Cytochrome P450 inhibition potential and initial genotoxic evaluation of 14-O-[(4,6-diaminopyrimidine-2-yl)thioacetyl] mutilin

A Validated HPLC-MS/MS Assay for 14-O-[(4,6-Diaminopyrimidine-2-yl)thioacetyl] Mutilin in Biological Samples and Its Pharmacokinetic, Distribution and Excretion via Urine and Feces in Rats

(2019) Yunxing Fu et al.   MOLECULES

Genotoxicity and antioxidant activity of five Agrimonia and Filipendula species plant extracts evaluated by comet and micronucleus assays in human lymphocytes and Ames Salmonella /microsome test

(2018) Milda Pukalskienė et al.   FOOD AND CHEMICAL TOXICOLOGY

Antibacterial properties and clinical potential of pleuromutilins

(2018) Olivia Goethe et al.   NATURAL PRODUCT REPORTS

Genotoxicity assessment of biphasic calcium phosphate of modified porosity on human dental pulp cells using Ames and Comet assays

(2018) Nur Fathin Alia Che Wahab et al.   TOXICOLOGY IN VITRO

Impact of fasting followed by short-term exposure to interleukin-6 on cytochrome P450 mRNA in mice

(2018) Martin Krøyer Rasmussen et al.   TOXICOLOGY LETTERS

Design, synthesis and antibacterial evaluation of novel pleuromutilin derivatives possessing piperazine linker

(2017) Mei-Ling Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antibacterial activities of novel pleuromutilin derivatives with a substituted pyrimidine moiety

(2017) Yunpeng Yi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolopyrimidine Derivatives as Novel Inhibitors of Multidrug Resistance-Associated Protein 1 (MRP1, ABCC1)

(2016) Sven Marcel Schmitt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Pharmacological Evaluation of Novel Pleuromutilin Derivatives with Substituted Benzimidazole Moieties

(2016) Xin Ai et al.   MOLECULES

Inhibition of cytochrome P450 3A by acetoxylated analogues of resveratrol in in vitro and in silico models

(2016) Loai Basheer et al.   Scientific Reports

HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2)

(2015) Sebastian C. Köhler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Activities of Novel Pleuromutilin Derivatives with a Substituted Thiadiazole Moiety as Potent Drug-Resistant Bacteria Inhibitors

(2014) Ruofeng Shang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure–Activity Relationship Studies of Novel Thioether Pleuromutilin Derivatives as Potent Antibacterial Agents

(2014) Chenyu Ling et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genotoxic evaluation of aspirin eugenol ester using the Ames test and the mouse bone marrow micronucleus assay

(2013) Jianyong Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Are pleuromutilin antibiotics finally fit for human use?

(2011) Rodger Novak   Annals of the New York Academy of Sciences

Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions

(2011) Kye Sook Lee et al.   JOURNAL OF APPLIED TOXICOLOGY

Retapamulin: A novel topical antibiotic

(2010) H Nagabushan   Indian Journal of Dermatology Venereology & Leprology

Prevalence of Exposure to Potential CYP450 Pharmacokinetic Drug-Drug Interactions among Patients with Chronic Low Back Pain Taking Opioids

(2010) Joseph V. Pergolizzi Jr. et al.   Pain Practice

Microbiological profile of a new topical antibacterial: retapamulin ointment 1%

(2009) Nicole E Scangarella-Oman et al.   Expert Review of Anti-Infective Therapy

Genotoxicity evaluation of locally produced dental porcelain – An in vitro study using the Ames and Comet assays

(2009) Mohammed Noushad et al.   TOXICOLOGY IN VITRO

Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues

(2008) Petr Pavek et al.   CURRENT DRUG METABOLISM