Structural and Functional Remodeling of Mitochondria in Cardiac Diseases

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology

(2020) Robert G. Abrisch et al.   JOURNAL OF CELL BIOLOGY

Sarco/Endoplasmic Reticulum Calcium ATPase Inhibitors: Beyond Anticancer Perspective

(2020) Lucie Peterková et al.   JOURNAL OF MEDICINAL CHEMISTRY

Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane

(2020) Yifan Ge et al.   eLife

Valosin-Containing Protein, a Calcium-Associated ATPase Protein, in Endoplasmic Reticulum and Mitochondrial Function and Its Implications for Diseases

(2020) Xiaonan Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MitophAging: Mitophagy in Aging and Disease

(2020) Daniela Bakula et al.   Frontiers in Cell and Developmental Biology

Autogenous Mitochondria Transplantation for Treatment of Right Heart Failure

(2020) Viktoria Weixler et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Transport of Ca2+ and Ca2+-dependent permeability transition in heart mitochondria in the early stages of Duchenne muscular dystrophy

(2020) Mikhail V. Dubinin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Novel genomic targets of valosin-containing protein in protecting pathological cardiac hypertrophy

(2020) Ning Zhou et al.   Scientific Reports

Genomic characterization reveals novel mechanisms underlying the valosin-containing protein-mediated cardiac protection against heart failure

(2020) Ning Zhou et al.   Redox Biology

Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging

(2020) Marisol Fernández-Ortiz et al.   Antioxidants

Mitochondrial dynamics: Shaping and remodeling an organelle network

(2020) Adam R. Fenton et al.   CURRENT OPINION IN CELL BIOLOGY

Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-AssociatedEndoplasmic Reticulum Membranes in vivo

(2019) Shengnan Wu et al.   CIRCULATION

Mitochondrial Biogenesis and Mitochondrial Reactive Oxygen Species (ROS): A Complex Relationship Regulated by the cAMP/PKA Signaling Pathway

(2019) Cyrielle Bouchez et al.   Cells

Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats

(2019) Chang-xiong Zhang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy

(2019) Mingming Tong et al.   CIRCULATION RESEARCH

Preconditioning the rat heart with sodium thiosulfate preserved the mitochondria in response to ischemia-reperfusion injury

(2019) Sriram Ravindran et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The valosin-containing protein protects the heart against pathological Ca2+ overload by modulating Ca2+ uptake proteins

(2019) Shaunrick Stoll et al.   TOXICOLOGICAL SCIENCES

Glucose Metabolism in Cardiac Hypertrophy and Heart Failure

(2019) Diem H. Tran et al.   Journal of the American Heart Association

Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors

(2019) Tak Shun Fung et al.   JOURNAL OF CELL SCIENCE

Therapeutic targeting of mitochondrial ROS ameliorates murine model of volume overload cardiomyopathy

(2019) Kenichi Okamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

GDF-11 prevents cardiomyocyte hypertrophy by maintaining the sarcoplasmic reticulum-mitochondria communication

(2019) Valeria Garrido-Moreno et al.   PHARMACOLOGICAL RESEARCH

Altered mitochondrial metabolism in the insulin‐resistant heart

(2019) Marina Makrecka‐Kuka et al.   Acta Physiologica

Highly selective mitochondrial probes based on fluorinated pentamethinium salts: On two-photon properties and microscopic applications

(2019) Lucie Krčová et al.   DYES AND PIGMENTS

NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α

(2018) Hao Zhou et al.   BASIC RESEARCH IN CARDIOLOGY

MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload

(2018) Rogério Faustino Ribeiro Junior et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic remodeling of substrate utilization during heart failure progression

(2018) Liang Chen et al.   HEART FAILURE REVIEWS

Metabolic remodelling in heart failure

(2018) Edoardo Bertero et al.   Nature Reviews Cardiology

MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca 2+ Stress

(2018) Neeharika Nemani et al.   Cell Reports

Combined Therapy with SS31 and Mitochondria Mitigates Myocardial Ischemia-Reperfusion Injury in Rats

(2018) Fan-Yen Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Transplantation Prolongs Cold Ischemia Time in Murine Heart Transplantation

(2018) Kamila Moskowitzova et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Here, there, and everywhere: The importance of ER membrane contact sites

(2018) Haoxi Wu et al.   SCIENCE

ARC regulates programmed necrosis and myocardial ischemia/reperfusion injury through the inhibition of mPTP opening

(2018) Tao Xu et al.   Redox Biology

SIRT-3 Modulation by Resveratrol Improves Mitochondrial Oxidative Phosphorylation in Diabetic Heart through Deacetylation of TFAM

(2018) Pankaj Bagul et al.   Cells

A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling

(2017) Leonardo Schirone et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Integrity and Function in the Progression of Early Pressure Overload–Induced Left Ventricular Remodeling

(2017) Antoine H. Chaanine et al.   Journal of the American Heart Association

Physiological Mitochondrial Fragmentation Is a Normal Cardiac Adaptation to Increased Energy Demand

(2017) Michael Coronado et al.   CIRCULATION RESEARCH

The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo

(2017) Paulo Lizano et al.   Scientific Reports

Administration of antioxidant peptide SS-31 attenuates transverse aortic constriction-induced pulmonary arterial hypertension in mice

(2016) Hung-i Lu et al.   ACTA PHARMACOLOGICA SINICA

FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress

(2016) Antoine H. Chaanine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

The impact of cardiac ischemia/reperfusion on the mitochondria–cytoskeleton interactions

(2016) Rafaela Bagur et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial remodeling: Rearranging, recycling, and reprogramming

(2016) Roberta A. Gottlieb et al.   CELL CALCIUM

Mitochondrial Metabolism in Aging Heart

(2016) Edward J. Lesnefsky et al.   CIRCULATION RESEARCH

Mitochondrial Biology and Neurological Diseases

(2016) Siddharth Arun et al.   Current Neuropharmacology

NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy

(2016) Zhongbao Yue et al.   EXPERIMENTAL CELL RESEARCH

DJ-1 protects the heart against ischemia–reperfusion injury by regulating mitochondrial fission

(2016) Yuuki Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial dynamics, mitophagy and cardiovascular disease

(2016) César Vásquez-Trincado et al.   JOURNAL OF PHYSIOLOGY-LONDON

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants

(2016)   LANCET

Cardiomyocyte Ca2+dynamics: clinical perspectives

(2016) Jan Magnus Aronsen et al.   SCANDINAVIAN CARDIOVASCULAR JOURNAL

Apoptotic transition of senescent cells accompanied with mitochondrial hyper-function

(2016) Danli Wang et al.   Oncotarget

Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis

(2016) Wei Lu et al.   PLoS One

Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection

(2016) Douglas B. Cowan et al.   PLoS One

Mitochondrial dysfunctions during progression of dystrophic cardiomyopathy

(2015) Victoria Kyrychenko et al.   CELL CALCIUM

Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type-1 diabetic hearts: a novel mechanism contributing to diabetic cardiomyopathy

(2015) Rui Ni et al.   DIABETES

Mitochondrial biogenesis and dynamics in the developing and diseased heart

(2015) Gerald W. Dorn et al.   GENES & DEVELOPMENT

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

Calcium Movement in Cardiac Mitochondria

(2014) Liron Boyman et al.   BIOPHYSICAL JOURNAL

Mechanical Unloading Promotes Myocardial Energy Recovery in Human Heart Failure

(2014) A. A. Gupte et al.   Circulation-Cardiovascular Genetics

Energy Metabolic Reprogramming in the Hypertrophied and Early Stage Failing Heart

(2014) Ling Lai et al.   Circulation-Heart Failure

Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission

(2014) Sunan Li et al.   JOURNAL OF CELL BIOLOGY

Tailor-Made Fluorescent Trilobolide To Study Its Biological Relevance

(2014) Michal Jurášek et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility

(2014) Shuai Zhang et al.   Nutrition & Metabolism

Regulation of superoxide flashes by transient and steady mitochondrial calcium elevations

(2014) ChongShu Jian et al.   Science China-Life Sciences

Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy

(2014) Ying Tang et al.   Journal of Diabetes Investigation

Mitochondrial Aging and Age-Related Dysfunction of Mitochondria

(2014) Dimitry A. Chistiakov et al.   Biomed Research International

A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery

(2014) Zhaobin Xu et al.   Jove-Journal of Visualized Experiments

Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity

(2014) Sijun Yang et al.   Redox Biology

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Rational Design of Chemical Ligands for Selective Mitochondrial Targeting

(2013) Silvie Rimpelová et al.   BIOCONJUGATE CHEMISTRY

A Role for Peroxisome Proliferator-Activated Receptor γ Coactivator-1 in the Control of Mitochondrial Dynamics During Postnatal Cardiac Growth

(2013) Ola J. Martin et al.   CIRCULATION RESEARCH

Potential Role of BNIP3 in Cardiac Remodeling, Myocardial Stiffness, and Endoplasmic Reticulum

(2013) Antoine H. Chaanine et al.   Circulation-Heart Failure

Cardiac Insulin-Resistance and Decreased Mitochondrial Energy Production Precede the Development of Systolic Heart Failure After Pressure-Overload Hypertrophy

(2013) Liyan Zhang et al.   Circulation-Heart Failure

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Correction: Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury

(2013) Hilary K. Siddall et al.   PLoS One

Mitochondrial calcium uptake

(2013) G. S. B. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?

(2012) David Gems et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates

(2012) Jian Zhao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial permeability transition pore opening induces the initial process of renal calcium crystallization

(2012) Kazuhiro Niimi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Monogenic Mitochondrial Disorders

(2012) Werner J.H. Koopman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of Serine Palmitoyl Transferase I Reduces Cardiac Ceramide Levels and Increases Glycolysis Rates following Diet-Induced Insulin Resistance

(2012) John R. Ussher et al.   PLoS One

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Transcriptional integration of mitochondrial biogenesis

(2012) Richard C. Scarpulla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics

(2011) Roberto Bravo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The complex interplay between mitochondrial dynamics and cardiac metabolism

(2011) Valentina Parra et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function

(2011) F. Billia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-induced opening of the permeability transition pore in the dystrophin-deficient heart is attenuated by acute treatment with sildenafil

(2010) Alexis Ascah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

(2010) Sumihiro Kawajiri et al.   FEBS LETTERS

Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease

(2010) Jun Ren et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission

(2010) Jason A Mears et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial Pruning by Nix and BNip3: An Essential Function for Cardiac-Expressed Death Factors

(2010) Gerald W. Dorn   Journal of Cardiovascular Translational Research

Regulation of mitochondrial dehydrogenases by calcium ions

(2009) Richard M. Denton   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Role of fatty acid uptake and fatty acid β-oxidation in mediating insulin resistance in heart and skeletal muscle

(2009) Liyan Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Diagnosis and Classification of Diabetes Mellitus

(2009)   DIABETES CARE

Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy

(2009) Luuk J. Rijzewijk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Metoprolol improves cardiac function and modulates cardiac metabolism in the streptozotocin-diabetic rat

(2008) Vijay Sharma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autophagy in aging, disease and death: the true identity of a cell death impostor

(2008) B Levine et al.   CELL DEATH AND DIFFERENTIATION

Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions

(2008) Angel Catalá   CHEMISTRY AND PHYSICS OF LIPIDS

Role of Mitochondrial Dysfunction in Insulin Resistance

(2008) Jeong-a Kim et al.   CIRCULATION RESEARCH

The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells

(2008) Shilpa Gandre-Babbe et al.   MOLECULAR BIOLOGY OF THE CELL