Omics Data and Their Integrative Analysis to Support Stratified Medicine in Neurodegenerative Diseases

Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets

(2021) Ryan A. Neff et al.   Science Advances

The Mutation Matters: CSF Profiles of GCase , Sphingolipids, α‐Synuclein in PD GBA

(2021) Stefanie Lerche et al.   MOVEMENT DISORDERS

Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets

(2021) Demis A. Kia et al.   JAMA Neurology

An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer’s disease

(2021) Christopher Clark et al.   Alzheimers Research & Therapy

Emerging genetic complexity and rare genetic variants in neurodegenerative brain diseases

(2021) Federica Perrone et al.   Genome Medicine

High Throughput Multi-Omics Approaches for Clinical Trial Evaluation and Drug Discovery

(2021) Jessica M. Zielinski et al.   Frontiers in Immunology

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease

(2020) Tosha Williams et al.   Molecular Neurodegeneration

Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration

(2020) Elisabeth H. Thijssen et al.   NATURE MEDICINE

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

(2020) Bing Bai et al.   NEURON

Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson’s disease

(2020) Phillippa J Carling et al.   PROGRESS IN NEUROBIOLOGY

Novel Alzheimer’s disease subtypes identified using a data and knowledge driven strategy

(2020) Alexis Mitelpunkt et al.   Scientific Reports

Splicing Players Are Differently Expressed in Sporadic Amyotrophic Lateral Sclerosis Molecular Clusters and Brain Regions

(2020) Valentina La Cognata et al.   Cells

Summary-Based Methylome-Wide Association Analyses Suggest Potential Genetically Driven Epigenetic Heterogeneity of Alzheimer’s Disease

(2020) Alireza Nazarian et al.   Journal of Clinical Medicine

Exploring Alzheimer’s Disease Molecular Variability via Calculation of Personalized Transcriptional Signatures

(2020) Hila Dagan et al.   Biomolecules

GBA ‐Related Parkinson's Disease: Dissection of Genotype–Phenotype Correlates in a Large Italian Cohort

(2020) Simona Petrucci et al.   MOVEMENT DISORDERS

Transcriptomic stratification of late-onset Alzheimer's cases reveals novel genetic modifiers of disease pathology

(2020) Nikhil Milind et al.   PLoS Genetics

Genetics of Parkinson's disease

(2020) Ajith Cherian et al.   ACTA NEUROLOGICA BELGICA

Omics-based exploration and functional validation of neurotrophic factors and histamine as therapeutic targets in ALS

(2020) Cinzia Volonté et al.   AGEING RESEARCH REVIEWS

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

(2020) Raffaella Nativio et al.   NATURE GENETICS

Rethinking monogenic neurological diseases

(2020) Wan-Jin Chen et al.   BMJ-British Medical Journal

Precision medicine in Parkinson’s disease patients with LRRK2 and GBA risk variants – Let’s get even more personal

(2020) Christian U. von Linstow et al.   Translational Neurodegeneration

Common Factors in Neurodegeneration: A Meta-Study Revealing Shared Patterns on a Multi-Omics Scale

(2020) Nicolas Ruffini et al.   Cells

Prognosis and Neuropathologic Correlation of Clinical Subtypes of Parkinson Disease

(2019) Eduardo De Pablo-Fernández et al.   JAMA Neurology

Precision medicine: discovering clinically relevant and mechanistically anchored disease subgroups at scale

(2019) Antony Rosen et al.   JOURNAL OF CLINICAL INVESTIGATION

Prediagnostic plasma metabolomics and the risk of amyotrophic lateral sclerosis

(2019) Kjetil Bjornevik et al.   NEUROLOGY

Histaminergic transmission slows progression of amyotrophic lateral sclerosis

(2019) Savina Apolloni et al.   Journal of Cachexia Sarcopenia and Muscle

A Systematic Review of Suggested Molecular Strata, Biomarkers and Their Tissue Sources in ALS

(2019) Udaya Geetha Vijayakumar et al.   Frontiers in Neurology

Contested futures: envisioning “Personalized,” “Stratified,” and “Precision” medicine

(2019) Sonja Erikainen et al.   NEW GENETICS AND SOCIETY

Integrative multi-omic analysis identifies new drivers and pathways in molecularly distinct subtypes of ALS

(2019) Giovanna Morello et al.   Scientific Reports

Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

(2019) Yiyi Ma et al.   JAMA Neurology

The Need for Multi-Omics Biomarker Signatures in Precision Medicine

(2019) Michael Olivier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular pathology of neurodegenerative diseases: principles and practice

(2019) Gabor G Kovacs   JOURNAL OF CLINICAL PATHOLOGY

Multi-omics signature of brain amyloid deposition in asymptomatic individuals at-risk for Alzheimer's disease: The INSIGHT-preAD study

(2019) Laura Xicota et al.   EBioMedicine

Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients

(2019) Olli Jääskeläinen et al.   JOURNAL OF ALZHEIMERS DISEASE

Biomarker-guided clustering of Alzheimer's disease clinical syndromes

(2019) Nicola Toschi et al.   NEUROBIOLOGY OF AGING

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

(2019) Oliver H. Tam et al.   Cell Reports

A multiomics approach to heterogeneity in Alzheimer’s disease: focused review and roadmap

(2019) AmanPreet Badhwar et al.   BRAIN

Two Decades-Long Journey from Riluzole to Edaravone: Revisiting the Clinical Pharmacokinetics of the Only Two Amyotrophic Lateral Sclerosis Therapeutics

(2018) Ranjeet Prasad Dash et al.   CLINICAL PHARMACOKINETICS

The clinical heterogeneity of Parkinson's disease and its therapeutic implications

(2018) J C Greenland et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Validation of AclarusDx™, a Blood-Based Transcriptomic Signature for the Diagnosis of Alzheimer's Disease

(2018) Pascale Fehlbaum-Beurdeley et al.   JOURNAL OF ALZHEIMERS DISEASE

Developing and validating Parkinson’s disease subtypes and their motor and cognitive progression

(2018) Michael Lawton et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs

(2018) Manoj Kumar Jaiswal   MEDICINAL RESEARCH REVIEWS

A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research

(2018) Philip L. De Jager et al.   Scientific Data

The heterogeneity within Alzheimer's disease

(2018) Daniel Ferreira et al.   Aging-US

Genetic data and cognitively defined late-onset Alzheimer’s disease subgroups

(2018) Shubhabrata Mukherjee et al.   MOLECULAR PSYCHIATRY

Heterogeneity of Alzheimer’s disease: consequence for drug trials?

(2018) Gayatri Devi et al.   Alzheimers Research & Therapy

The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis

(2018) Geraldine Hipp et al.   Frontiers in Aging Neuroscience

Metabolomics Biomarkers: A Strategy Toward Therapeutics Improvement in ALS

(2018) Débora Lanznaster et al.   Frontiers in Neurology

Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis

(2017) Hideyuki Sawada   EXPERT OPINION ON PHARMACOTHERAPY

Genetic Stratification to Identify Risk Groups for Alzheimer’s Disease

(2017) Riccardo E. Marioni et al.   JOURNAL OF ALZHEIMERS DISEASE

Classification of advanced stages of Parkinson’s disease: translation into stratified treatments

(2017) Rejko Krüger et al.   JOURNAL OF NEURAL TRANSMISSION

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases

(2017) Michael G. Erkkinen et al.   Cold Spring Harbor Perspectives in Biology

Parkinson's Disease Subtypes Identified from Cluster Analysis of Motor and Non-motor Symptoms

(2017) Jesse Mu et al.   Frontiers in Aging Neuroscience

ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?

(2017) Dmitry Petrov et al.   Frontiers in Aging Neuroscience

Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology

(2017) Jose A. Santiago et al.   Frontiers in Aging Neuroscience

Histamine Regulates the Inflammatory Profile of SOD1-G93A Microglia and the Histaminergic System Is Dysregulated in Amyotrophic Lateral Sclerosis

(2017) Savina Apolloni et al.   Frontiers in Immunology

Molecular Taxonomy of Sporadic Amyotrophic Lateral Sclerosis Using Disease-Associated Genes

(2017) Giovanna Morello et al.   Frontiers in Neurology

Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson’s disease: a pharmacogenetic study

(2016) Mario Masellis et al.   BRAIN

Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences

(2016) Claudia Manzoni et al.   BRIEFINGS IN BIOINFORMATICS

Copy number variability in Parkinson’s disease: assembling the puzzle through a systems biology approach

(2016) Valentina La Cognata et al.   HUMAN GENETICS

From Common to Rare Variants: The Genetic Component of Alzheimer Disease

(2016) Gaël Nicolas et al.   HUMAN HEREDITY

The Clinical Use of Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease Diagnosis: The Italian Selfie

(2016) Giulia M. Sancesario et al.   JOURNAL OF ALZHEIMERS DISEASE

Alpha-synuclein gene variants may predict neurostimulation outcome

(2016) Daniel Weiss et al.   MOVEMENT DISORDERS

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Metabolic profiling distinguishes three subtypes of Alzheimer's disease

(2015) Dale E. Bredesen   Aging-US

Selection of Potential Pharmacological Targets in ALS Based on Whole- Genome Expression Profiling

(2015) Giovanna Morello et al.   CURRENT MEDICINAL CHEMISTRY

Transcriptional analysis reveals distinct subtypes in amyotrophic lateral sclerosis: implications for personalized therapy

(2015) Giovanna Morello et al.   Future Medicinal Chemistry

Molecular classification of amyotrophic lateral sclerosis by unsupervised clustering of gene expression in motor cortex

(2015) Eleonora Aronica et al.   NEUROBIOLOGY OF DISEASE

Usefulness of Genetic Testing in PD and PD Trials: A Balanced Review

(2015) Thomas Gasser   Journal of Parkinsons Disease

Plasma Metabolite Profiles of Alzheimer’s Disease and Mild Cognitive Impairment

(2014) Gang Wang et al.   JOURNAL OF PROTEOME RESEARCH

Overview and Findings from the Religious Orders Study

(2013) David A. Bennett et al.   Current Alzheimer Research

Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature

(2013) A. Chiò et al.   NEUROEPIDEMIOLOGY

Parkinson's disease subtypes: lost in translation?

(2012) C. Marras et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Metabolite Profiling of Alzheimer's Disease Cerebrospinal Fluid

(2012) Christian Czech et al.   PLoS One

ALS patients with mutations in the SOD1 gene have an unique metabolomic profile in the cerebrospinal fluid compared with ALS patients without mutations

(2011) Anna Wuolikainen et al.   MOLECULAR GENETICS AND METABOLISM

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY