HYPERTENSION

Telmisartan, a unique ARB, improves left ventricular remodeling of infarcted heart by activating PPAR gamma

(2011) Yasuhiro Maejima et al.   LABORATORY INVESTIGATION

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

VLDL Hydrolysis by Hepatic Lipase Regulates PPARδ Transcriptional Responses

(2011) Jonathan D. Brown et al.   PLoS One

Cardiomyocyte-Restricted Deletion of PPARβ/δin PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation

(2011) Jian Liu et al.   PPAR Research

Estrogen receptor mediates the effects of pseudoprotodiocsin on adipogenesis in 3T3-L1 cells

(2010) Jing Xiao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Protective Role of Peroxisome Proliferator–activated Receptor-β/δ in Septic Shock

(2010) Amar Kapoor et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Docosahexaenoic acid increases cellular adiponectin mRNA and secreted adiponectin protein, as well as PPARγ mRNA, in 3T3-L1 adipocytes

(2010) Richard T. Oster et al.   Applied Physiology Nutrition and Metabolism

Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor α (PPARα)

(2010) Beena Vallanat et al.   BMC GENOMICS

Controlling cardiomyocyte length: the role of renin and PPAR-γ

(2010) Söhnke Hinrichs et al.   CARDIOVASCULAR RESEARCH

Thiazolidinedione Drugs and Cardiovascular Risks

(2010) Sanjay Kaul et al.   CIRCULATION

Preferential Oxidation of Triacylglyceride-Derived Fatty Acids in Heart Is Augmented by the Nuclear Receptor PPARα

(2010) Natasha H. Banke et al.   CIRCULATION RESEARCH

Peroxisome Proliferator-Activated Receptor δ Is an Essential Transcriptional Regulator for Mitochondrial Protection and Biogenesis in Adult Heart

(2010) Peiyong Wang et al.   CIRCULATION RESEARCH

O -GlcNAc Signaling in the Cardiovascular System

(2010) Gladys A. Ngoh et al.   CIRCULATION RESEARCH

Advanced glycation end products downregulates peroxisome proliferator-activated receptor γ expression in cultured rabbit chondrocyte through MAPK pathway

(2010) Qingshan Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Risk of Acute Myocardial Infarction, Stroke, Heart Failure, and Death in Elderly Medicare Patients Treated With Rosiglitazone or Pioglitazone

(2010) David J. Graham et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ultraviolet A Regulates Adipogenic Differentiation of Human Adipose Tissue-derived Mesenchymal Stem Cells via Up-regulation of Kruppel-like Factor 2

(2010) Jongsung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-27b Contributes to Lipopolysaccharide-mediated Peroxisome Proliferator-activated Receptor γ (PPARγ) mRNA Destabilization

(2010) Carla Jennewein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β,β-Carotene Decreases Peroxisome Proliferator Receptor γ Activity and Reduces Lipid Storage Capacity of Adipocytes in a β,β-Carotene Oxygenase 1-dependent Manner

(2010) Glenn P. Lobo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin accessibility and transcription factor binding at the PPARγ2 promoter during adipogenesis is protein kinase A-dependent

(2010) Hengyi Xiao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation

(2010) Ni-Huiping Son et al.   JOURNAL OF CLINICAL INVESTIGATION

Repression of Peroxisome Proliferator-Activated Receptor   by Mucosal Ribotoxic Insult-Activated CCAAT/Enhancer-Binding Protein Homologous Protein

(2010) S.-H. Park et al.   JOURNAL OF IMMUNOLOGY

Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis

(2010) Min Jun et al.   LANCET

Leptin inhibits PPARγ gene expression in hepatic stellate cells in the mouse model of liver damage

(2010) Yajun Zhou et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Transcriptional control of preadipocyte determination by Zfp423

(2010) Rana K. Gupta et al.   NATURE

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

ACTIVATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-β/δ ATTENUATES MYOCARDIAL ISCHEMIA/REPERFUSION INJURY IN THE RAT

(2010) Amar Kapoor et al.   SHOCK

Detection of Left Ventricular Hypertrophy in Rats Administered a Peroxisome Proliferator–Activated Receptor α/γ Dual Agonist Using Natriuretic Peptides and Imaging

(2010) Steven K. Engle et al.   TOXICOLOGICAL SCIENCES

The peroxisome proliferator-activated receptor-α (PPAR-α) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats

(2009) Wolfgang Linz et al.   ACTA PHARMACOLOGICA SINICA

Transcription Factors Krüppel-Like Factor 6 and Peroxisome Proliferator-Activated Receptor-γ Mediate High Glucose-Induced Thioredoxin-Interacting Protein

(2009) Weier Qi et al.   AMERICAN JOURNAL OF PATHOLOGY

Antidiabetic drug pioglitazone protects the heart via activation of PPAR-γ receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction

(2009) Shinji Yasuda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rosiglitazone Ameliorates Endotoxin-Induced Organ Damage in Conscious Rats

(2009) W.-T. Wu et al.   Biological Research for Nursing

Cardiac peroxisome proliferator-activated receptor-α activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss

(2009) Anne D. Hafstad et al.   CARDIOVASCULAR RESEARCH

Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR γ through JNK-dependent upregulation of iNOS

(2009) Jongsung Lee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Adiponectin

(2009) Ling Tao et al.   CIRCULATION RESEARCH

Adiponectin Expression Is Induced by Vitamin E via a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism

(2009) Jean-François Landrier et al.   ENDOCRINOLOGY

Adenosine monophosphate-activated protein kinase inhibits cardiac hypertrophy through reactivating peroxisome proliferator-activated receptor-α signaling pathway

(2009) Rong-Sen Meng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SUMOylation of Human Peroxisome Proliferator-activated Receptor α Inhibits Its Trans-activity through the Recruitment of the Nuclear Corepressor NCoR

(2009) Benoit Pourcet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt

(2009) Mayuko F Kato et al.   JOURNAL OF HYPERTENSION

Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial

(2009) Philip D Home et al.   LANCET

Molecular mechanism underlying the suppression of lipid oxidation during endotoxemia

(2009) Urmila Maitra et al.   MOLECULAR IMMUNOLOGY

Metabolomics of the interaction between PPAR-α and age in the PPAR-α-null mouse

(2009) Helen J Atherton et al.   Molecular Systems Biology

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Glucose represses PPARαgene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic β-cell

(2009) Erik JOLY et al.   Journal of Diabetes

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Cardiac hypertrophy is enhanced in PPAR -/- mice in response to chronic pressure overload

(2008) P. J.H. Smeets et al.   CARDIOVASCULAR RESEARCH

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Differential Roles of Cardiomyocyte and Macrophage Peroxisome Proliferator-Activated Receptor   in Cardiac Fibrosis

(2008) E. Caglayan et al.   DIABETES

Different effect of acute treatment with rosiglitazone on rat myocardial ischemia/reperfusion injury by administration method

(2008) Masahiro Abe et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

(2008) Rusty L. Montgomery et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

(2008) Xiaoyong Yang et al.   NATURE

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE

Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events

(2008) Salim Yusuf et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptomic analysis of PPARα-dependent alterations during cardiac hypertrophy

(2008) Pascal J. H. Smeets et al.   PHYSIOLOGICAL GENOMICS

Effect of GCP-02, a PPARalpha/gamma dual activator, on glucose and lipid metabolism in insulin-resistant mice

(2007) Zhen-ji Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY